Human gastric pacesetter potential

1977 ◽  
Vol 133 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Ronald A. Hinder ◽  
Keith A. Kelly
Keyword(s):  
Pacesetter Potential

Role of the Gastric Pacesetter Potential Defined by Electrical Pacing

1972 ◽  
Vol 50 (10) ◽  
pp. 1017-1019 ◽  
Author(s):  
Keith A. Kelly ◽  
Richard C. La Force
Keyword(s):  
Contractile Activity ◽  
Electrical Pacing ◽  
Electrical Stimuli ◽  
Gastric Contractions ◽  
Pacesetter Potential

This experiment substantiates the hypothesis that the gastric pacesetter potential sets the pace of gastric contractions. By pacing the gastric pacesetter potential with electrical stimuli during periods of spontaneous and pentagastrin-induced contractile activity, we also paced gastric contractions.

scholarly journals Pathways of Propagation of the Canine Gastric Pacesetter Potential

1972 ◽  
Vol 63 (2) ◽  
pp. 288-296 ◽  
Author(s):  
Balwinder S. Bedi ◽  
Keith A. Kelly ◽  
Keith E. Holley
Keyword(s):  
Pacesetter Potential

Pacesetter potential conduction velocity predicts roux-en-y functional activity

1994 ◽  
Vol 107 (4) ◽  
pp. 1239
Author(s):  
S. Liao ◽  
JDZ Chen ◽  
X. Yi ◽  
B. Schirmer
Keyword(s):  
Conduction Velocity ◽  
Functional Activity ◽  
Pacesetter Potential

Electrical control of canine jejunal propulsion

1981 ◽  
Vol 240 (5) ◽  
pp. G355-G360 ◽  
Author(s):  
M. G. Sarr ◽  
K. A. Kelly ◽  
H. E. Gladen
Keyword(s):  
Action Potentials ◽  
Intestinal Content ◽  
Jejunal Loop ◽  
Electrical Control ◽  
Pacesetter Potentials ◽  
Direction Of Movement ◽  
Pacesetter Potential

We wondered whether the direction of propagation of intestinal pacesetter potentials determines the direction of movement of intestinal content. In six dogs, electrodes for pacing were implanted near each end of an 80-cm isolated jejunal loop, and a cannula was positioned at the middle of the loop for intraluminal insertion of solids and/or liquids. After recovery and during fasting, 50 nylon spheres (2 mm diam) always emptied from the distal stoma regardless of the direction of pacing. In contrast, 150 mM NaCl, given alone at 2.8 ml/min or with spheres, emptied from the distal stoma during forward pacing and from the proximal stoma during backward pacing. Spheres given with the liquid emptied from the distal stoma during forward pacing, but during backward pacing, the site of emptying varied among dogs. Neither pacing nor spheres altered jejunal interdigestive myoelectric cycles, but the perfusate abolished the cycles and resulted in a noncyclic pattern of jejunal action potentials. We concluded that the direction of pacesetter potential propagation determined the direction of liquid transit. Direction of solid transit depended, in part, on other mechanisms.

Frequency of gastric pacesetter potential depends on volume and site of distension

1996 ◽  
Vol 270 (3) ◽  
pp. G470-G475 ◽  
Author(s):  
H. C. Lin ◽  
X. T. Zhao ◽  
B. Chung ◽  
Y. G. GU ◽  
J. D. Elashoff
Keyword(s):  
Small Intestine ◽  
Gastric Emptying ◽  
Small Bowel ◽  
Analysis Of Variance ◽  
Pacesetter Potential

Little is known about the response of the frequency of gastric pacesetter potential (PP) to luminal distension. When volume distension occurs as a result of a meal, gastric emptying may play an important role, since the site of distension shifts as the meal is displaced from the stomach to the small bowel. In this study, using does equipped with duodenal fistulas and serosal electrodes on the antrum, we compared the frequency of gastric PP during the course of gastric emptying while isolating the volume distension to either the stomach or the small bowel. We found that 1) the frequency of gastric PP decreased linearly with greater initial meal volume when volume distension was isolated to either the stomach -P<0.05, analysis of variance (ANOVA)- or small bowel (P<0.01, ANOVA), and 2) the frequency of gastric PP decreased linearly with increased volume remaining in the stomach or increased volume entering the small intestine. We conclude that the frequency of gastric PP depends on the volume and site of distension.

A concept of motor control by the pacesetter potential in the stomach and small bowel

1971 ◽  
Vol 16 (7) ◽  
pp. 599-601 ◽  
Author(s):  
Charles F. Code ◽  
Joseph H. Szurszewski ◽  
Keith A. Kelly
Keyword(s):  
Motor Control ◽  
Small Bowel ◽  
Pacesetter Potential

Regulation of canine jejunal transit

1990 ◽  
Vol 259 (6) ◽  
pp. G928-G933
Author(s):  
N. J. Soper ◽  
K. L. Geisler ◽  
M. G. Sarr ◽  
K. A. Kelly ◽  
A. R. Zinsmeister
Keyword(s):  
Mean Transit Time ◽  
Intraluminal Pressure ◽  
Reversed Flow ◽  
Forward Flow ◽  
Pacesetter Potentials ◽  
Direction Of Movement ◽  
Loop Volume ◽  
The Mean ◽  
Pacesetter Potential ◽  
Recording Electrodes

The aim of this study was to determine what factors influence the direction of movement of canine jejunal chyme. In four dogs, pacing electrodes were implanted near each end of a 50-cm jejunal Vella loop, while recording electrodes and intraluminal pressure catheters were spaced along the loop. After recovery, the loop was perfused from either the proximal stoma (forward flow) or the distal stoma (reversed flow), and effluent was collected from the nonperfused stoma. The pacesetter potentials were paced electrically in a forward (aborad) or a reverse (orad) direction. During control conditions (forward flow-forward pacing), the mean transit time of liquids was 2.6 +/- 0.1 min (mean +/- SE) and the static volume of the loop was 8.8 +/- 0.3 ml. Reversing both direction of flow and direction of pacesetter potential propagation slowed transit (4.4 +/- 0.4 min; P less than 0.05) and increased loop volume (16.0 +/- 1.0 ml; P less than 0.01). Reversing flow with forward pacing resulted in even slower transit (7.5 +/- 1.2 min; P less than 0.05), maintained a large volume (33 +/- 10 ml), and increased basal pressure in the loop from -1.2 +/- 1.7 (control) to 2.3 +/- 1.6 mmHg (P less than 0.05). These observations suggest that the direction of propagation of jejunal pacesetter potentials influences the direction of movement of jejunal chyme but that other factors have a role as well.

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