Conformational comparison of human pituitary growth hormone and human chorionic somatomammotropin (human placental lactogen) by second-order absorption spectroscopy

1984 ◽  
Vol 233 (1) ◽  
pp. 219-227 ◽  
Author(s):  
Thomas A. Bewley ◽  
Choh Hao Li
Keyword(s):  
Growth Hormone ◽  
Absorption Spectroscopy ◽  
Second Order ◽  
Placental Lactogen ◽  
Human Placental Lactogen ◽  
Human Pituitary ◽  
Pituitary Growth Hormone ◽  
Chorionic Somatomammotropin

Regulation of maternal IGF-I by placental GH in normal and abnormal human pregnancies

1993 ◽  
Vol 265 (4) ◽  
pp. E572-E577 ◽  
Author(s):  
A. Caufriez ◽  
F. Frankenne ◽  
G. Hennen ◽  
G. Copinschi
Keyword(s):  
Growth Hormone ◽  
Normal Pregnancy ◽  
Placental Lactogen ◽  
Human Placental Lactogen ◽  
Blood Samples ◽  
Gh Secretion ◽  
Factor I ◽  
Gestational Period ◽  
Pituitary Growth Hormone ◽  
Igf I

Throughout gestation, maternal insulin-like growth factor I (IGF-I) increases progressively despite suppressed pituitary growth hormone (GH) secretion. We have previously shown that in normal pregnancy, a specific placental GH variant, rather than human placental lactogen (hPL), substitutes for pituitary GH in the regulation of maternal IGF-I. We studied the maternal IGF-I secretion in a cohort of 286 normal and abnormal pregnancies (617 blood samples). Regardless of pathology and gestational age, IGF-I values correlated with corresponding placental GH but not with hPL values. Similar correlations were evidenced for each 2-wk gestational period between 32 and 39 wk. In pathological pregnancies, when only those hormonal results that are obtained before any treatment are considered and diabetes is excluded, IGF-I levels were closely related to corresponding placental GH, but not to hPL. In women with a fetoplacental unit disorder, low placental GH levels resulted in low IGF-I and in a secondary pituitary GH increase, whereas in patients without detectable impairment of the fetoplacental unit normal placental GH corresponded to normal IGF-I. These results suggest that in pathological as well as in normal pregnancy, placental GH, and not hPL, substitutes for pituitary GH to regulate the maternal IGF-I secretion.

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