In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

Styliani H. Vincent; Bindhu V. Karanam; Susan K. Painter; Shuet-Hing L. Chiu

doi:10.1016/0003-9861(92)90711-5

In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

Archives of Biochemistry and Biophysics ◽

10.1016/0003-9861(92)90711-5 ◽

1992 ◽

Vol 294 (2) ◽

pp. 454-460 ◽

Cited By ~ 81

Author(s):

Styliani H. Vincent ◽

Bindhu V. Karanam ◽

Susan K. Painter ◽

Shuet-Hing L. Chiu

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Major Metabolite ◽

In Vitro Metabolism ◽

Cytochrome P450 3A ◽

Fk 506

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Study of in vitro metabolism of m-nisoldipine in human liver microsomes and recombinant cytochrome P450 enzymes by liquid chromatography–mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2014.03.030 ◽

2014 ◽

Vol 97 ◽

pp. 65-71 ◽

Cited By ~ 20

Author(s):

Lin Yuan ◽

Peipei Jia ◽

Yupeng Sun ◽

Chengcheng Zhao ◽

Xuran Zhi ◽

...

Keyword(s):

Mass Spectrometry ◽

Cytochrome P450 ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Liquid Chromatography Mass Spectrometry ◽

Cytochrome P450 Enzymes

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In Vitro metabolism of Jaceosidin and characterization of cytochrome P450 and UDP-glucuronosyltransferase enzymes in human liver microsomes

Archives of Pharmacal Research ◽

10.1007/s12272-010-1214-1 ◽

2010 ◽

Vol 33 (12) ◽

pp. 1985-1996 ◽

Cited By ~ 10

Author(s):

Won Young Song ◽

Hye Young Ji ◽

Nam-In Baek ◽

Tae-Sook Jeong ◽

Hye Suk Lee

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Udp Glucuronosyltransferase

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In Vitro Metabolism of a New Neuroprotective Agent, KR-31543 in the Human Liver Microsomes: Identification of Human Cytochrome P450

Archives of Pharmacal Research ◽

10.1007/bf02980112 ◽

2004 ◽

Vol 27 (2) ◽

pp. 239-245 ◽

Cited By ~ 4

Author(s):

Hye Young Ji ◽

Seung-Seok Lee ◽

Sung-Eun Yoo ◽

Hosoon Kim ◽

Dong Ha Lee ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Neuroprotective Agent ◽

Human Cytochrome

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In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes

Xenobiotica ◽

10.1080/00498254.2016.1203041 ◽

2016 ◽

Vol 47 (6) ◽

pp. 461-469 ◽

Cited By ~ 1

Author(s):

Matthew Y. Bendikov ◽

John O. Miners ◽

Bradley S. Simpson ◽

David J. Elliot ◽

Susan J. Semple ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Hydrolysis Product ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Udp Glucuronosyltransferase ◽

Clerodane Diterpenoid ◽

Anti Inflammatory

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ChemInform Abstract: Structural Investigations of 13-O-Demethyl-FK 506 and Its Isomers Generated by in vitro Metabolism of FK 506 Using Human-Liver Microsomes.

ChemInform ◽

10.1002/chin.199352289 ◽

2010 ◽

Vol 24 (52) ◽

pp. no-no

Author(s):

W. SCHUELER ◽

U. CHRISTIANS ◽

P. SCHMIEDER ◽

H.-M. SCHIEBEL ◽

I. HOLZE ◽

...

Keyword(s):

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Fk 506 ◽

Structural Investigations

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In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms

Chemico-Biological Interactions ◽

10.1016/s0009-2797(99)00107-6 ◽

1999 ◽

Vol 122 (1) ◽

pp. 27-39 ◽

Cited By ~ 38

Author(s):

Scott Coleman ◽

Siming Liu ◽

Russell Linderman ◽

Ernest Hodgson ◽

Randy L Rose

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Human Cytochrome ◽

Cytochrome P450 Isoforms

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P160 - In vitro metabolism of endosulfan sulfate in human liver microsomes, S9 fractions and hepatocytes

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2020.04.161 ◽

2020 ◽

Vol 35 (1) ◽

pp. S71-S72

Author(s):

Hwa-Kyung Lee ◽

Jeong-Han Kim ◽

Tae Yeon Kong ◽

Won-Gu Choi ◽

Ju-Hyun Kim ◽

...

Keyword(s):

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism ◽

Endosulfan Sulfate

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Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes

Xenobiotica ◽

10.1080/00498250110065595 ◽

2001 ◽

Vol 31 (10) ◽

pp. 713-723 ◽

Cited By ~ 31

Author(s):

M. Miyazawa ◽

M. Shindo ◽

T. Shimada

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Liver Microsomes ◽

Cyclic Ether ◽

Human Liver Microsomes ◽

Cytochrome P450 3A

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CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes

Acta Pharmacologica Sinica ◽

10.1111/j.1745-7254.2007.00484.x ◽

2007 ◽

Vol 28 (1) ◽

pp. 118-124 ◽

Cited By ~ 14

Author(s):

Xiao-ping Zhao ◽

Jiao Zhong ◽

Xiao-quan Liu ◽

Guang-ji Wang

Keyword(s):

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

In Vitro Metabolism

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Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes

Drug Metabolism and Disposition ◽

10.1124/dmd.121.000497 ◽

2021 ◽

pp. DMD-AR-2021-000497

Author(s):

Elaine Tseng ◽

Heather Eng ◽

Jian Lin ◽

Matthew A. Cerny ◽

David A. Tess ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Time Dependent ◽

Cytochrome P450 3A

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