The role of messenger RNA in tyrosine aminotransferase superinduction: Effects of camptothecin on hepatoma cells in culture

1974 ◽  
Vol 56 (3) ◽  
pp. 815-821 ◽  
Author(s):  
Donald E. Bushnell ◽  
Joyce E. Becker ◽  
Van R. Potter
Keyword(s):  
Messenger Rna ◽  
Tyrosine Aminotransferase ◽  
Hepatoma Cells ◽  
Cells In Culture

Development of tyrosine aminotransferase in perinatal rat liver: Changes in functional messenger RNA and the role of inducing hormones

1983 ◽  
Vol 21 (1) ◽  
pp. 47-61 ◽  
Author(s):  
Stephanie T. Perry ◽  
Robin Rothrock ◽  
Kenneth R. Isham ◽  
Kai-Lin Lee ◽  
Francis T. Kenney
Keyword(s):  
Rat Liver ◽  
Messenger Rna ◽  
Tyrosine Aminotransferase ◽  
Liver Changes

Control of Degradation and Synthesis of Induced Tyrosine Aminotransferase studied in Hepatoma Cells in Culture

Nature ◽  
1969 ◽  
Vol 224 (5221) ◽  
pp. 806-808 ◽  
Author(s):  
FERDINANDO AURICCHIO ◽  
DAVID MARTIN ◽  
GORDON TOMKINS
Keyword(s):  
Tyrosine Aminotransferase ◽  
Hepatoma Cells ◽  
Cells In Culture

Role of pro-opiomelanocortin-derived peptides in the regulation of steroid production by human fetal adrenal cells in culture

1983 ◽  
Vol 97 (3) ◽  
pp. 357-367 ◽  
Author(s):  
Andrew Baird ◽  
K. W. Kan ◽  
Samuel Solomon
Keyword(s):  
Peptide Hormones ◽  
The Other ◽  
Dehydroepiandrosterone Sulphate ◽  
Steroid Production ◽  
Adrenal Cells ◽  
The Third ◽  
Cells In Culture

Synthetic (1–39)ACTH, (1–24)ACTH, (18–39)ACTH, α-MSH, met-enkephalin and α-, βand γ-endorphin were tested for their ability to stimulate steroidogenesis by human fetal adrenal cells in culture. Adrenal cells were incubated with peptide hormones for two periods of 24 h. On the third day of the experiment the cells were incubated with progesterone (4 μg/2 ml) for 8 h. At the doses tested only (1–39)ACTH, (1–24)ACTH and α-MSH stimulated steroidogenesis. None of the other peptides had any corticotrophic effect on the formation of cortisol, corticosterone or dehydroepiandrosterone sulphate (DHAS). At the highest doses tested, α-MSH (100 μg/2 ml) had a corticotrophic effect that was not different from that obtained with 20 ng (1–39)ACTH or (1–24)ACTH. At the lower doses (0·2–2 μg/2 ml), α-MSH stimulated the formation of DHAS (P<0·01) without stimulating the formation of cortisol.

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