Effects of ventro-medial mesencephalic tegmentum (VMT) stimulation on the spontaneous activity of nucleus accumbens neurones: Influence of the dopamine system

1986 ◽  
Vol 363 (2) ◽  
pp. 290-298 ◽  
Author(s):  
C. Le Douarin ◽  
J. Penit ◽  
J. Glowinski ◽  
A.M. Thierry
Keyword(s):  
Nucleus Accumbens ◽  
Spontaneous Activity ◽  
Dopamine System

scholarly journals Interruption of Continuous Opioid Exposure Exacerbates Drug-Evoked Adaptations in the Mesolimbic Dopamine System

2019 ◽  
Author(s):  
Emilia M. Lefevre ◽  
Marc T. Pisansky ◽  
Carlee Toddes ◽  
Federico Baruffaldi ◽  
Marco Pravetoni ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nucleus Accumbens ◽  
Dorsal Striatum ◽  
Locomotor Sensitization ◽  
Continuous Exposure ◽  
Mesolimbic Dopamine ◽  
Dopamine System ◽  
Mesolimbic Dopamine System ◽  
Opioid Administration ◽  
Dopamine Signaling

ABSTRACTDrug-evoked adaptations in the mesolimbic dopamine system are postulated to drive opioid abuse and addiction. These adaptations vary in magnitude and direction following different patterns of opioid exposure, but few studies have systematically manipulated the pattern of opioid administration while measuring neurobiological and behavioral impact. We exposed male and female mice to morphine for one week, with administration patterns that were either intermittent (daily injections) or continuous (osmotic minipump infusion). We then interrupted continuous morphine exposure with either naloxone-precipitated or spontaneous withdrawal. Continuous morphine exposure caused tolerance to the psychomotor-activating effects of morphine, whereas both intermittent and interrupted morphine exposure caused long-lasting psychomotor sensitization. Given links between locomotor sensitization and mesolimbic dopamine signaling, we used fiber photometry and a genetically encoded dopamine sensor to conduct longitudinal measurements of dopamine dynamics in the nucleus accumbens. Locomotor sensitization caused by interrupted morphine exposure was accompanied by enhanced dopamine signaling in the nucleus accumbens. To further assess downstream consequences on striatal gene expression, we used next-generation RNA sequencing to perform genome-wide transcriptional profiling in the nucleus accumbens and dorsal striatum. The interruption of continuous morphine exposure exacerbated drug-evoked transcriptional changes in both nucleus accumbens and dorsal striatum, dramatically increasing differential gene expression and engaging unique signaling pathways. Our study indicates that opioid-evoked adaptations in brain function and behavior are critically dependent on the pattern of drug administration, and exacerbated by interruption of continuous exposure. Maintaining continuity of chronic opioid administration may therefore represent a strategy to minimize iatrogenic effects on brain reward circuits.

scholarly journals The mesolimbic dopamine signatures of relapse to alcohol-seeking

2020 ◽  
Author(s):  
Yu Liu ◽  
Philip Jean-Richard-dit-Bressel ◽  
Joanna Oi-Yue Yau ◽  
Alexandra Willing ◽  
Asheeta A. Prasad ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Activity Patterns ◽  
Mesolimbic Dopamine ◽  
Self Administration ◽  
Dopamine System ◽  
Mesolimbic Dopamine System ◽  
Ventral Tegmental ◽  
Alcohol Seeking

AbstractThe mesolimbic dopamine system comprises distinct compartments supporting different functions in learning and motivation. Less well understood is how complex addiction-related behaviors emerge from activity patterns across these compartments. Here we show how different forms of relapse to alcohol-seeking are assembled from activity across the ventral tegmental area and the nucleus accumbens. Using gCaMP and dLight fibre photometry, we show that self-administration and two forms of relapse (renewal/context-induced reinstatement and reacquisition) are associated with recruitment across the mesolimbic dopamine system. Using a variety of interventions, we show that this activity is causal to both forms of relapse. Finally, we use dissimilarity matrices to identify mesolimbic dopamine signatures of self-administration, extinction, and relapse. We show that signatures of relapse can be identified from heterogeneous activity profiles across the mesolimbic dopamine system and that these signatures differ for different forms of relapse.

Effect of neurotensin on regional cerebral glucose utilization in cold water-restrained rats

1990 ◽  
Vol 258 (4) ◽  
pp. G591-G595
Author(s):  
L. P. Xing ◽  
J. C. King ◽  
R. M. Bryan ◽  
G. L. Kauffman
Keyword(s):  
Nucleus Accumbens ◽  
Glucose Utilization ◽  
Cold Water ◽  
Mucosal Injury ◽  
Ulcer Formation ◽  
Neuronal Function ◽  
Dopamine System ◽  
Mesolimbic Dopamine System ◽  
Or Groups ◽  
Nuclear Group

Neurotensin (NT), given intracerebroventricularly (icv), attenuates cold water restraint (CWR)-induced gastric mucosal injury; however, it is not clear which brain nuclear group or groups are involved. These studies tested the hypothesis that neuronal function, as measured by regional cerebral metabolic rate for glucose (rCMRGlc), is altered by icv NT with or without CWR. CWR resulted in a reduced global glucose utilization of 72 and 65% in control and NT-treated rats, respectively. NT, given icv, protected against ulcer formation induced by CWR. In those rats given NT icv, rCMRGlc was elevated significantly in amygdala, nucleus accumbens, substantia nigra, tuberculum olfactrium, hypothalamus, and cerebellum compared with CWR rats without NT pretreatment. This rCMRGlc increase was observed in both unstressed and stressed rats given NT icv in the nucleus accumbens and amygdala. These observations suggest that the nucleus accumbens and amygdala, both components of the mesolimbic dopamine system, are involved in the central action of NT on the gastric mucosa.

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