Inhibiting synthesis of the putative retrograde messenger nitric oxide results in amnesia in a passive avoidance task in the chick

1993 ◽  
Vol 619 (1-2) ◽  
pp. 189-194 ◽  
Author(s):  
Christian Ho¨lscher ◽  
Steven P.R. Rose
Keyword(s):  
Nitric Oxide ◽  
Passive Avoidance ◽  
Passive Avoidance Task ◽  
Avoidance Task ◽  
Retrograde Messenger

scholarly journals 7-Nitro indazole, a neuron-specific nitric oxide synthase inhibitor, produces amnesia in the chick.

1994 ◽  
Vol 1 (4) ◽  
pp. 213-216
Author(s):  
C Hölscher
Keyword(s):  
Nitric Oxide ◽  
Synaptic Plasticity ◽  
Nitric Oxide Synthase ◽  
Blood Vessel ◽  
Passive Avoidance ◽  
Avoidance Task ◽  
Nitric Oxide Synthase Inhibitor ◽  
Nos Inhibitors ◽  
Synthase Inhibitor ◽  
Oxide Synthase

7-Nitro indazole (7-NI), which is selective for the neuronal isoform of nitric oxide synthase (NOS), was tested in a passive avoidance task in the chick. Injection of 50 mg/kg i.p. pretraining had amnesic effects for the task when tested 30 min, 2 or 24 hr after training. Injections post-training had no effect. Because 7-NI does not inhibit the endothelial isoform of NOS, it does not affect blood vessel relaxation, as nonspecific inhibitors do. This effect on blood vessels could explain the amnestic effects produced by nonspecific NOS inhibitors. The results support the theory that NO is a neuronal transmitter that is important in processes of synaptic plasticity and learning.

Effects of Large and Small Bilateral Hippocampal Lesions on Two Types of Passive-Avoidance Responses

1965 ◽  
Vol 16 (3_suppl) ◽  
pp. 1277-1290 ◽  
Author(s):  
Daniel R. Snyder ◽  
Robert L. Isaacson
Keyword(s):  
Passive Avoidance ◽  
Food Reward ◽  
Dorsal Hippocampus ◽  
Passive Avoidance Task ◽  
The Other ◽  
Hippocampal Damage ◽  
Avoidance Task ◽  
Small Compartment ◽  
Hippocampal Lesions ◽  
Avoidance Responses

Ten rats with large bilateral hippocampectomies, 10 rats with smaller amounts of damage of the dorsal hippocampus, 10 rats with destruction of postero-lateral neocortex, and 15 normal animals were trained in two types of passive-avoidance situations. One passive-avoidance task required inhibition of drinking while thirsty, the other required an animal to refrain from entering a small compartment after i: had been trained to enter, while hungry, for a food reward. Animals with the largest amounts of hippocampal destruction were impaired in both types of problems. Animals with smaller degrees of hippocampal damage were not different from normal animals in their ability to inhibit licking but were impaired in the other task. Animals with neocortical destruction showed impairment only in the licking situation.

Sign in / Sign up

Export Citation Format

Share Document