Daily variations in melatonin receptor density of rat pars tuberalis and suprachiasmatic nuclei are distinctly regulated

1994 ◽  
Vol 641 (1) ◽  
pp. 92-98 ◽  
Author(s):  
François Gauer ◽  
Mireille Masson-Pevet ◽  
Jörg Stehle ◽  
Paul Pevet
Keyword(s):  
Pars Tuberalis ◽  
Receptor Density ◽  
Suprachiasmatic Nuclei ◽  
Melatonin Receptor ◽  
Daily Variations

Effect of a light pulse on melatonin receptor density and mRNA expression in Siberian hamster suprachiasmatic nuclei

1997 ◽  
Vol 233 (1) ◽  
pp. 49-52 ◽  
Author(s):  
François Gauer ◽  
Carole Schuster ◽  
Paul Pévet ◽  
Mireille Masson-Pévet
Keyword(s):  
Mrna Expression ◽  
Light Pulse ◽  
Receptor Density ◽  
Suprachiasmatic Nuclei ◽  
Melatonin Receptor ◽  
Siberian Hamster

Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling

2005 ◽  
Vol 22 (11) ◽  
pp. 2845-2854 ◽  
Author(s):  
Antje Jilg ◽  
Juliane Moek ◽  
David R. Weaver ◽  
Horst-Werner Korf ◽  
Jörg H. Stehle ◽  
...  
Keyword(s):  
Pars Tuberalis ◽  
Melatonin Receptor ◽  
Receptor Signalling ◽  
Clock Proteins ◽  
Mt1 Melatonin Receptor

Interstrain differences in activity pattern, pineal function, and SCN melatonin receptor density of rats

1999 ◽  
Vol 276 (4) ◽  
pp. R1078-R1086 ◽  
Author(s):  
Gabriela Klante ◽  
Karin Secci ◽  
Mireille Masson-Pévet ◽  
Paul Pévet ◽  
Berthe Vivien-Roels ◽  
...  
Keyword(s):  
Wheel Running ◽  
Activity Patterns ◽  
Temporal Organization ◽  
Receptor Density ◽  
Melatonin Receptor ◽  
Time Pattern ◽  
Melatonin Synthesis ◽  
Running Activity ◽  
Wheel Running Activity ◽  
Inbred Rat

We investigated the possibility that strain-dependent differences in the diurnal pattern of wheel running activity rhythms are also reflected in the melatonin profiles. The inbred rat strains ACI/Ztm, BH/Ztm, and LEW/Ztm. LEW were examined for diurnal [12:12-h light-dark (LD)] wheel running activity, urinary 6-sulphatoxymelatonin (aMT6s) excretion, melatonin concentrations of plasma and pineal glands, and melatonin receptor density in the suprachiasmatic nuclei (SCN). ACI rats displayed unimodal activity patterns with a high level of activity, whereas BH and LEW rats showed multimodal activity patterns with ultradian components and reduced activity levels. In contrast, the individual daily profiles of aMT6s excretion and mean melatonin synthesis followed a unimodal time pattern in all three strains, suggesting that different output pathways of the SCN are responsible for the temporal organization of locomotor activity and pineal melatonin synthesis. In addition, melatonin synthesis at night and SCN melatonin receptor density at day were significantly higher in BH and LEW rats than in ACI rats. These results support the hypothesis of a long-term stimulating effect of melatonin on its own receptor density in the SCN.

scholarly journals What is the role of melatonin within the anterior pituitary?

2001 ◽  
Vol 170 (3) ◽  
pp. 493-501 ◽  
Author(s):  
DG Hazlerigg
Keyword(s):  
Anterior Pituitary ◽  
Cellular Level ◽  
Prolactin Secretion ◽  
Receptor Expression ◽  
Melatonin Receptors ◽  
Seasonal Effects ◽  
Pars Tuberalis ◽  
Melatonin Receptor ◽  
Functional Studies

The pineal hormone, melatonin, is uniquely defined by its role as hormonal time, but the processes whereby cells extract temporal information from the melatonin signal are not understood. Melatonin receptors are expressed in the pars tuberalis (PT) and, during fetal and perinatal life, in the pars distalis (PD). Functional studies suggest that the PT mediates the seasonal effects of melatonin on prolactin secretion, whilst the PD may be involved in photoperiodic programming of the developing gonadotrophic axis. To understand these effects at the cellular level we need to know the phenotype of melatonin-responsive cells. This review summarises current understanding in this area, and highlights present shortcomings. A case is presented for exploring the hypothesis that there is a functional association between melatonin receptor expression and cell differentiation in the anterior pituitary.

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