Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling

2005 ◽  
Vol 22 (11) ◽  
pp. 2845-2854 ◽  
Author(s):  
Antje Jilg ◽  
Juliane Moek ◽  
David R. Weaver ◽  
Horst-Werner Korf ◽  
Jörg H. Stehle ◽  
...  
Keyword(s):  
Pars Tuberalis ◽  
Melatonin Receptor ◽  
Receptor Signalling ◽  
Clock Proteins ◽  
Mt1 Melatonin Receptor

scholarly journals The mt1 Melatonin Receptor and RORβ Receptor Are Co-localized in Specific TSH-immunoreactive Cells in the Pars Tuberalis of the Rat Pituitary

2002 ◽  
Vol 50 (12) ◽  
pp. 1647-1657 ◽  
Author(s):  
Paul Klosen ◽  
Christele Bienvenu ◽  
Olivier Demarteau ◽  
Hugues Dardente ◽  
Hilda Guerrero ◽  
...  
Keyword(s):  
Cell Types ◽  
Orphan Receptor ◽  
Seasonal Effects ◽  
Pars Tuberalis ◽  
Melatonin Receptor ◽  
Functional Studies ◽  
Rat Pituitary ◽  
Mt1 Melatonin Receptor

The pars tuberalis (PT) of the pituitary represents an important target site for the time-pacing pineal hormone melatonin because it expresses a large number of mt1 receptors. Functional studies suggest that the PT mediates the seasonal effects of melatonin on prolactin (PRL) secretion. The aim of this study was the characterization of the pheno-type of melatonin-responsive cells. Furthermore, we determined whether RORβ, a retinoid orphan receptor present in the PT, was co-expressed in the same cells. We combined nonradioactive in situ hybridization (ISH) with hapten-labeled riboprobes for detection of the receptors and immunocytochemistry (ICC) for detection of αGSU (α-glycoprotein subunit), βTSH, βFSH, βLH, GH, PRL, and ACTH. Expression of mt1 mRNA was found in small round cells, co-localized with αGSU and βTSH. However, not all βTSH-containing cells expressed mt1 mRNA. The distribution of mt1- and RORβ-positive cells appeared to overlap, although more cells were labeled for RORβ than for mt1. Gonadotrophs, as well as other pars distalis cell types, were never labeled for mt1 melatonin receptor. Therefore, this study identifies the “specific” cells of the PT as the mt1 melatonin receptor-expressing cells.

scholarly journals Structural basis of ligand recognition at the human MT1 melatonin receptor

Nature ◽  
2019 ◽  
Vol 569 (7755) ◽  
pp. 284-288 ◽  
Author(s):  
Benjamin Stauch ◽  
Linda C. Johansson ◽  
John D. McCorvy ◽  
Nilkanth Patel ◽  
Gye Won Han ◽  
...  
Keyword(s):  
Structural Basis ◽  
Ligand Recognition ◽  
Melatonin Receptor ◽  
Mt1 Melatonin Receptor

scholarly journals What is the role of melatonin within the anterior pituitary?

2001 ◽  
Vol 170 (3) ◽  
pp. 493-501 ◽  
Author(s):  
DG Hazlerigg
Keyword(s):  
Anterior Pituitary ◽  
Cellular Level ◽  
Prolactin Secretion ◽  
Receptor Expression ◽  
Melatonin Receptors ◽  
Seasonal Effects ◽  
Pars Tuberalis ◽  
Melatonin Receptor ◽  
Functional Studies

The pineal hormone, melatonin, is uniquely defined by its role as hormonal time, but the processes whereby cells extract temporal information from the melatonin signal are not understood. Melatonin receptors are expressed in the pars tuberalis (PT) and, during fetal and perinatal life, in the pars distalis (PD). Functional studies suggest that the PT mediates the seasonal effects of melatonin on prolactin secretion, whilst the PD may be involved in photoperiodic programming of the developing gonadotrophic axis. To understand these effects at the cellular level we need to know the phenotype of melatonin-responsive cells. This review summarises current understanding in this area, and highlights present shortcomings. A case is presented for exploring the hypothesis that there is a functional association between melatonin receptor expression and cell differentiation in the anterior pituitary.

scholarly journals Expression of the MT1 Melatonin Receptor in Ovarian Cancer Cells

2014 ◽  
Vol 15 (12) ◽  
pp. 23074-23089 ◽  
Author(s):  
Karolina Jablonska ◽  
Bartosz Pula ◽  
Agata Zemla ◽  
Christopher Kobierzycki ◽  
Witold Kedzia ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Melatonin Receptor ◽  
Mt1 Melatonin Receptor
Sign in / Sign up

Export Citation Format

Share Document