Analysis of a mouse monoclonal antibody detecting the H type 1 blood group determinant

1988 ◽  
Vol 178 (1) ◽  
pp. 333-336 ◽  
Author(s):  
Sydney Welt ◽  
Beatrice W.T. Yin ◽  
Koichi Furukawa ◽  
Karl-Anders Karlsson ◽  
Lloyd J. Old ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Blood Group ◽  
Mouse Monoclonal Antibody

Mouse monoclonal antibody F-3 recognizes the difucosyl type-2 blood group structure

1983 ◽  
Vol 17 (5) ◽  
pp. 537-541 ◽  
Author(s):  
Kenneth O. Lloyd ◽  
G�ran Larson ◽  
Nicklas Str�mberg ◽  
Jan Thurin ◽  
Karl-Anders Karlsson
Keyword(s):  
Monoclonal Antibody ◽  
Blood Group ◽  
Group Structure ◽  
Mouse Monoclonal Antibody

scholarly journals The monoclonal antibody anti-SSEA-1 discriminates between fucosylated type 1 and type 2 blood group chains

FEBS Letters ◽  
1981 ◽  
Vol 131 (2) ◽  
pp. 279-282 ◽  
Author(s):  
Elizabeth F. Hounsell ◽  
H.C. Gooi ◽  
Ten Feizi
Keyword(s):  
Monoclonal Antibody ◽  
Blood Group

A marker of human foetal endoderm defined by a monoclonal antibody involves type 1 blood group chains

1983 ◽  
Vol 20 (6) ◽  
pp. 607-613 ◽  
Author(s):  
H.C. Gooi ◽  
L.K. Williams ◽  
K. Uemura ◽  
E.F. Hounsell ◽  
R.A.J. McIlhinney ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Blood Group

scholarly journals A potent neutralizing mouse monoclonal antibody specific to dengue virus type 1 Mochizuki strain recognized a novel epitope around the N-67 glycan on the E protein: a possible explanation of dengue virus evolution regarding the acquisition of N-67 glycan

2020 ◽  
Author(s):  
Tomohiro Kotaki ◽  
Atsushi Yamanaka ◽  
Eiji Konishi ◽  
Masanori Kameoka
Keyword(s):  
Monoclonal Antibody ◽  
Dengue Virus ◽  
Vaccine Development ◽  
Selective Pressure ◽  
Protein A ◽  
Conformational Epitope ◽  
Mouse Monoclonal Antibody ◽  
Dengue Vaccine ◽  
E Protein

AbstractAnalysis of the neutralizing epitope of dengue virus (DENV) is important for the development of an effective dengue vaccine. A potent neutralizing mouse monoclonal antibody named 7F4 was previously reported and, here, we further analyze the detailed epitope of this antibody. 7F4 recognized a novel conformational epitope close to the N-67 glycan on the E protein. This antibody was specific to the DENV that lacks N-67 glycan, including the Mochizuki strain. Interestingly, the Mochizuki strain acquired N-67 glycan by 7F4 selective pressure. DENVs might have evolved to escape from this antibody considering that most of currently circulating DENVs possess N-67 glycan. However, this suggests that 7F4 epitope might be useless as a vaccine target. Nevertheless, this study demonstrated the existence of epitopes competing for 7F4 epitope, which are involved in neutralization. This study describes the importance of antibodies recognizing epitopes near the N-67 glycan for future dengue vaccine development.

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