Central role of T lymphocytes in specific recognition of tumor antigens in 51Cr-leukocyte adherence inhibition

1982 ◽  
Vol 73 (2) ◽  
pp. 365-375 ◽  
Author(s):  
P.H. Tsang ◽  
J.F. Holland ◽  
J.G. Bekesi
Keyword(s):  
T Lymphocytes ◽  
Tumor Antigens ◽  
Leukocyte Adherence ◽  
Specific Recognition ◽  
Leukocyte Adherence Inhibition ◽  
Adherence Inhibition

Leukocyte Adherence Inhibition Test: Cell-Mediated Reactivity to Tumor Antigens in Colorectal and Lung Tumor Long Survivors

1991 ◽  
Vol 77 (6) ◽  
pp. 500-505
Author(s):  
Massimo Fazio ◽  
Felice Calabrese ◽  
Michele Camandona ◽  
Franco Correggia ◽  
Sara Giacomasso ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Tumor Antigens ◽  
Lung Tumor ◽  
Prognostic Significance ◽  
Lung Squamous Cell Carcinoma ◽  
Cell Mediated Immunity ◽  
Leukocyte Adherence ◽  
Leukocyte Adherence Inhibition ◽  
Blocking Factors ◽  
Adherence Inhibition

Cell-mediated Immunity versus tumor antigens (cytosols) of the same histotype and site was evaluated by means of the leukocyte adherence Inhibition (LAI) test in 44 colorectal adenocarcinoma and 17 lung squamous-cell carcinoma patients 3–10 years after surgical resection. LAI-positivity was observed in 17/44 (38.6 %) and 13/17 (76.5 %) patients, respectively, together with serum blocking factors in 7/17 (41.2%) compared to 0/13. These results indicate that a high percentage of long survivors retain an immunologic memory of the tumor antigen to which they have been exposed. The prognostic significance of serum blocking factors is less clear.

Tube Leukocyte Adherence-Inhibition Response to Related and Unrelated Tumor Antigens in Mammary Tumor-Bearing Mice

1983 ◽  
Vol 69 (4) ◽  
pp. 299-303 ◽  
Author(s):  
Utpala Chattopadhyay ◽  
Surajit Guha
Keyword(s):  
Mammary Tumor ◽  
Tumor Antigens ◽  
Ehrlich Ascites Carcinoma ◽  
Tumor Burden ◽  
Leukocyte Adherence ◽  
Tumor Bearing ◽  
Inhibition Response ◽  
Ehrlich Ascites ◽  
Leukocyte Adherence Inhibition ◽  
Adherence Inhibition

Tube leukocyte adherence-inhibition response to syngeneic mammary tumor antigens and alloantigens from Ehrlich ascites carcinoma and fibrosarcoma was studied in spontaneous mammary tumor-bearing C3H/Jax mice. The mice with limited tumor burden responded significantly to the mammary tumor antigen and the Ehrlich ascites carcinoma antigen. The reactivity disappeared with increased tumor load. Oscillatory responses in leukocyte adherence inhibition to the reactive antigens was observed with increasing tumor weight. There was no response to the alloantigen of fibrosarcoma.

The Role of Acupuncture in Asthma: Changes in Airways Dynamics and LTC4 Induces LAI

1989 ◽  
Vol 17 (03n04) ◽  
pp. 129-134 ◽  
Author(s):  
M. Sternfeld ◽  
A. Fink ◽  
Z. Bentwich ◽  
A. Eliraz
Keyword(s):  
Medical Treatment ◽  
Acupuncture Treatment ◽  
Total Serum ◽  
Induced Responses ◽  
Leukocyte Adherence ◽  
Skin Reactivity ◽  
Leukocyte Adherence Inhibition ◽  
Asthma Patients ◽  
Adherence Inhibition

A cohort of nine extrinsic asthma patients were treated by means of acupuncture. Patients were followed up for changes in medical treatment, spirometry, skin reactivity to immediate type reactions, total serum IgE levels and reactivity of their leukocytes to leukotriene C4 challenge (LTC4 induced leukocyte adherence inhibition (LAI) assay). Our results show that after acupuncture, treated patients were able to reduce bronchodilator and taper completely corticosteroid therapy. No change in skin reactivity or in IgE levels were noted. However, acupuncture treatment was able to negate, in 66.6%, the positive LTC4 induced responses.

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