Simultaneous determination of p-aminobenzoic acid, acetyl-p-aminobenzoic acid and p-aminohippuric acid in serum and urine by capillary gas chromatography with use of a nitrogen-phosphorus detector

1981 ◽  
Vol 115 (2) ◽  
pp. 119-123 ◽  
Author(s):  
Jean-Claude Libeer ◽  
Simon L. Scharpé ◽  
Robert M. Verkerk ◽  
AndréJ. Deprettere ◽  
Paul J. Schepens
Keyword(s):  
Gas Chromatography ◽  
Simultaneous Determination ◽  
Capillary Gas Chromatography ◽  
Aminobenzoic Acid ◽  
Nitrogen Phosphorus Detector ◽  
Nitrogen Phosphorus ◽  
Serum And Urine

Determination of Acidic Herbicides and Related Compounds in Water and Soil by Capillary Gas Chromatography Using a Nitrogen-Phosphorus Detector

1989 ◽  
Vol 72 (2) ◽  
pp. 365-367 ◽  
Author(s):  
Abdul W Ahmed ◽  
Victorin N Mallet ◽  
Michel J Bertrand
Keyword(s):  
Gas Chromatography ◽  
Coefficient Of Variation ◽  
Capillary Gas Chromatography ◽  
Resin Column ◽  
Average Coefficient ◽  
Acidic Herbicides ◽  
Nitrogen Phosphorus Detector ◽  
Related Compounds ◽  
Nitrogen Phosphorus

Abstract Methods are described for the determination of acidic herbicides and related compounds in water and soil. Eight acidic herbicides and related compounds were extracted from water using either dichloromethane or an XAD-2 resin column. The acidic moieties were derivatized with 2-cyanoethyldimethyl(diethyl)aminosilane. The derivatized compounds were separated using capillary gas chromatography and quantitated using a nitrogen-phosphorus detector. Extraction from water using dichloromethane or an XAD-2 resin column resulted in recoveries > 90% at 0.1 ppb with an average coefficient of variation (CV) of 6%. In soils extracted with aqueous acetonitrileacetic acid and partitioned into dichloromethane, recoveries at 500 ppb were > 75% with an average CV of 3.3%. The methods are rapid and there are few interferences.

Screening and quantification of hypnotic sedatives in serum by capillary gas chromatography with a nitrogen-phosphorus detector, and confirmation by capillary gas chromatography-mass spectrometry.

1986 ◽  
Vol 32 (2) ◽  
pp. 325-328 ◽  
Author(s):  
V A Soo ◽  
R J Bergert ◽  
D G Deutsch
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Capillary Gas Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Detector Response ◽  
Capillary Gc ◽  
Chromatography Mass Spectrometry ◽  
Nitrogen Phosphorus Detector ◽  
Sedative Drugs ◽  
Nitrogen Phosphorus

Abstract We describe a quantitative screen for hypnotic-sedative drugs in which we use capillary gas chromatography with a nitrogen-phosphorus detector (GC/NPD) as the primary method and capillary gas chromatography-mass spectrometry (GC-MS) for confirmation. GC retention times of the acid-extracted underivatized drugs were stable (CVs less than 1%), and the detector response varied linearly over a 20-fold concentration range with a mean correlation coefficient for 11 drugs of 0.989. The limits of detection were satisfactory (0.5 mg/L in a 0.5-mL serum sample and 1-microL injection volume), as were precision (average CV 5.2% within day, 6.4% between day). The complementary use of capillary GC-MS not only unambiguously confirms presumptive peaks identified by GC, but also prevents reports of false positives and identifies compounds not included in the quantitative GC screen that may be listed in the GC-MS library.

Sign in / Sign up

Export Citation Format

Share Document