Monte Carlo investigation of electron fluence perturbation in MRI-guided radiotherapy beams using six commercial radiation detectors

With the integration of MRI-linacs to the clinical workflow, the understanding and characterization of detector response in reference dosimetry in magnetic fields are required. The magnetic field perturbs the electron fluence (Fe), and the degree of perturbation depends on the irradiation conditions and the detector type. This work evaluates the magnetic field impact on the electron fluence spectra in several detectors to provide a deeper understanding of detector response in these conditions. Monte Carlo calculations of Fe are performed in six detectors (solid-state: PTW60012 and PTW60019, ionization chambers: PTW30013, PTW31010, PTW31021, and PTW31022) placed in water and irradiated by an Elekta Unity 7 MV FFF photon beam with small and reference fields, at 0 T and 1.5 T. Three chamber-axis orientations are investigated: parallel or perpendicular (two possibilities: FL towards the stem or the tip) to the magnetic field and perpendicular to the beam. One orientation for the solid-state detector is studied: parallel to the beam and perpendicular to the magnetic field. Additionally, Fe spectra are calculated in modified detector geometries to identify the underlying physical mechanisms behind the fluence perturbations. The total Fe is reduced up to 1.24% in the farmer chamber, at 1.5 T, in the parallel orientation. The interplay between the gyration radius and the farmer chamber cavity length significantly affects Fe in the perpendicular orientation; the total fluence varies up to 5.12% in magnetic fields. For the small-cavity chambers, the maximal variation in total Fe is 0.19%, for the reference field, in the parallel orientation. . In contrast, significant small-field effects occur; the total Fe is reduced between 9.86% to 14.50% at 1.5T (with respect to 0T) depending on the orientation. The magnetic field strongly impacted the solid-state detectors in both field sizes, probably due to the high-density extracameral components. The maximal reductions of total Fe are 15.06±0.09% (silicon) and 16.00±0.07% (microDiamond). This work provides insights into detector response in magnetic fields by illustrating the interplay between several factors causing dosimetric perturbation effects: 1) chamber and magnetic field orientation, 2) cavity size and shape, 3) extracameral components, 4) air gaps and their asymmetry, 5) electron energy. Low-energy electron trajectories are more susceptible to change in magnetic fields, and generally, they are associated with detector response perturbation.

Core-collapse Supernova Simulations and the Formation of Neutron Stars, Hybrid Stars, and Black Holes

We investigate observable signatures of a first-order quantum chromodynamics (QCD) phase transition in the context of core-collapse supernovae. To this end, we conduct axially symmetric numerical relativity simulations with multi-energy neutrino transport, using a hadron–quark hybrid equation of state (EOS). We consider four nonrotating progenitor models, whose masses range from 9.6 to 70 M ⊙. We find that the two less-massive progenitor stars (9.6 and 11.2 M ⊙) show a successful explosion, which is driven by the neutrino heating. They do not undergo the QCD phase transition and leave behind a neutron star. As for the more massive progenitor stars (50 and 70 M ⊙), the proto-neutron star (PNS) core enters the phase transition region and experiences the second collapse. Because of a sudden stiffening of the EOS entering to the pure quark matter regime, a strong shock wave is formed and blows off the PNS envelope in the 50 M ⊙ model. Consequently the remnant becomes a quark core surrounded by hadronic matter, leading to the formation of the hybrid star. However, for the 70 M ⊙ model, the shock wave cannot overcome the continuous mass accretion and it readily becomes a black hole. We find that the neutrino and gravitational wave (GW) signals from supernova explosions driven by the hadron–quark phase transition are detectable for the present generation of neutrino and GW detectors. Furthermore, the analysis of the GW detector response reveals unique kHz signatures, which will allow us to distinguish this class of supernova explosions from failed and neutrino-driven explosions.

Light yield and field dependence measurement in PandaX-II dual-phase xenon detector

The dual-phase xenon time projection chamber (TPC) is one of the most sensitive detector technology for dark matter direct search, where the energy deposition of incoming particle can be converted into photons and electrons through xenon excitation and ionization. The detector response to signal energy deposition varies significantly with the electric field in liquid xenon. We study the detector's light yield and its dependence on the electric field in the PandaX-II dual-phase detector containing 580 kg liquid xenon in the sensitive volume. From our measurements, the light yield at electric fields from 0 V/cm to 317 V/cm is obtained for energy depositions up to 236 keV.

Xenon doping of liquid argon in ProtoDUNE single phase

The Deep Underground Neutrino Experiment (DUNE) will be the next generation long-baseline neutrino experiment. The far detector is designed as a complex of four LAr-TPC (Liquid Argon Time Projection Chamber) modules with 17 kt of liquid argon each. The development and validation of the first far detector technology is pursued through ProtoDUNE Single Phase (ProtoDUNE-SP), a 770 t LAr-TPC at CERN Neutrino Platform. Crucial in DUNE is the photon detection system that will ensure the trigger of non-beam events — proton decay, supernova neutrino burst and BSM searches — and will improve the timing and calorimetry for neutrino beam events. Doping liquid argon with xenon is a known technique to shift the light emitted by argon (128 nm) to a longer wavelength (178 nm) to ease its detection. The largest xenon doping test ever performed in a LAr-TPC was carried out in ProtoDUNE-SP. From February to May 2020, a gradually increasing amount of xenon was injected to also compensate for the light loss due to air contamination. The response of such a large TPC has been studied using the ProtoDUNE-SP Photon Detection System (PDS) and a dedicated setup installed before the run. With the first it was possible to study the light collection efficiency with respect to the track position, while with the second it was possible to distinguish the xenon light (178 nm) from the LAr light (128 nm). The light shifting mechanism proved to be highly efficient even at small xenon concentrations (<20 ppm in mass) furthermore it allowed recovering the light quenched by pollutants. The light collection improved far from the detection plane, enhancing the photon detector response uniformity along the drift direction and confirming a longer Rayleigh scattering length for 178 nm photons, with respect to 128 nm ones. The charge collection by the TPC was monitored proving that xenon up to 20 ppm does not impact its performance.

Simulated sensor characterization for virtual clinical trials in mammography and digital breast tomosynthesis

Virtual clinical trials in X-ray breast imaging permit to compare different technical solutions and imaging modalities at reduced costs, involved personnel, reduced times and reduced radiation risks to patients. In this context, the detector characteristics (spatial resolution, noise level and efficiency) play a key role for an appropriate generation of simulated images. The project AGATA proposes to compute images as dose deposit maps in a detector layer of defined materials. Simulated images are then post-processed on the basis of suitable comparison between intrinsic characteristics of real and simulated detectors. With this scope, as first step for the post-processing manipulations, we evaluated the presampled modulation transfer function (MTF), the detector-response function and the noise power spectrum (NPS) of the simulated detectors. Two detectors were simulated: (1) 0.20 mm-thick a-Se direct flat panel with 70 µm pixel pitch and (2) CsI(Tl) indirect flat panel with 100 µm pixel pitch and scintillator layer 0.25 mm thick. In addition, the impact of simulating the de-excitation processes (Auger emission and fluorescence) was explored. Simulated detector characteristics were evaluated for W/Rh spectra between 25 kV and 31 kV. The in-silico platform used a Monte Carlo software based on Geant4 toolkit (vers. 6). First, the simulation and tracking of electrons generated from photoelectric or Compton interactions was shown to have neglectable influence on the pixel values for the explored spectra, with the produced electrons presenting short ranges with respect to the pixel dimension. In the case of the CsI detector, which has fluorescence energies higher than those of the simulated X-ray photons, the deexcitation processes have not noticeable influence on the calculated pixel values. On the other hand, the MTF of the a-Se detector resulted slightly lower when the fluorescence is simulated in the detector materials, due to the dose spread derived from the fluorescence photons, which can travel far from the initial ionization interaction. Regarding the a-Se detector, the noise power spectrum resulted lower with simulated deexcitation.

Studies on the Impact of Hydrogen on the Results of THT Measurement Devices

An essential prerequisite for safe transport and use of natural gas is their appropriate odorization. This enables the detection of uncontrolled gas leaks. Proper and systematic odorization inspection ensures both safe use of gas and continuity of the process itself. In practice, it is conducted through, among others, measuring odorant concentrations in gas. Control devices for rapid gas odorization measurements that are currently used on a large scale in the gas industry are equipped with electrochemical detectors selective for sulfur compounds like tetrahydrothiophene (THT). Because the selectivity of electrochemical detector response to one compound (e.g., THT), the available declarations of manufacturers show that detector sensitivity (indirectly also the quality of the measurement result) is influenced by the presence of increased e.g., sulfur or hydrogen compound content in the gas. Because of the lack of sufficient source literature data in this field, it was necessary to experimentally verify this impact. The results of studies on experimental verification of suspected influence of increased amounts of hydrogen in gas on the response of electrochemical detector was carried out at the Oil and Gas Institute—National Research Institute (INiG—PIB). They are presented in this article. The data gathered in the course of researching the dependence between THT concentration measurement result quality and hydrogen content in gas composition enabled a preliminary assessment of the threat to the safety of end users of gaseous fuels caused by the introduction of this gas into the distribution network. Noticing the scope of necessary changes in the area of odorization is necessary to guarantee this safety.

Medical Range Radiation Dosimeter Based on Polymer-Embedded Fiber Bragg Gratings

Fiber Bragg gratings (FBGs) are valuable dosimeters for doses up to 100 kilograys (kGy), but have hardly been used for the low-dose range of a few grays (Gy) required in medical radiation dosimetry. We report that embedding a doped silica fiber FBG in a polymer material allows a minimum detectable dose of 0.3 Gy for γ-radiation. Comparing the detector response for different doped silica fibers with various core doping, we obtain an independent response, in opposition to what is reported for high-dose range. We hypothesized that the sensor detection is based on the radio-induced thermal expansion of the surrounding polymer. Hence, we used a simple physical model based on the thermal and mechanical properties of the surrounding polymer and obtained good accordance between measured and calculated values for different compositions and thicknesses. We report that over the 4 embedding polymers tested, polyether ether ketone and polypropylene have respectively the lowest (0.056 pm/Gy) and largest sensitivity (0.087 pm/Gy). Such FBG-based dosimeters have the potential to be distributed along the fiber to allow multipoint detection while having a sub-millimeter size that could prove very useful for low-dose applications, in particular for radiotherapy dosimetry.

Benchmarking LHC background particle simulation with the CMS triple-GEM detector

In 2018, a system of large-size triple-GEM demonstrator chambers was installed in the CMS experiment at CERN's Large Hadron Collider (LHC). The demonstrator's design mimicks that of the final detector, installed for Run-3. A successful Monte Carlo (MC) simulation of the collision-induced background hit rate in this system in proton-proton collisions at 13 TeV is presented. The MC predictions are compared to CMS measurements recorded at an instantaneous luminosity of 1.5 ×1034 cm-2 s-1. The simulation framework uses a combination of the FLUKA and GEANT4 packages. FLUKA simulates the radiation environment around the GE1/1 chambers. The particle flux by FLUKA covers energy spectra ranging from 10-11 to 104 MeV for neutrons, 10-3 to 104 MeV for γ's, 10-2 to 104 MeV for e±, and 10-1 to 104 MeV for charged hadrons. GEANT4 provides an estimate of the detector response (sensitivity) based on an accurate description of the detector geometry, the material composition, and the interaction of particles with the detector layers. The detector hit rate, as obtained from the simulation using FLUKA and GEANT4, is estimated as a function of the perpendicular distance from the beam line and agrees with data within the assigned uncertainties in the range 13.7-14.5%. This simulation framework can be used to obtain a reliable estimate of the background rates expected at the High Luminosity LHC.

Radiation hardness of PantherPix hybrid pixel detector

Hybrid pixel detectors (HPD) are nowadays well known and widely used in fundamental research, e.g. in high energy physics experiments. Over the last decade, segmented semiconductor detectors have also found use in medicine. The total doses received by medical radiation detectors often reach a significant level (up to several hundreds of kGy per decade), especially in applications such as transmission portal in-vivo dosimetry. Such doses might affect detector properties. Therefore, it is necessary to evaluate their performance after absorbing a significant radiation dose. PantherPix is a novel 2D hybrid pixel detector which is designed specifically for use in radiation therapy. As was concluded in earlier studies, it is suitable for radiotherapy quality assurance (QA) and portal dosimetry. In this paper, the PantherPix radiation hardness is investigated using a 60Co source. The dependence on dose of the full depletion voltage, leakage current, detector power consumption and detector response are provided. The PantherPix radiation tolerance has been shown to be adequate for common cumulative doses delivered to radiation detectors in radiotherapy over several decades and its performance has been verified for doses up to 3000 kGy.

Systematic end-to-end testing of multiple target treatments using the modular RUBY phantom

The RUBY head phantom in combination with the System QA insert MultiMet can be used for simultaneous point dose measurements at an isocentric and two off-axis positions. This study investigates the suitability of the system for systematic integral end-to-end testing of single-isocenter multiple target stereotactic treatments. Several volumetric modulated arc therapy plans were optimized on a planning CT of the phantom positioned in a stereotactic mask on the stereotactic treatment board. The plans were created for three artificial spherical target volumes centred around the measurement positions in the MultiMet insert. Target diameters between 5 and 40 mm were investigated. Coplanar and non-coplanar plans were optimized using the collapsed cone algorithm of the Oncentra Masterplan treatment planning system and recalculated with the Monte Carlo algorithm of the Monaco treatment planning system. Measurements were performed at an Elekta Synergy linear accelerator. The head phantom was positioned according to clinical workflow comprising immobilization and CBCT imaging. Simultaneous point dose measurements at all target positions were performed with three PinPoint 3D chambers (type 31022) as well as three microDiamond (type 60019) detectors and compared to the treatment planning system calculations. Furthermore, the angular dependence of the detector response was investigated to estimate the associated impact on the measured point dose values. Considering all investigated plans, PTV diameters and positions, the point doses calculated with the Monaco treatment planning system and the microDiamond measurements differed within 3.5%, whereas the PinPoint 3D showed differences of up to 6.9%. Point dose differences determined in comparison to the Oncentra Masterplan dose calculations were larger. The RUBY system was shown to be suitable for end-to-end testing of complex treatment scenarios such as single-isocenter multiple target plans.