scholarly journals Stimulation of RNA polymerase activity of rat liver nuclei by cortisol in vitro independent of effects on the acetylation and methylation of histones

FEBS Letters ◽  
1969 ◽  
Vol 3 (2) ◽  
pp. 99-102 ◽  
Author(s):  
D. Gallwitz ◽  
C.E. Sekeris
Keyword(s):  
Rna Polymerase ◽  
Rat Liver ◽  
Polymerase Activity ◽  
Rat Liver Nuclei ◽  
Rna Polymerase Activity ◽  
Liver Nuclei ◽  
Stimulation Of

scholarly journals Stimulating Effect of Panax ginseng Extract on RNA Polymerase Activity in Rat Liver Nuclei

1971 ◽  
Vol 19 (8) ◽  
pp. 1656-1663 ◽  
Author(s):  
SUSUMU HIAI ◽  
HIKOKICHI OURA ◽  
KINJI TSUKADA ◽  
YOSHIKATSU HIRAI
Keyword(s):  
Rna Polymerase ◽  
Panax Ginseng ◽  
Rat Liver ◽  
Polymerase Activity ◽  
Ginseng Extract ◽  
Rat Liver Nuclei ◽  
Rna Polymerase Activity ◽  
Liver Nuclei

scholarly journals Inhibition by α-amanitin of ribonucleic acid polymerase solubilized from rat liver nuclei

1970 ◽  
Vol 116 (2) ◽  
pp. 177-180 ◽  
Author(s):  
F. Novello ◽  
L. Fiume ◽  
F. Stirpe
Keyword(s):  
Rna Polymerase ◽  
Ammonium Sulphate ◽  
Rat Liver ◽  
Ribonucleic Acid ◽  
Isolated Rat Liver ◽  
Rat Liver Nuclei ◽  
Liver Nuclei ◽  
Isolated Rat

1. α-Amanitin inhibits in vitro the RNA polymerase solubilized from isolated rat liver nuclei. 2. In contrast with previous observations with whole nuclei, the inhibition occurs approximately to the same extent in the presence and in the absence of ammonium sulphate. 3. Evidence is presented that the toxin acts by interacting with the enzyme itself and not with DNA or other components.

scholarly journals The effects of copper and other ions on the ribonucleic acid polymerase activity of isolated rat liver nuclei

1969 ◽  
Vol 111 (1) ◽  
pp. 115-119 ◽  
Author(s):  
F. Novello ◽  
F. Stirpe
Keyword(s):  
Rna Polymerase ◽  
Ammonium Sulphate ◽  
Rat Liver ◽  
Ribonucleic Acid ◽  
Polymerase Activity ◽  
Isolated Rat Liver ◽  
Rat Liver Nuclei ◽  
Liver Nuclei ◽  
Isolated Liver ◽  
Isolated Rat

1. The effects of various ions on the Mg2+- and Mn2+/ammonium sulphate-activated RNA polymerase activities of isolated liver nuclei were studied. 2. The Mg2+-activated RNA polymerase reaction was inhibited by more than 60% by Cd2+, SeO32−, Be2+, Cu2+, Co2+, Ca2+ and La3+, all at 1mm concentrations. 3. The Mn2+/ammonium sulphate-activated RNA polymerase reaction was strongly inhibited by Hg2+, Cd2+, Cu2+ and Ag+. The effect of Hg2+, Cd2+ and Ag+ was relieved by cysteine or mercaptoethanol. 4. Inhibition by Cu2+ was not affected by addition of DNA, and was relieved only partially by EDTA or histidine. 5. No changes of RNA polymerase activities were observed in nuclei isolated from the liver of rats treated with copper albuminate.

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