Local antisecretory effect of leminoprazole on histamine-stimulated gastric acid secretion in Heidenhain pouch dogs

1995 ◽  
Vol 108 (4) ◽  
pp. A182
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Heidenhain Pouch ◽  
Antisecretory Effect

Effect of GABA on basal and vagally mediated gastric acid secretion and hormone release in dogs

1988 ◽  
Vol 254 (5) ◽  
pp. G723-G731
Author(s):  
R. C. Thirlby ◽  
M. H. Stevens ◽  
A. J. Blair ◽  
F. Petty ◽  
I. L. Crawford ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Blood Brain Barrier ◽  
Gaba Receptors ◽  
Gaba Receptor ◽  
Receptor Agonist ◽  
Acid Output ◽  
Gastric Fistula ◽  
Heidenhain Pouch

To stimulate peripheral gamma-aminobutyric acid (GABA) receptors, GABA, which does not cross the blood-brain barrier, was administered to dogs with vagally innervated gastric fistulas at intravenous doses of 0, 0.66, 2, 6, 18, and 54 micrograms.kg-1.min-1. Mean gastric acid output increased from zero basally to 3.0 +/- 1.4 mmol/h during infusion of 54 micrograms.kg-1.min-1 GABA. Plasma somatostatin-like immunoreactivity decreased significantly below basal levels during infusion of 54 micrograms.kg-1.min-1 GABA (P less than 0.05). To stimulate central nervous system GABA receptors as well as peripheral GABA receptors, progabide, a GABA-receptor agonist, which readily crosses the blood-brain barrier, was injected intravenously. Mean acid output was 3.5 +/- 1.3 mmol/h after 20 mg/kg progabide and 0.6 +/- 0.5 mmol/h after its vehicle (P less than 0.05). Basal serum gastrin concentration increased significantly after progabide injection. Acid output during insulin-induced hypoglycemia was inhibited 59% by 30 mg/kg intravenous progabide. Progabide infusion also diminished or abolished circulating gastrin, somatostatin, and pancreatic polypeptide responses during insulin-induced hypoglycemia (P less than 0.05). Further studies were performed in dogs with a gastric fistula and a vagally denervated Heidenhain pouch to confirm that GABA-receptor stimulation affects acid secretion via peripheral pathways. Intravenous injection of baclofen (0.5 mg/kg), a GABAB-receptor agonist, increased acid secretion significantly from the gastric fistula and the Heidenhain pouch. These studies suggest that GABA may play a role in regulating gastric acid secretion and gastrointestinal and pancreatic endocrine function by both central and peripheral mechanisms.

scholarly journals Antisecretory Effect of Hydrogen Sulfide on Gastric Acid Secretion and the Involvement of Nitric Oxide

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Seyyed Ali Mard ◽  
Hasan Askari ◽  
Niloofar Neisi ◽  
Ali Veisi
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Acid Output ◽  
Control Group ◽  
Antisecretory Effect ◽  
Cox 2 ◽  
Stimulation Of

The present study was designed to investigate the effect of H2S on distention-induced gastric acid secretion. Fifty-two rats were randomly assigned to seven experimental groups. The gastric acid secretion was stimulated by gastric distention. Two groups of rats received L-cysteine or saline for 5 days before stimulation of the gastric acid secretion. Two groups of animals also received NaHS or saline just prior to stimulation of the gastric acid secretion. The effect of L-NAME and propargylglycine was also investigated. The mucosal levels of the gene expression of cyclooxygenase-2 (COX-2), endothelial nitric oxide synthase (eNOS), and H+/K+-ATPaseα-subunit were quantified by qPCR and luminal concentrations of NO were determined. NaHS and L-cysteine decreased the gastric acid output in response to distention. The mRNA expression of H+/K+-ATPaseα-subunit decreased by NaHS and L-cysteine as compared with the control group while gene expression of eNOS and COX-2 was upregulated. The inhibitory effect of NaHS on distention-induced gastric acid secretion was mitigated by pretreatment of L-NAME. These findings suggest the involvement of NO in mediating the antisecretory effect of H2S.

scholarly journals Local inhibitory effect of leminoprazole on histamine-stimulated gastric acid secretion in Heidenhain pouch dogs

1997 ◽  
Vol 73 ◽  
pp. 77
Author(s):  
Jun-ichi Shigeta ◽  
Takuya Tsukahara ◽  
Hiroyuki Harada ◽  
Satoru Takahashi ◽  
Shiho Okano ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Inhibitory Effect ◽  
Heidenhain Pouch
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