Further studies on the gas-liquid chromatographic determination of C10 steroids in human plasma using nickel-63 electron capture detection

Gas Liquid Chromatography ◽

Abstract A procedure is described for the gas-liquid chromatographic determination of sulfathiazole, sulfamerazine, sulfamethazine, and sulfaquinoxaline in finished feeds at levels from 0.002 to 0.05%. The procedure utilizes a double derivatization technique to modify the sulfonamides so that they can be determined by gas-liquid chromatography with electron capture detection. The conditions for extraction, derivatization, and gas-liquid chromatography are given, along with recovery data.

Gas—liquid chromatographic determination of flurazepam and its major metabolites in plasma with electron-capture detection

Journal of Chromatography B Biomedical Sciences and Applications ◽

10.1016/s0378-4347(00)81857-5 ◽

1982 ◽

Vol 231 (2) ◽

pp. 321-331 ◽

Cited By ~ 10

Author(s):

Sam F. Cooper ◽

Daniel Drolet

Keyword(s):

Electron Capture ◽

Gas—liquid chromatographic determination of methohexital in plasma or whole blood with electron-capture detection of the pentafluorobenzyl derivative

Journal of Chromatography B Biomedical Sciences and Applications ◽

10.1016/s0378-4347(00)84803-3 ◽

1983 ◽

Vol 278 ◽

pp. 424-428 ◽

Cited By ~ 3

Author(s):

Sven Björkman ◽

Jan Idvall ◽

P»l Stenberg

Keyword(s):

Electron Capture ◽

Whole Blood ◽

Modified Method for Electron Capture Gas-Liquid Chromatographic Determination of Hexestrol Residues in Bovine Tissues

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/61.5.1054 ◽

1978 ◽

Vol 61 (5) ◽

pp. 1054-1057

Author(s):

Hisaya Tobioka ◽

Ryoji Kawashima

Keyword(s):

Electron Capture ◽

Purification Step ◽

Packing Materials ◽

Modified Method ◽

Extraction And Purification ◽

Abstract A gas-liquid chromatographic (GLC) method with electron capture detection was developed for determining hexestrol residues based on a GLC method for diethylstilbestrol residues. The extraction and purification procedures were based on a published procedure. Pentafluoropropionic (PFP) and heptafluorobutyric (HFB) anhydrides and other halogenated compounds were compared as acylation reagents. PFP anhydride was selected because it provided reproducible GLC responses. Of the 3 column packing materials tested, OV-17, OV-210, and QF-1, OV-17 was the most stable under the GLC conditions used. A pH 10.5—10.6 in the purification step gave higher recoveries than pH 10.3 or pH 10.8 and was selected for use. The method is suitable for determining residues of 0.5 ppb. The limit of sensitivity ranges from 0.1 to 0.2 ppb.

Gas-Liquid Chromatographic Determination of Technical Chlordane Residues in Food Crops: Interpretation of Analytical Data

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/58.5.1051 ◽

1975 ◽

Vol 58 (5) ◽

pp. 1051-1061

Author(s):

William P Cochrane ◽

James F Lawrence ◽

Young W Lee ◽

Ronald B Maybury ◽

Brian P Wilson

Keyword(s):

Field Experiments ◽

Stationary Phases ◽

Analytical Data ◽

Food Crops ◽

Consistent Method ◽

Abstract An interlaboratory investigation of technical chlordane residues in food crops was carried out to determine the most practical and consistent method of reporting results. Using a technical chlordane reference standard, 8 gas chromatographic stationary phases were studied for their resolution capabilities. The best separations were obtained with SE-30 and its OV-1 equivalent. Using these columns and electron capture detection, potatoes and carrots from supervised field experiments were analyzed in duplicate and quantitated by using 4 methods of calculation. The data were statistically treated to determine the precision and bias for each method. Also, 1 sample was analyzed in duplicate on 2 different occasions by 6 laboratories to substantiate the initial conclusions. Based on the criterion of high precision it is suggested that a comparison of total area under the chromatogram of the sample with total area of a standard technical chlordane be the method of quantitation. Only peaks which are common to both standard and sample have any significance in this type of calculation.