Application of modified cyclodextrins in capillary electrophoresis for enantiomeric resolution of propranolol and analogues

1995 ◽  
Vol 705 (2) ◽  
pp. 351-361 ◽  
Author(s):  
M.W. Matchett ◽  
S.K. Branch ◽  
T.M. Jefferies
Keyword(s):  
Capillary Electrophoresis ◽  
Enantiomeric Resolution ◽  
Modified Cyclodextrins

Enantiomeric resolution of multiple chiral centres racemates by capillary electrophoresis

2016 ◽  
Vol 30 (5) ◽  
pp. 683-694 ◽  
Author(s):  
Imran Ali ◽  
Mohd. Suhail ◽  
Zeid A. AL-Othman ◽  
Abdulrahman Alwarthan ◽  
Hassan Y. Aboul-Enein
Keyword(s):  
Capillary Electrophoresis ◽  
Enantiomeric Resolution

Modified cyclodextrins for fast and sensitive chiral-capillary electrophoresis-mass spectrometry

2009 ◽  
Vol 30 (10) ◽  
pp. 1734-1742 ◽  
Author(s):  
Alessandro Giuffrida ◽  
Carlos León ◽  
Virginia García-Cañas ◽  
Vincenzo Cucinotta ◽  
Alejandro Cifuentes
Keyword(s):  
Mass Spectrometry ◽  
Capillary Electrophoresis ◽  
Modified Cyclodextrins ◽  
Chiral Capillary Electrophoresis ◽  
Capillary Electrophoresis Mass Spectrometry

scholarly journals Molecular Modeling and Chiral Separation of Benzodiazepines by Capillary Electrophoresis Using Highly Sulfated Cyclodextrins

2018 ◽  
Vol 62 (2) ◽  
Author(s):  
María Gabriela Vargas Martinez ◽  
Guillermo Ramírez Galicia
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Theoretical Study ◽  
Equilibrium Constants ◽  
Fractional Factorial ◽  
Organic Modifier ◽  
Enantiomeric Resolution ◽  
Electrophoretic Method ◽  
Capillary Electrophoretic ◽  
Separation Conditions

<p>A capillary electrophoretic method for the chiral separation of the 3-chiral-1,4-benzodiazepines was developed. Enantiomeric resolution of oxazepam, lorazepam, temazepam, and lormetazepam was achieved using sulfated cyclodextrins (CD's) as chiral selectors. A 3-levels, 4-factors fractional factorial (34-2) design was applied to test 3 different CD's: heptakis-6-sulfato--cyclodextrin (HSCD), heptakis-(2,3-diacetyl-6-sulfato)--cyclodextrin (HDASCD), and heptakis-(2,3-dimethyl-6-sulfato)--cyclodextrin (HDMSCD). The CD type, its concentration, the pH of the electrolyte, and % organic modifier were tested as the factors in the experimental design. The highest resolution values were obtained using a 20 mM borate buffer, pH 9.0 with the addition of 5 % HSCD and 15 % methanol as an organic modifier. At these separation conditions, the equilibrium constants of the benzodiazepine-HSCD complex formation were calculated. A theoretical study of the interaction benzodiazepine-HSCD complex using semiempirical calculations is postulated.</p>

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