Effects of portacaval shunt and hepatic artery ligation on liver surface oxygen tension and effective hepatic blood flow

1987 ◽  
Vol 42 (1) ◽  
pp. 7-9 ◽  
Author(s):  
Howard N. Sankary ◽  
Eric B. Rypins ◽  
Kenneth Waxman ◽  
Judith Whang ◽  
Janice Drew ◽  
...  
1998 ◽  
Vol 275 (1) ◽  
pp. H243-H249 ◽  
Author(s):  
Hiromu Kazuo ◽  
Toshirou Nishida ◽  
Akitoshi Seiyama ◽  
Shigeyuki Ueshima ◽  
Eisaku Hamada ◽  
...  

Hepatic tissue perfusion and O2 supply after ischemia are indispensable for recovery of cellular functions, but few studies have been performed regarding the recovery of tissue blood flow and O2 transport. After 5, 15, and 30 min of ischemia of rat livers, hepatic tissue perfusion, hepatic arterial and portal blood flow, plasma[Formula: see text], and O2 transport parameters were measured. Hepatic tissue blood flow and erythrocyte velocity in the sinusoids showed biphasic recoveries after temporal ischemia for 5, 15, and 30 min. The first peak in the flow appeared at 3–4 min after the initiation of tissue perfusion, and the second peak appeared at ∼20 min, irrespective of the ischemic period. Hepatic blood flow during the initial increase contained relatively low O2-saturated blood compared with that in the second increase. Livers that had been subjected to a prior hepatic artery ligation only showed the first peak at ∼4 min. The first increase in hepatic blood flow corresponded to the peak in the portal venous flow, and the second increase corresponded to that of the hepatic artery. These results suggested that hepatic microcirculation after temporary hepatic ischemia showed biphasic recoveries because of different restoration patterns of the portal vein and hepatic artery.


1991 ◽  
Vol 51 (3) ◽  
pp. 267-270 ◽  
Author(s):  
Schmuel Katz ◽  
Marcus A. Jimenez ◽  
William E. Lehmkuhler ◽  
Jay L. Grosfeld

1992 ◽  
Vol 50 (2) ◽  
pp. 70-76 ◽  
Author(s):  
Peter Naredi ◽  
Per Lindér ◽  
Stig B. Holmberg ◽  
Rigmor Söderberg ◽  
Göran Carlsson ◽  
...  

1953 ◽  
Vol 137 (4) ◽  
pp. 507-515 ◽  
Author(s):  
Gerard Desforges ◽  
Alexander J. A. Campbell ◽  
Stanley L. Robbins

1973 ◽  
Vol 178 (2) ◽  
pp. 162-172 ◽  
Author(s):  
JOSEPH C. FORTNER ◽  
ROBERT J. MULCARE ◽  
ARlEL SOLIS ◽  
ROBIN C. WATSON ◽  
ROBERT B. COLBEY

HPB Surgery ◽  
1996 ◽  
Vol 9 (4) ◽  
pp. 245-248 ◽  
Author(s):  
F. Jakab ◽  
Z. Ráth ◽  
F. Schmal ◽  
P. Nagy ◽  
J. Faller

Data regarding the afferent circulation of the liver in patients with primary hepatocellular carcinoma are controversial, we have carried out measurement of hepatic arterial and portal venous flow intraoperatively by transit time ultrasonic volume flowmetry. In patients with primary hepatocellular carcinoma the hepatic artery flow increased to 0.55±0.211 compared with the control value of 0.37±0.102 1/min. (p<0.01). The portal venous flow decreased from 0.61±0.212 l/min, to 0.47±l/min. p<0.01). Due to the opposite changes in the afferent circulation the total hepatic blood flow did not change significantly, compared with controls.The ratio of hepatic arterial flow to portal vein flow increased to 1.239±0.246 in patients with hepatocellular carcinoma, which is double of the control value (0.66±0.259 l/min). After resection this ratio did not change.The resection did not alter hepatic artery or portal venous flow significantly, although the total hepatic blood flow decreased significantly (p<0.01).On the basis of our early results it is possible that the ratio of the two circulations may be to deel measured with doppler ultrasound and provide diagnostic information.


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