Effect of capsaicin on gastric mucosal injury and blood flow following bile acid exposure

1992 ◽  
Vol 52 (6) ◽  
pp. 596-600 ◽  
Author(s):  
Theodore R. Sullivan ◽  
Richard Milner ◽  
Daniel T. Dempsey ◽  
Wallace P. Ritchie
Keyword(s):  
Blood Flow ◽  
Bile Acid ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Acid Exposure

scholarly journals Role of capsaicin sensitive nerves in epidermal growth factor effects on gastric mucosal injury and blood flow

Gut ◽  
1998 ◽  
Vol 42 (3) ◽  
pp. 344-350 ◽  
Author(s):  
J Y Kang ◽  
C H Teng ◽  
F C Chen ◽  
A Wee
Keyword(s):  
Blood Flow ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Gastric Mucosal Damage ◽  
Arterial Infusion ◽  
Epidermal Growth

Background—Epidermal growth factor (EGF) and capsaicin protect against experimental gastric mucosal injury. Capsaicin exerts its gastroprotective effect by stimulating afferent neurones leading to release of calcitonin gene related peptide (CGRP) which causes gastric hyperaemia. EGF also causes gastric hyperaemia but whether it acts via capsaicin sensitive neurones is unknown.Aims—To assess the influence of: (1) capsaicin desensitisation on EGF effects on gastric mucosal injury and gastric mucosal blood flow; and (2) close arterial infusion of hCGRP8–37, a CGRP antagonist, on EGF effects on gastric mucosal blood flow.Methods—The absolute ethanol induced gastric mucosal injury model in the rat was used. Gastric mucosal damage was assessed by planimetry and light microscopy. Gastric mucosal blood flow was measured by laser Doppler flowmetry in a gastric chamber preparation.Results—Capsaicin desensitisation abolished the gastroprotective and gastric hyperaemic effects of EGF. Close arterial infusion of hCGRP8–37 antagonised the hyperaemic effect of both capsaicin and EGF.Conclusion—Results show that EGF may exert its gastroprotective and gastric hyperaemic effects via capsaicin sensitive afferent neurones.

Mucosal Blood Flow Stasis and Hypoxemia as the Pathogenesis of Acute Gastric Mucosal Injury

1990 ◽  
Vol 12 ◽  
pp. S85-S91 ◽  
Author(s):  
Shingo Tsuji ◽  
Sunao Kawano ◽  
Nobuhiro Sato ◽  
Takenobu Kamada
Keyword(s):  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Flow Stasis

Topical Prostaglandin E2 and Isoproterenol Reduce Bile Acid-Induced Gastric Mucosal Injury in Shocked Rats

1994 ◽  
Vol 56 (2) ◽  
pp. 184-191 ◽  
Author(s):  
David W. Mercer ◽  
Merick S. Kirshner ◽  
Wallace P. Ritchie ◽  
Daniel T. Dempsey
Keyword(s):  
Bile Acid ◽  
Prostaglandin E2 ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury

Effects of Polyunsaturated Fatty Acids on Bile Acid-Induced Gastric Mucosal Injury

1996 ◽  
Vol 61 (1) ◽  
pp. 44-50 ◽  
Author(s):  
David W. Mercer ◽  
Wallace P. Ritchie, Jr. ◽  
Daniel T. Dempsey
Keyword(s):  
Fatty Acids ◽  
Bile Acid ◽  
Polyunsaturated Fatty Acids ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury

Leukotriene receptor blockade reduces bile acid-induced superficial gastric mucosal injury

1991 ◽  
Vol 50 (6) ◽  
pp. 602-608 ◽  
Author(s):  
David W. Mercer ◽  
Richard Milner ◽  
Scott O'Neill ◽  
Wallace P. Ritchie ◽  
Daniel T. Dempsey
Keyword(s):  
Bile Acid ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Receptor Blockade ◽  
Leukotriene Receptor
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