The effect of L-α-methyl dopa and N-2-hydroxybenzyl-N-methyl hydrazine (NSD 1039) on the blood pressure of renal hypertensive rats

Life Sciences ◽  
1963 ◽  
Vol 2 (3) ◽  
pp. 193-197 ◽  
Author(s):  
Ruth A. Davis ◽  
D.J. Drain ◽  
M. Horlington ◽  
R. Lazare ◽  
Alicja Urbanska
Keyword(s):  
Blood Pressure ◽  
Hypertensive Rats ◽  
Methyl Dopa ◽  
Methyl Hydrazine ◽  
Renal Hypertensive Rats

Quantitative assay and disappearance rate of circulating renin

1964 ◽  
Vol 206 (6) ◽  
pp. 1361-1364 ◽  
Author(s):  
G. Schaechtelin ◽  
D. Regoli ◽  
F. Gross
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Pressure Increase ◽  
Disappearance Rate ◽  
Hypertensive Rats ◽  
Contralateral Kidney ◽  
Blood Pressure Increase ◽  
Hypertensive Animal ◽  
Renal Hypertensive Rats

In isovolemic cross-circulation experiments, a nephrectomized donor rat, into which various doses of hog renin were injected, was connected to a nephrectomized indicator rat. The blood pressure increase thus produced in the indicator rat was compared with the blood pressure response obtained during cross circulation using either intact normotensive or renal hypertensive rats as donor animals. An exponential dose-response relationship was found between hog renin injected into a nephrectomized donor and the blood pressure increase of the indicator rat. Using the cross-circulation technique, the disappearance rate of endogenous reninlike material in the blood of donor animals and of exogenous renin injected into nephrectomized donor animals was examined. If an intact normotensive animal or a unilaterally nephrectomized hypertensive animal is totally nephrectomized, reninlike material disappears from the blood within 1 hr. In renal hypertensive rats with an untouched contralateral kidney which have a higher concentration of reninlike material in the blood, it takes about twice the normal time until reninlike material disappears from the blood after nephrectomy. The increased and prolonged blood pressure response of the nephrectomized animal to renin is not connected with a prolonged persistence of renin in the blood.

Anti-hypertension Effects of Traditional Chinese Medicine Ju-Ling-Tang on Renal Hypertensive Rats

2005 ◽  
Vol 33 (06) ◽  
pp. 913-921 ◽  
Author(s):  
Hung-Che Shih ◽  
Tzu-Hsin Lee ◽  
Shu-Chen Chen ◽  
Chien-Ying Li ◽  
Takeshi Shibuya
Keyword(s):  
Blood Pressure ◽  
Animal Model ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Renal Hypertension ◽  
Tube Feeding ◽  
Glomerular Sclerosis ◽  
Hypertensive Rats ◽  
Artery Ligation ◽  
Renal Hypertensive Rats

This research investigated the anti-hypertension effect of the traditional Chinese medicine (TCM) Ju-Ling-Tang (JLT) on an animal model of hypertension induced by unilateral renal artery ligation. In the study of anti-hypertension effects, 60 minutes after oral administration with NG tube feeding of 240 mg/kg JLT, a significant decrease in blood pressure ( p < 0.05) was observed and sustained till 120 minutes. In the group given 50 mg/kg α-methyldopa orally, the effect was obvious 90 minutes after medication ( p < 0.01), and lasted until 240 minutes. In terms of organ pathology, a significant reduction in the extent of induced glomerular sclerosis was observed in rats given 240 mg/kg JLT compared with the control. From these results, we infer that JLT has a beneficial anti-hypertensive effect on renal hypertension.

Effect of Cydonia oblonga Mill. fruit and leaf extracts on blood pressure and blood rheology in renal hypertensive rats

2014 ◽  
Vol 152 (3) ◽  
pp. 464-469 ◽  
Author(s):  
Wenting Zhou ◽  
Elzira Abdusalam ◽  
Parida Abliz ◽  
Nadira Reyim ◽  
Shuge Tian ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Rheology ◽  
Hypertensive Rats ◽  
Cydonia Oblonga ◽  
Leaf Extracts ◽  
Renal Hypertensive Rats

Effect of lysergic acid diethylamide and its brom analogue on arterial hypertension in the rat

1961 ◽  
Vol 201 (6) ◽  
pp. 1131-1133 ◽  
Author(s):  
Stephen Sugaar ◽  
George H. Fried ◽  
John Kalberer ◽  
William Antopol
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Subcutaneous Administration ◽  
Absolute Magnitude ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Normal Blood Pressure ◽  
Hypertensive Rats ◽  
Renal Hypertensive Rats ◽  
Normotensive Control

Subcutaneous administration of d-lysergic acid diethylamide (LSD) or 2-brom- d-lysergic acid diethylamide (BOL) markedly lowered the blood pressure of renal hypertensive rats. Drops of 50–120 mm Hg below established hypertensive blood pressure levels occurred within 48 hr after drug administration. For the following 10–14 days the pressure fluctuated, and then returned to original hypertensive levels. In normotensive control rats fluctuations of lesser absolute magnitude occurred within normal blood pressure ranges.

Effect of EXP 3174 on Blood Pressure of Normoreninemic Renal Hypertensive Rats

Hypertension ◽  
1995 ◽  
Vol 25 (2) ◽  
pp. 283-287 ◽  
Author(s):  
Nidia Basso ◽  
María L. Kurnjek ◽  
Patricia Ruiz ◽  
Miguel A. Cannata
Keyword(s):  
Blood Pressure ◽  
Hypertensive Rats ◽  
Renal Hypertensive Rats

Effect of Cydonia oblonga Mill. leaf extracts or captopril on blood pressure and related biomarkers in renal hypertensive rats

2014 ◽  
Vol 153 (3) ◽  
pp. 635-640 ◽  
Author(s):  
Wen-ting Zhou ◽  
Adil Abdurahman ◽  
Elzira Abdusalam ◽  
Wuliya Yiming ◽  
Parida Abliz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Hypertensive Rats ◽  
Cydonia Oblonga ◽  
Leaf Extracts ◽  
Renal Hypertensive Rats
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