ELEVATED PSEUDOCHOLINESTERASE LEVELS IN HYPERTHYROIDISM

Background : Serum Pseudocholinesterase levels are used as an indicator of exposure to various insecticide poisoning. Pseudocholinesterase is a glycoprotein enzyme, produced by liver and circulating in plasma. Pseudocholinesterase plays a role in metabolic degradation of exogenous choline ester drugs. Studies have also shown association of many pathological conditions such as liver disease, obesity, nodular goitre with Pseudocholinesterase levels. The present study was carried out to evaluate the serum Pseudocholinesterase levels in newly diagnosed hypothyroid and hyperthyroid patients. Methodology : A Case control study was done on newly diagnosed hypothyroid and hyperthyroid patients (17 hypothyroid and 17 hyperthyroid patients and 17 healthy volunteers) Results: The age group of the population under study was 20-40 years. The serum levels of TSH in normal, hypothyroid and hyperthyroid groups were 2.5±1.0 uIU/mL, 13±7.3 uIU/mL and 0.22±0.15 uIU/mL. The serum values of Pseudocholinesterase in normal, hypothyroid and hyperthyroid groups were 4038±1157U/L, 4663±1376U/L, 13781±1840U/L respectively, Serum Pseudocholinesterase levels showed signicant increase (3.4 times higher than normal) in hyperthyroid group (p<0.0001). We found a signicant negative correlation between serum Pseudocholinesterase levels and TSH levels (Spearman r coefcient = -0.5; p<0.0001) Conclusion: High Serum Pseudocholinesterase levels can be used as an indicator to screen disruption in thyroid activity.

A study of correlation between thyroid disorders and menstrual disorders in reproductive age group

Present study to evaluate and detect thyroid dysfunction and its correlation in patients with a menstrual disorder in the reproductive age group. Research objectives are to study the prevalence of thyroid disorders in relation to menstrual disorders and study the correlation between menstrual irregularities and thyroid dysfunction. Precise assessments of thyroid hormones in serum become achievable easily and accurately with the introduction of new hormographical research techniques. Hypothyroidism diagnosis is advantageous because it typically relieves the patient of all symptoms. Therefore, the assessment of thyroid activity forms an essential component for the evaluation of a female with menorrhagia or otherwise menstrual irregularities. The individuals are rescued from repeated curettage from hysterectomy by early diagnosis of hypothyroidism Objectively measured menstrual blood losses were 35 ml per menstrual cycle (patients in the age group exposures.

Diagnosis and Treatment of Hyperthyroidism in Pregnancy

Thyroid function fluctuates during pregnancy. Thus, assessments of thyroid activity during childbearing years represent an important health metric. Since anti-thyroid drugs are potentially teratogenic, drug dosing and timing should be carefully calculated. Normally, diagnosis and treatment of hyperthyroidism is performed to determine underlying causes (i.e., Graves' disease), to predict disease course and to make appropriate therapeutic decisions. In cases of maternal hyperthyroidism, these same measures also require the insight regarding the relationship between pregnancy and thyroid function, the effects of anti-thyroid drugs on pregnancy outcomes.