:
An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline-
2,5,10(1H)-triones was developed for the first time. The process proceeded via the
three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid
and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)-
one-ring naphthoquinones have been synthesized with good to high yields in refluxing
ethanol as a green reaction medium. This protocol is simple and effective as well as does
not involve the assistance of the catalyst, additive, or hazardous solvents.
The reaction between alkyl isocyanides and substituted-benzylidene Meldrum's acid derivatives in the presence of water produces 4-(alkylamino)-3-aryl-4-oxobutanoic acids in good yields.
Meldrum's acid in organic synthesis. V. Versatile one-pot synthesis of indolepropionic esters via simultaneous condensation of three different carbon components, indole, aldehydes and Meldrum's acid.