An Expeditious One-Pot Three-Component Synthesis of 4-Aryl-3,4-dihydrobenzo[g] quinoline-2,5,10(1H)-triones under Green Conditions

2020 ◽  
Vol 23 (23) ◽  
pp. 2626-2634
Author(s):  
Saiedeh Kamalifar ◽  
Hamzeh Kiyani
Keyword(s):  
Reaction Medium ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
First Time ◽  
Green Conditions

: An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline- 2,5,10(1H)-triones was developed for the first time. The process proceeded via the three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)- one-ring naphthoquinones have been synthesized with good to high yields in refluxing ethanol as a green reaction medium. This protocol is simple and effective as well as does not involve the assistance of the catalyst, additive, or hazardous solvents.

One-pot atom-efficient synthesis of bio-renewable polyesters and cyclic carbonates through tandem catalysis

2015 ◽  
Vol 51 (40) ◽  
pp. 8504-8507 ◽  
Author(s):  
Fan Jia ◽  
Xiaoyu Chen ◽  
Yan Zheng ◽  
Yusheng Qin ◽  
Youhua Tao ◽  
...  
Keyword(s):  
Tandem Reaction ◽  
Cyclic Carbonates ◽  
Tandem Catalysis ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Salen Complexes ◽  
High Yields ◽  
First Time

One-pot synthesis of well-defined bio-renewable polyesters and cyclic carbonates in high yields was successfully realized for the first time by way of a tandem reaction using metal salen complexes as catalysts.

One Pot Synthesis of Monoalkylated and Mixed, Dialkylated Meldrum's Acid Derivatives

2004 ◽  
Vol 34 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Uday V. Desai ◽  
D. M. Pore ◽  
R. B. Mane ◽  
S. B. Solabannavar ◽  
P. P. Wadgaonkar
Keyword(s):  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Meldrum's Acid Derivatives

Meldrum's acid in organic synthesis. 1. A convenient one-pot synthesis of ethyl indolepropionates

1978 ◽  
Vol 19 (20) ◽  
pp. 1759-1762 ◽  
Author(s):  
Yuji Oikawa ◽  
Hitoshi Hirasawa ◽  
Osamu Yonemitsu
Keyword(s):  
Organic Synthesis ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
One Pot Synthesis

Lithium Perchlorate and Lithium Bromide Catalysed Solvent Free One Pot Rapid Synthesis of 3-Carboxycoumarins under Microwave Irradiation

2002 ◽  
Vol 2002 (1) ◽  
pp. 40-41 ◽  
Author(s):  
B.P. Bandgar ◽  
L.S. Uppalla ◽  
V.S. Sadavarte
Keyword(s):  
Microwave Irradiation ◽  
Lithium Bromide ◽  
Lithium Perchlorate ◽  
Catalytic Amount ◽  
Solvent Free ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Rapid Synthesis ◽  
One Pot ◽  
Substituted Benzaldehydes

Reaction of 2-hydroxy or 2-methoxy substituted benzaldehydes or acetophenones with Meldrum's acid in the presence of a catalytic amount of LiClO4 or LiBr without solvent under microwave irradiation afforded 3-carboxycoumarins in excellent yields.

Cobalt Used as a Novel and Reusable Catalyst: A New and One-Pot Synthesis of Isatin-Derived N,S-Acetals Using Substituted Isatins and Thiols

Synthesis ◽  
2019 ◽  
Vol 51 (21) ◽  
pp. 4014-4022
Author(s):  
Caren D. G. da Silva ◽  
Ramesh Katla ◽  
Beatriz F. dos Santos ◽  
José M. C. Tavares Junior ◽  
Tábata B. Albuquerque ◽  
...  
Keyword(s):  
Heterogeneous Catalyst ◽  
Continuous Flow ◽  
High Conversion ◽  
Reusable Catalyst ◽  
One Pot ◽  
One Pot Synthesis ◽  
High Yields ◽  
Recyclable Heterogeneous Catalyst ◽  
First Time

The synthesis of isatin-derived N,S-acetals using cobalt as a recyclable heterogeneous catalyst in batch and continuous flow is reported for the first time. The present protocol produced high yields, which can be observed from the reaction between ketimines and thiols. Such reactions can also be applied to a gram-scale. In addition, the catalyst is recyclable, economically-viable, and nontoxic as well as easy to prepare. The remarkable features of this new methodology are high conversion and cleaner reaction profiles.

The Reaction of Alkyl Isocyanides and Benzylidene Meldrum's Acid Derivatives in the presence of Water: A One-Pot synthesis of 4-(Alkylamino)-3-Aryl-4-Oxobutanoic Acids

2002 ◽  
Vol 2002 (9) ◽  
pp. 433-435 ◽  
Author(s):  
Ahmad Shaabani ◽  
Mohammad Bagher Teimouri
Keyword(s):  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Alkyl Isocyanides ◽  
Meldrum's Acid Derivatives

The reaction between alkyl isocyanides and substituted-benzylidene Meldrum's acid derivatives in the presence of water produces 4-(alkylamino)-3-aryl-4-oxobutanoic acids in good yields.

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