Stimulation of rat liver growth by a single administration of lead nitrate

1982 ◽  
Vol 65 (3) ◽  
pp. 478-480 ◽  
Author(s):  
G.M. Ledda ◽  
A. Columbano ◽  
T. Perra ◽  
P. Pani
Keyword(s):  
Rat Liver ◽  
Lead Nitrate ◽  
Single Administration ◽  
Liver Growth ◽  
Stimulation Of

STIMULATION OF DNA SYNTHESIS IN RAT LIVER BY ADRENALECTOMY

1974 ◽  
Vol 60 (2) ◽  
pp. 315-319 ◽  
Author(s):  
LUCIA DESSER-WIEST
Keyword(s):  
Dna Synthesis ◽  
Mitotic Index ◽  
Rat Liver ◽  
Normal Level ◽  
Thymidine Incorporation ◽  
Male Rats ◽  
Liver Growth ◽  
Subsequent Administration ◽  
Stimulation Of

SUMMARY The following effects were observed in the liver of male rats in the first few days after adrenalectomy: the rate of thymidine incorporation into DNA was increased three- to fourfold in the 2 days after adrenalectomy. The mitotic index was increased 5·5-fold on the first day and 15-fold on the second day after the operation. The number of tetraploid cells rose from 40 to 68%. While the subsequent administration of cortisol, cortisone or corticosterone to the adrenalectomized animals reduced DNA synthesis to the normal level, testosterone and oestrone were without effect. It is suggested that liver growth is regulated by the concentration of corticosteroids in the blood.

scholarly journals Stimulation of Rat Liver Growth by a 1,3-Dithiole Derivative, KZ-1026

1989 ◽  
Vol 50 (2) ◽  
pp. 101-110
Author(s):  
Yukio HIRAYAMA ◽  
Sonoko TSUCHIDA ◽  
Ritsuko KURATA ◽  
Yumiko KATSUTA ◽  
Kaoru MATSUSHIMA ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Growth ◽  
Stimulation Of

scholarly journals Stimulation of rat liver growth by a 1,3-dithiole derivative, KZ-1026.

1989 ◽  
Vol 50 (2) ◽  
pp. 101-110
Author(s):  
Yukio HIRAYAMA ◽  
Sonoko TSUCHIDA ◽  
Ritsuko KURATA ◽  
Yumiko KATSUTA ◽  
Kaoru MATSUSHIMA ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Growth ◽  
Stimulation Of

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

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