Differential effects of aging on binding sites of the activated NMDA receptor complex in mice

1995 ◽  
Vol 84 (3) ◽  
pp. 227-243 ◽  
Author(s):  
Kathy R. Magnusson
Keyword(s):  
Nmda Receptor ◽  
Binding Sites ◽  
Receptor Complex ◽  
Differential Effects ◽  
Nmda Receptor Complex ◽  
Effects Of Aging

[3H]spermidine binding sites within the NMDA receptor complex in rat brain

1990 ◽  
Vol 183 (5) ◽  
pp. 1664-1665 ◽  
Author(s):  
Y. Yoneda ◽  
K. Ogita ◽  
T. Suzuki ◽  
R. Enomoto
Keyword(s):  
Nmda Receptor ◽  
Rat Brain ◽  
Binding Sites ◽  
Receptor Complex ◽  
Nmda Receptor Complex

Differential effects of β-amyloid peptides on radioligand binding to the NMDA receptor complex

1994 ◽  
Vol 15 ◽  
pp. S18
Author(s):  
Richard F. Cowburn ◽  
Ewa Trief ◽  
Erik Messamore ◽  
Mo Li Li ◽  
Bengt Winblad ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Radioligand Binding ◽  
Receptor Complex ◽  
Amyloid Peptides ◽  
Differential Effects ◽  
Nmda Receptor Complex ◽  
Β Amyloid

scholarly journals Influence of age on NMDA receptor complex in rat brain studied by in vitro autoradiography.

1990 ◽  
Vol 38 (12) ◽  
pp. 1725-1731 ◽  
Author(s):  
S Kito ◽  
R Miyoshi ◽  
T Nomoto
Keyword(s):  
Cerebral Cortex ◽  
Nmda Receptor ◽  
Rat Brain ◽  
Binding Sites ◽  
Recognition Site ◽  
Receptor Complex ◽  
In Vitro Autoradiography ◽  
Aged Brain ◽  
Nmda Receptor Complex

N-methyl-D-aspartate (NMDA) receptors are known to play an important role in learning and memory and to be involved in neuron cell death accompanying cerebral ischemia, seizures, and Alzheimer's disease. The NMDA receptor complex has been considered to consist of an L-glutamate recognition site, a strychnine-insensitive glycine modulatory site, and a voltage-dependent cation channel. In the present study, effects of age on an L-glutamate recognition site and a glycine site were examined in rat brain by quantitative in vitro autoradiography with [3H]-CPP and [3H]-glycine. Both [3H]-glycine and [3H]-CPP binding sites were most abundant in the hippocampus and cerebral cortex, and they showed a similar distribution pattern throughout the brain. [3H]-glycine binding sites were severely decreased in the telencephalic regions, including the hippocampus and cerebral cortex, in aged brain. Conversely, [3H]-CPP binding sites were well preserved in these brain areas. In the mid-brain regions and cerebellum, neither [3H]-glycine nor [3H]-CPP binding sites changed in the aged brain. Our results indicate that within the NMDA receptor complex, glycine receptors are primarily affected in the aging process.

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