Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dimutase-implication for gene dosage effects in down syndrome

Cell ◽  
1988 ◽  
Vol 52 (2) ◽  
pp. 259-267 ◽  
Author(s):  
Orna Elroy-Stein ◽  
Yoram Groner
Keyword(s):  
Down Syndrome ◽  
Pc12 Cells ◽  
Gene Dosage ◽  
Neurotransmitter Uptake ◽  
Gene Dosage Effects ◽  
Dosage Effects ◽  
Superoxide Dimutase

scholarly journals Genetics advances and learning disability

2000 ◽  
Vol 176 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Walter J. Muir
Keyword(s):  
Learning Disability ◽  
Gene Dosage ◽  
Genetic Disorders ◽  
Molecular Medicine ◽  
Gene Dosage Effects ◽  
Dosage Effects ◽  
Rapid Changes ◽  
Basic Understanding ◽  
Genetic Mechanisms ◽  
Dynamic Mutations

BackgroundMedicine is rapidly becoming molecular medicine, and little escapes the grasp of modern genetics. Most disorders associated with learning disability have at least a genetic component influencing their expression; in many disorders, disturbances of genetic mechanisms play a pivotal role.AimsDynamic mutations, imprinting mechanisms and gene-dosage effects are explained with reference to genetic disorders that lead to learning disability.MethodA review of recent important studies in the genetics of learning disability.ResultsA host of new genetic connections to conditions associated with learning disability have been made.ConclusionsA basic understanding of these genetic connections is important for all learning disability psychiatrists if they are to follow the rapid changes – already beginning to influence our practice – that hold immense promise for the future.

Gene Dosage Effects at the ae Locus on Amylose Content of Corn Endosperm

1966 ◽  
Vol 57 (3) ◽  
pp. 90-90 ◽  
Author(s):  
V. L. FERG ASON ◽  
J. L. HELM ◽  
M. S. ZUBER
Keyword(s):  
Gene Dosage ◽  
Amylose Content ◽  
Gene Dosage Effects ◽  
Dosage Effects

Gene Dosage Effects on Corn Endosperm Carbohydrates 1

1953 ◽  
Vol 45 (3) ◽  
pp. 101-104 ◽  
Author(s):  
G. M. Dunn ◽  
H. H. Kramer ◽  
Roy L. Whistler
Keyword(s):  
Gene Dosage ◽  
Gene Dosage Effects ◽  
Dosage Effects
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