Endothelial cell expression of the intercellular adhesion molecule-1 (ICAM-1) in the central nervous system of guinea pigs during acute and chronic relapsing experimental allergic encephalomyelitis

1990 ◽  
Vol 30 (1) ◽  
pp. 43-51 ◽  
Author(s):  
C.E. Wilcox ◽  
A.M.V. Ward ◽  
A. Evans ◽  
D. Baker ◽  
R. Rothlein ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Intercellular Adhesion Molecule ◽  
Allergic Encephalomyelitis ◽  
Intercellular Adhesion Molecule 1 ◽  
The Central Nervous System ◽  
Cell Expression ◽  
Experimental Allergic

Endothelial Cell Expression of Intercellular Adhesion Molecule 1 in Experimental Posthemorrhagic Vasospasm

Neurosurgery ◽  
1997 ◽  
Vol 41 (2) ◽  
pp. 453-461 ◽  
Author(s):  
Allen K. Sills ◽  
Richard E. Clatterbuck ◽  
Thompson Reid C. ◽  
Paul L. Cohen ◽  
Tamargo Rafael J.
Keyword(s):  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Cell Expression

scholarly journals Upregulation and coexpression of adhesion molecules correlate with relapsing autoimmune demyelination in the central nervous system.

1990 ◽  
Vol 172 (5) ◽  
pp. 1521-1524 ◽  
Author(s):  
B Cannella ◽  
A H Cross ◽  
C S Raine
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adhesion Molecules ◽  
Cell Invasion ◽  
Inflammatory Cell ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Murine Homologue ◽  
The Central Nervous System ◽  
Autoimmune Demyelination

The expression of adhesion molecules on central nervous system (CNS) vessels was examined during chronic relapsing experimental autoimmune encephalomyelitis in the SJL mouse. Two molecules associated with cell adhesion were studied: MECA-325, a murine lymph node high endothelial venule marker; and MALA-2, the murine homologue of intercellular adhesion molecule 1. During initial disease, upregulated coexpression of these two molecules occurred in the CNS. This correlated with inflammatory cell invasion. During remission, expression was downregulated, and each subsequent relapse was accompanied by corresponding upregulation. Thus, up- and downregulation of adhesion molecules in the target organ appeared to form an integral part of the inflammatory process in this autoimmune condition and support a role for receptor-mediated inflammatory cell invasion of relevance to the pathogenesis of multiple sclerosis.

Sign in / Sign up

Export Citation Format

Share Document