Theoretical studies of α-acetylenic alcohols rearrangement mechanism: Ab initio calculations of the unimolecular rate limiting step

1986 ◽  
Vol 138 (1-2) ◽  
pp. 171-177 ◽  
Author(s):  
J. Andrés ◽  
E. Silla ◽  
O. Tapia
Keyword(s):  
Ab Initio Calculations ◽  
Ab Initio ◽  
Theoretical Studies ◽  
Rate Limiting Step ◽  
Limiting Step ◽  
Rearrangement Mechanism ◽  
Rate Limiting

scholarly journals Insight into wild-type and T1372E TET2-mediated 5hmC oxidation using ab initio QM/MM calculations

2018 ◽  
Vol 9 (44) ◽  
pp. 8433-8445 ◽  
Author(s):  
Hedieh Torabifard ◽  
G. Andrés Cisneros
Keyword(s):  
Ab Initio ◽  
Wild Type ◽  
Rate Limiting Step ◽  
Limiting Step ◽  
Rate Limiting ◽  
Insight Into

T1372E TET2 stalls at 5hmC due to unfavorable orientation of substrate, which increases barrier of the rate limiting step.

Ornithine Decarboxylase Activity in Cultured Endothelial Cells Stimulated by Serum, Thrombin and Serotonin

1978 ◽  
Vol 39 (02) ◽  
pp. 496-503 ◽  
Author(s):  
P A D’Amore ◽  
H B Hechtman ◽  
D Shepro
Keyword(s):  
Endothelial Cells ◽  
Ornithine Decarboxylase ◽  
Decarboxylase Activity ◽  
Aortic Endothelial Cells ◽  
Ornithine Decarboxylase Activity ◽  
Rate Limiting Step ◽  
Bovine Aortic Endothelial Cells ◽  
Limiting Step ◽  
Rate Limiting ◽  
Serum Serotonin

SummaryOrnithine decarboxylase (ODC) activity, the rate-limiting step in the synthesis of polyamines, can be demonstrated in cultured, bovine, aortic endothelial cells (EC). Serum, serotonin and thrombin produce a rise in ODC activity. The serotonin-induced ODC activity is significantly blocked by imipramine (10-5 M) or Lilly 11 0140 (10-6M). Preincubation of EC with these blockers together almost completely depresses the 5-HT-stimulated ODC activity. These observations suggest a manner by which platelets may maintain EC structural and metabolic soundness.

Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo

Diabetes ◽  
1993 ◽  
Vol 42 (2) ◽  
pp. 296-306 ◽  
Author(s):  
D. C. Bradley ◽  
R. A. Poulin ◽  
R. N. Bergman
Keyword(s):  
Rate Limiting Step ◽  
Limiting Step ◽  
Rate Limiting
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