Differential blocking action of Joro spider toxin analog on parallel fiber and climbing fiber synapses in cerebellar Purkinje cells

1991 ◽  
Vol 12 (1) ◽  
pp. 281-286 ◽  
Author(s):  
Ayako Ajima ◽  
Takao Hensch ◽  
Raymond T. Kado ◽  
Masao Ito
Keyword(s):  
Purkinje Cells ◽  
Climbing Fiber ◽  
Parallel Fiber ◽  
Spider Toxin ◽  
Cerebellar Purkinje Cells ◽  
Differential Blocking

scholarly journals Regulation of Long-Term Depression and Climbing Fiber Territory by Glutamate Receptor  2 at Parallel Fiber Synapses through its C-Terminal Domain in Cerebellar Purkinje Cells

2007 ◽  
Vol 27 (44) ◽  
pp. 12096-12108 ◽  
Author(s):  
T. Uemura ◽  
S. Kakizawa ◽  
M. Yamasaki ◽  
K. Sakimura ◽  
M. Watanabe ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Glutamate Receptor ◽  
Climbing Fiber ◽  
Parallel Fiber ◽  
Long Term Depression ◽  
Terminal Domain ◽  
Cerebellar Purkinje Cells

scholarly journals Cav3-KCa3.1 complex enhances detection of facilitating parallel fiber inputs in cerebellar Purkinje cells

2012 ◽  
Vol 13 (S1) ◽  
Author(s):  
Jordan DT Engbers ◽  
Ray W Turner
Keyword(s):  
Purkinje Cells ◽  
Parallel Fiber ◽  
Cerebellar Purkinje Cells

scholarly journals Reciprocal Bidirectional Plasticity of Parallel Fiber Receptive Fields in Cerebellar Purkinje Cells and Their Afferent Interneurons

Neuron ◽  
2002 ◽  
Vol 34 (5) ◽  
pp. 797-806 ◽  
Author(s):  
Henrik Jörntell ◽  
Carl-Fredrik Ekerot
Keyword(s):  
Purkinje Cells ◽  
Receptive Fields ◽  
Parallel Fiber ◽  
Cerebellar Purkinje Cells

Normal adult climbing fiber monoinnervation of cerebellar Purkinje cells in mice lacking MHC class I molecules

2008 ◽  
Vol 68 (8) ◽  
pp. 997-1006 ◽  
Author(s):  
Mathieu Letellier ◽  
Melina L. Willson ◽  
Vanessa Gautheron ◽  
Jean Mariani ◽  
Ann M. Lohof
Keyword(s):  
Purkinje Cells ◽  
Mhc Class I ◽  
Climbing Fiber ◽  
Class I ◽  
Normal Adult ◽  
Cerebellar Purkinje Cells ◽  
Mhc Class I Molecules

scholarly journals Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells

2019 ◽  
Vol 22 (6) ◽  
pp. 950-962 ◽  
Author(s):  
Dimitar Kostadinov ◽  
Maxime Beau ◽  
Marta Blanco-Pozo ◽  
Michael Häusser
Keyword(s):  
Purkinje Cells ◽  
Climbing Fiber ◽  
Cerebellar Purkinje Cells

Climbing fiber action on the responsiveness of Purkinje cells to parallel fiber inputs

1984 ◽  
Vol 309 (1) ◽  
pp. 182-186 ◽  
Author(s):  
Timothy J. Ebner ◽  
James R. Bloedel
Keyword(s):  
Purkinje Cells ◽  
Climbing Fiber ◽  
Parallel Fiber ◽  
Fiber Action

Postsynaptic Current Mediated by Metabotropic Glutamate Receptors in Cerebellar Purkinje Cells

1998 ◽  
Vol 80 (2) ◽  
pp. 520-528 ◽  
Author(s):  
Filippo Tempia ◽  
Maria Concetta Miniaci ◽  
Davide Anchisi ◽  
Piergiorgio Strata
Keyword(s):  
Glutamate Receptors ◽  
Purkinje Cells ◽  
Metabotropic Glutamate Receptors ◽  
Parallel Fiber ◽  
High Concentration ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Cerebellar Purkinje Cells ◽  
Mglur Antagonist ◽  
Fiber Stimulation

Tempia, Filippo, Maria Concetta Miniaci, Davide Anchisi, and Piergiorgio Strata. Postsynaptic current mediated by metabotropic glutamate receptors in cerebellar Purkinje cells. J. Neurophysiol. 80: 520–528, 1998. In rat cerebellar slices, repetitive parallel fiber stimulation evokes an inward, postsynaptic current in Purkinje cells with a fast component mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and a slower component mediated by metabotropic glutamate receptors (mGluR). The mGluR-mediated excitatory postsynaptic current (mGluR-EPSC) is evoked selectively by parallel fiber stimulation; climbing fiber stimulation is ineffective. The mGluR-EPSC is elicited most effectively with increasing frequencies of parallel fiber stimulation, from a threshold of 10 Hz to a maximum response at ∼100 Hz. The amplitude of the mGluR-EPSC is a linear function of the number of stimulus pulses without any apparent saturation, even with >10 pulses. Thus mGluRs at the parallel fiber-Purkinje cell synapse can function as linear detectors of the number of spikes in a burst of activity in parallel fibers. The mGluR-EPSC is present from postnatal day 15 and persists into adulthood. It is inhibited by the generic mGluR antagonist (RS)-a-methyl-4-carboxyphenylglycine and by the group I mGluR antagonist (RS)-1-aminoindan-1,5-dicarboxylic acid at a concentration selective for mGluR1. Although the intracellular transduction pathway involves a G protein, the putative mediators of mGluR1 (phospholipase C and protein kinase C) are not directly involved, indicating that the mGluR-EPSC studied here is mediated by a different and still unidentified second-messenger pathway. Heparin, a nonselective antagonist of inositol-trisphosphate (IP3) receptors, has no significant effect on the mGluR-EPSC, suggesting that also IP3 might be not required for the response. Buffering intracellular Ca2+ with a high concentration of bis-( o-aminophenoxy)- N,N,N′,N′-tetraacetic acid partially inhibits the mGluR-EPSC, indicating that Ca2+ is not directly responsible for the response but that resting Ca2+ levels exert a tonic potentiating effect on the mGluR-EPSC.

GLAST is essential to maintain climbing fiber monoinnervation and glial synapse enwrapping to cerebellar Purkinje cells

2009 ◽  
Vol 65 ◽  
pp. S44
Author(s):  
Taisuke Miyazaki ◽  
Kohichi Tanaka ◽  
Masahiko Watanabe
Keyword(s):  
Purkinje Cells ◽  
Climbing Fiber ◽  
Cerebellar Purkinje Cells
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