Stimulation of rat parotid gland secretion by cAMP analogues that synergistically activate the type II isoenzyme of the cAMP-dependent protein kinase

1992 ◽  
Vol 50 (11) ◽  
pp. 1249
Author(s):  
M.A. Plant
Keyword(s):  
Protein Kinase ◽  
Parotid Gland ◽  
Gland Secretion ◽  
Type Ii ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Rat Parotid Gland ◽  
Dependent Protein ◽  
Rat Parotid ◽  
Stimulation Of

Effect of NaF on cAMP Accumulation, cAMP-dependent Protein Kinase Activity in, and Amylase Secretion from, Rat Parotid Gland Cells

1988 ◽  
Vol 67 (2) ◽  
pp. 462-466 ◽  
Author(s):  
A.R. Shahed ◽  
D.W. Allmann
Keyword(s):  
Protein Kinase ◽  
Parotid Gland ◽  
Amylase Secretion ◽  
Protein Kinase Activity ◽  
Camp Concentration ◽  
Dependent Protein Kinase ◽  
Gland Cells ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein ◽  
Rat Parotid

Stimulation of amylase secretion from parotid glands by beta-adrenergic agonists is mediated by the activation of adenylate cyclase and the resultant increase in cellular cAMP. Since NaF is known to increase adenylate cyclase activity and cAMP accumulation in intact cells, we investigated whether it would stimulate amylase secretion from isolated rat parotid gland cells. The results provide evidence that the addition of NaF (0.01 - 10 mmol/L) increased cAMP concentration (1.5-2.8-fold) in, and amylase secretion (16-93%) from, isolated parotid gland acinar cells. NaF was found to increase cAMP-dependent protein kinase activity ratios (51-84%) in a concentration-and time-dependent manner. The data suggest that the stimulation of amylase secretion from parotid gland cells by NaF may be mediated by an increase in the cellular cAMP concentration, which exerts its effect, at least in part, by increasing the activity of cAMP-dependent protein kinase.

scholarly journals Properties of the regulatory subunit of cAMP-dependent protein kinase type II from human brain

IUBMB Life ◽  
1996 ◽  
Vol 40 (6) ◽  
pp. 1159-1166
Author(s):  
I. D. Grozdova ◽  
N. A. Alexandrova ◽  
E. V. Sveshnikova ◽  
N. S. Melik-Nubarov ◽  
P. G. Sveshnikov ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Human Brain ◽  
Regulatory Subunit ◽  
Type Ii ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Dependent Protein
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