Characterization of the developmental toxicity of di-n-butyl phthalate in rats

Toxicology ◽  
1994 ◽  
Vol 86 (3) ◽  
pp. 163-174 ◽  
Author(s):  
Makoto Ema ◽  
Hiro Amano ◽  
Yoshiyuki Ogawa
Keyword(s):  
Developmental Toxicity ◽  
Butyl Phthalate

Characterization of developmental toxicity of mono-n-benzyl phthalate in rats

1996 ◽  
Vol 10 (5) ◽  
pp. 365-372 ◽  
Author(s):  
Makoto Ema ◽  
Akira Harazono ◽  
Emiko Miyawaki ◽  
Yoshiyuki Ogawa
Keyword(s):  
Developmental Toxicity

NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate

2002 ◽  
Vol 16 (5) ◽  
pp. 489-527 ◽  
Author(s):  
Robert Kavlock ◽  
Kim Boekelheide ◽  
Robert Chapin ◽  
Michael Cunningham ◽  
Elaine Faustman ◽  
...  
Keyword(s):  
Expert Panel ◽  
Developmental Toxicity ◽  
Human Reproduction ◽  
Panel Report ◽  
Butyl Phthalate

scholarly journals Oxidative stress response associates with the teratogenic effects of benzyl butyl phthalate (BBP)

2020 ◽  
Vol 9 (3) ◽  
pp. 222-229
Author(s):  
Ge Song ◽  
Rui Wang ◽  
Yi Cui ◽  
Chan Juan Hao ◽  
Hong-Fei Xia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Neural Tube ◽  
Developmental Toxicity ◽  
Animal Experiments ◽  
Environmental Pollutant ◽  
High Dose ◽  
Teratogenic Effects ◽  
Benzyl Butyl Phthalate ◽  
Detection Ratio ◽  
Butyl Phthalate

Abstract Benzyl butyl phthalate (BBP) is a persistent environmental pollutant. BBP exposure and the possible effects on human neural tube defects (NTDs) remain elusive. In this study, we found that the detection ratio of positive BBP and its metabolites in maternal urine was obviously higher in NTDs’ population than that in normal controls by GC-MS (P < 0.01, P < 0.05, respectively). Animal experiments showed that BBP treatment induced developmental toxicity in chick embryo by enhancing the levels of oxidative stress and cell apoptosis (P < 0.01). More interestingly, the supplement of high-dose choline (CHO, 10 5 μg/mL) could partially restore the teratogenic effects of BBP by inhibiting the occurrence of oxidative stress. Our data collectively suggest that BBP exposure may disturb neural tube development by strengthening oxidative stress. CHO can partially restore the toxicity effects of BBP. This study may provide new insight for NTD prevention.

scholarly journals Characterization of a developmental toxicity dose-response model.

1989 ◽  
Vol 79 ◽  
pp. 229-241 ◽  
Author(s):  
E M Faustman ◽  
D G Wellington ◽  
W P Smith ◽  
C A Kimmel
Keyword(s):  
Dose Response ◽  
Developmental Toxicity ◽  
Response Model

Developmental toxicity evaluation of mono-n-butyl phthalate in rats

1995 ◽  
Vol 78 (2) ◽  
pp. 101-106 ◽  
Author(s):  
Makoto Ema ◽  
Reiko Kurosaka ◽  
Hiro Amano ◽  
Yoshiyuki Ogawa
Keyword(s):  
Developmental Toxicity ◽  
Toxicity Evaluation ◽  
Butyl Phthalate
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