The role of the endothelium on enhanced contractile response of non-insulin-dependent diabetic rat aortae: Effects of insulin treatment

1994 ◽  
Vol 25 (4) ◽  
pp. 795-802 ◽  
Author(s):  
Çimen Karasu ◽  
V.Melih Altan
Keyword(s):  
Insulin Treatment ◽  
Contractile Response ◽  
Diabetic Rat ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Intensified treatment of pregnant insulin-dependent diabetic women

1986 ◽  
Vol 113 (3_Suppl) ◽  
pp. S77-S80 ◽  
Author(s):  
L. Jovanovic ◽  
C. M. Peterson
Keyword(s):  
Insulin Treatment ◽  
Standard Of Care ◽  
Treatment Programs ◽  
Insulin Dependent ◽  
Intensified Insulin Treatment ◽  
Insulin Dependent Diabetic

Abstract. Intensified treatment of glycaemic excurtions has become the standard of care for all insulindependent diabetic women. This paper reviews the rationale for intensified insulin treatment programs and offers the algorithms of one approach to achieve and maintain normoglycaemia throughout pregnancy.

Nitric oxide mediates increased prostaglandin E production by oocyte - cumulus complexes in the non-insulin-dependent diabetic rat

1998 ◽  
Vol 10 (2) ◽  
pp. 185 ◽  
Author(s):  
Alicia Jawerbaum ◽  
Elida T. Gonzalez ◽  
Virginia Novaro ◽  
Alicia Faletti ◽  
Martha A. F. Gimeno
Keyword(s):  
Nitric Oxide ◽  
Diabetic Rats ◽  
No Synthase ◽  
Diabetic Rat ◽  
Prostaglandin E ◽  
Basal Secretion ◽  
No Donors ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Synthase Inhibitor

Previous work described an increase in prostaglandin E (PGE) production by oocyte–cumulus complexes (OVA) obtained from non-insulin-dependent diabetic rats. More recently, it has been found that in control OVA nitric oxide (NO) mediates hCG-induced PGE secretion. To determine whether increases in PGE secretion by diabetic OVA are mediated by NO, the present study has evaluated the secretion of PGE by diabetic OVA, cultured in the absence or presence of hCG, NO donors (sodium nitroprusside (NP) and 3-morpholino-sydnonimine-hydrochloride (SIN–1)), and a NO synthase inhibitor (NG monomethyl-L-arginine; L-NMMA). hCG, NP and SIN–1 increased PGE secretion by diabetic OVA. L-NMMA did not modify basal secretion of PGE by control OVA but lowered PGE production in diabetic OVA to control values. L-NMMA prevented the hCG-induced PGE accumulation in control and diabetic OVA, and the quantities of PGE produced were similar to those of control OVA but lower than in diabetic OVA incubated in the absence of hCG. The effect of L-NMMA seems to be specific since NG monomethyl-D-arginine had no effect. NO synthase activity was higher in diabetic ovaries than in controls. The present results suggest that NO mediates the increased PGE production by diabetic OVA, probably a result of overproduction of NO.

scholarly journals Insulin treatment of the insulin-dependent diabetic patient undergoing minor surgery.

Anaesthesia ◽  
1988 ◽  
Vol 43 (7) ◽  
pp. 533-537 ◽  
Author(s):  
C. L. CHRISTIANSEN ◽  
B. A. SCHURIZEK ◽  
B. MALLING ◽  
L. KNUDSEN ◽  
K. G. M. M. ALBERTI ◽  
...  
Keyword(s):  
Diabetic Patient ◽  
Insulin Treatment ◽  
Minor Surgery ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Role of smoking and HbA1c level in periodontitis among insulin-dependent diabetic patients

2003 ◽  
Vol 30 (10) ◽  
pp. 871-875 ◽  
Author(s):  
Anna-Maija H. Syrjälä ◽  
Pekka Ylöstalo ◽  
Mirka C. Niskanen ◽  
Matti L. E. Knuuttila
Keyword(s):  
Hba1c Level ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Protein C Deficiency in Insulin-Dependent Diabetes: A Hyperglycemia-Related Phenomenon

1990 ◽  
Vol 64 (01) ◽  
pp. 104-107 ◽  
Author(s):  
Antonio Ceriello ◽  
Antonio Quatraro ◽  
Patrizia Dello Russo ◽  
Egidio Marchi ◽  
Miriam Barbanti ◽  
...  
Keyword(s):  
Protein C ◽  
Insulin Infusion ◽  
Inverse Correlation ◽  
Normal Subjects ◽  
Diabetic Patients ◽  
Related Phenomenon ◽  
Protein C Deficiency ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

SummaryIn 30 insulin-dependent diabetic patients protein C (PC) antigen and PC activity were significantly lower than those of matched control healthy subjects. An inverse correlation between fasting plasma glucose and both PC concentration and activity was present in diabetics, while a direct correlation between PC concentration and PC activity was observed. Induced hyperglycemia in diabetic and normal subjects was able to decrease both PC antigen levels and PC activity, and heparin reversed in part this effect.In diabetic patients euglycemia obtained by insulin infusion restored to normal the depressed PC levels. Heparin did not alter both the basal PC concentration and activity in healthy controls.These data stress the major role of hyperglycemia in determining PC decrease in diabetics, and suggest that PC reduction is probably associated to hyperglycemia-enhanced thrombin formation.

Sign in / Sign up

Export Citation Format

Share Document