The alpha (α) elastic scattering from different targets potential over the energy range 10–240 MeV has been analyzed in the framework of the single-folding (SF) optical model. Four targets are considered, namely, 24 Mg , 28 Si , 32 S and 40 Ca . The SF calculations for the real central part of the nuclear optical potential are performed by folding an effective α–α interaction with the α-cluster distribution density in the target nucleus. The imaginary part of the optical potential is expressed in the phenomenological Woods–Saxon (WS) form. The calculated angular distributions of the elastic scattering differential cross-section using the derived semimicroscopic potentials successfully reproduce 36 sets of data all over the measured angular ranges. The obtained results confirm the validity of the α-cluster structure of the considered nuclei. For the sake of comparison, the same sets of data are reanalyzed using microscopic double-folded optical potentials based upon the density-dependent Jeukenne–Lejeune–Mahaux (JLM) effective nucleon–nucleon interaction.