In vitro activity of DNA gyrase inhibitors, singly and in combination, against Mycobacterium avium complex

1992 ◽  
Vol 15 (4) ◽  
pp. 367-370 ◽  
Author(s):  
Timothy J. Babinchak ◽  
Robert J. Fass
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Dna Gyrase ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Gyrase Inhibitors

scholarly journals Enhanced in vitro activity of WR99210 in combination with dapsone against Mycobacterium avium complex.

1996 ◽  
Vol 40 (11) ◽  
pp. 2644-2645 ◽  
Author(s):  
L M Shah ◽  
M S DeStefano ◽  
M H Cynamon
Keyword(s):  
Dihydrofolate Reductase ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Reductase Inhibitor ◽  
Vitro Activity ◽  
Dilution Method ◽  
In Vitro Activity ◽  
Fixed Concentration ◽  
Broth Dilution

WR99210, a dihydrofolate reductase inhibitor, has promising in vitro activity against Mycobacterium avium complex (MAC). The in vitro activities of WR99210 alone and in combination with a fixed concentration of dapsone (0.5 microgram/ml) were evaluated against 35 clinical MAC isolates by a broth dilution method. The MIC at which 50% of isolates were inhibited (MIC50) and MIC90 of WR99210 alone were 2 and 8 micrograms/ml, respectively. The MIC50 and MIC90 of WR99210 in combination with dapsone were 0.25 and 4 micrograms/ml, respectively. Overall, 75% of the MAC isolates displayed enhanced susceptibility to the combination.

In-vitro activity of oxazolidinones against Mycobacterium avium Complex

1995 ◽  
Vol 35 (5) ◽  
pp. 675-679 ◽  
Author(s):  
Julius Peters ◽  
Kimi L. Kondo ◽  
Richard K. Lee ◽  
Carol K. Lin ◽  
Clark B. Inderlied
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Vitro Activity ◽  
In Vitro Activity

Structure based drug discovery and in vitro activity testing for DNA gyrase inhibitors of Salmonella enterica serovar Typhi

2020 ◽  
Vol 104 ◽  
pp. 104244
Author(s):  
Priyanka Sharma ◽  
Manoj Kumar ◽  
Sushila Dahiya ◽  
Seema Sood ◽  
Bimal Kumar Das ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Salmonella Enterica ◽  
Dna Gyrase ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Salmonella Enterica Serovar Typhi ◽  
Gyrase Inhibitors

scholarly journals Enhanced in vitro activity of pyrimethamine in combination with dapsone against Mycobacterium avium complex.

1996 ◽  
Vol 40 (10) ◽  
pp. 2426-2427 ◽  
Author(s):  
L M Shah ◽  
S C Meyer ◽  
M H Cynamon
Keyword(s):  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Vitro Activity ◽  
Clinical Isolates ◽  
In Vitro Activity ◽  
Enhanced Activity ◽  
Fixed Concentration ◽  
Broth Dilution

The in vitro activities of pyrimethamine and dapsone alone and in combination were evaluated against 23 clinical isolates of Mycobacterium avium complex. The broth dilution MICs of dapsone and pyrimethamine alone ranged from 16 to > 64 micrograms/ml. Pyrimethamine in combination with a fixed concentration of dapsone at 0.5 microgram/ml showed enhanced activity, with an MIC range of 0.5 to 16 micrograms/ml.

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