Neuropsychological correlates of Single Photon Emission Tomography (SPECT) in Alzheimer's disease

1989 ◽  
Vol 4 (2) ◽  
pp. 117
Author(s):  
F Schmitt
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Photon ◽  
Photon Emission ◽  
Single Photon Emission Tomography ◽  
Emission Tomography ◽  
Single Photon Emission ◽  
Neuropsychological Correlates ◽  
Photon Emission Tomography

The pattern of function-related regional cerebral blood flow investigated by single photon emission tomography with99mTc-HMPAO in patients with presenile Alzheimer's disease and Korsakoff's psychosis

1989 ◽  
Vol 19 (4) ◽  
pp. 847-855 ◽  
Author(s):  
R. Hunter ◽  
R. McLuskie ◽  
D. Wyper ◽  
J. Patterson ◽  
J. E. Christie ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Regional Cerebral Blood ◽  
Single Photon Emission ◽  
Cortical Areas ◽  
Photon Emission Tomography

SYNOPSISSingle photon emission tomography (SPET) with the lipophilic blood flow marker99mTc-hexamethyl propyleneamine oxime (99mTc-HMPAO) has been used to determine regional uptake of radiolabel into brain regions of patients with presenile Alzheimer's disease and Korsakoff's psychosis, and age-matched controls. Using occipital cortical uptake as reference area, the pattern of relative regional cerebral blood flow (rCBF) was determined in other cortical areas and basal ganglia. In Alzheimer's disease, reduction in rCBF occurred most strikingly in posterior temporal and parietal areas. By contrast, in Korsakoff's psychosis, posterior temporal rCBF was maintained, although there was a trend to reduced tracer uptake in other cortical areas. These impairments of flow were correlated with impairments of neuropsychological function. In Alzheimer's disease, left posterior temporal and left parietal regions in particular showed rCBF to be strongly correlated with most aspects of cognitive function. In Korsakoff's psychosis, however, impaired flow in frontal regions was correlated with impaired performance on tests of memory and orientation. The findings in Alzheimer's disease show quantitative parallels with those from studies using Positron Emission Tomography (PET), and extend our understanding of the relationship between cognition and regional brain function in dementia. The findings in Korsakoff's psychosis offer the first direct evidence linking frontal lobe dysfunction with the cognitive impairment seen in the disorder.

Early prediction of donepezil cognitive response in Alzheimer’s disease by brain perfusion single photon emission tomography

2019 ◽  
Vol 13 (6) ◽  
pp. 1665-1673
Author(s):  
Supatporn Tepmongkol ◽  
Solaphat Hemrungrojn ◽  
Patrick Dupont ◽  
Chavit Tunvirachaisakul ◽  
Daruj Aniwattanapong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Single Photon ◽  
Photon Emission ◽  
Brain Perfusion ◽  
Single Photon Emission Tomography ◽  
Emission Tomography ◽  
Early Prediction ◽  
Single Photon Emission ◽  
Cognitive Response ◽  
Photon Emission Tomography
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