Effects of photodynamic therapy with topical application of 5-aminolevulinic acid on normal skin of hairless guinea pigs

1992 ◽  
Vol 15 (3) ◽  
pp. 239-251 ◽  
Author(s):  
Barbara A. Goff ◽  
Rüdiger Bachor ◽  
Nikiforos Kollias ◽  
Tayyaba Hasan
Keyword(s):  
Photodynamic Therapy ◽  
Topical Application ◽  
Guinea Pigs ◽  
Aminolevulinic Acid ◽  
Normal Skin ◽  
Hairless Guinea Pigs

Photodynamic Therapy of Cutaneous Lymphoma Using 5-Aminolevulinic Acid Topical Application

2000 ◽  
Vol 26 (8) ◽  
pp. 765-770 ◽  
Author(s):  
Arie Orenstein ◽  
Joseph Haik ◽  
Jeremy Tamir ◽  
Eyal Winkler ◽  
Henry Trau ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Topical Application ◽  
Aminolevulinic Acid ◽  
Cutaneous Lymphoma

Topical Application of 5-Aminolevulinic Acid Is Sufficient for Photodynamic Therapy on Vocal Folds

2018 ◽  
Vol 129 (2) ◽  
pp. E80-E86
Author(s):  
Chi Zhang ◽  
Ting Gong ◽  
Jiajia Wang ◽  
Adriana Chou ◽  
Jack J. Jiang
Keyword(s):  
Photodynamic Therapy ◽  
Topical Application ◽  
Aminolevulinic Acid ◽  
Vocal Folds

Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified δ-aminolevulinic acid

2001 ◽  
Vol 05 (02) ◽  
pp. 147-153 ◽  
Author(s):  
MARCELO SOTO THOMPSON ◽  
LOTTA GUSTAFSSON ◽  
SARA PÅLSSON ◽  
NIELS BENDSOE ◽  
MARIA STENBERG ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Basal Cell ◽  
Aminolevulinic Acid ◽  
Normal Skin ◽  
Continuous Light ◽  
Blood Perfusion ◽  
Surrounding Tissue ◽  
Ir Camera ◽  
Fluorescence Measurements ◽  
Basal Cell Carcinomas

Various optical techniques were used to investigate relevant parameters involved in photodynamic therapy (PDT) of human basal cell carcinomas (BCCs). The aim of the study was to compare the diagnostic and therapeutic outcome when using topically applied methyl-esterified δ-aminolevulinic acid (ALA-ME) and δ-aminolevulinic acid (ALA). A total of 35 pathologically verified BCCs in 14 patients were investigated. A diode laser, emitting continuous light at 633 nm, was used to induce PDT. The diagnostic measurements were performed before, during, and after PDT. Laser-induced fluorescence (LIF) was used to monitor the build-up of the ALA/ALA-ME-induced protoporphyrin IX ( PpIX ). The superficial tissue perfusion was measured with laser-Doppler perfusion imaging (LDPI) and the temperature of the lesion and the surrounding tissue was imaged with an IR-camera. A clear demarcation between the lesion and the normal skin was detected with LIF before the treatment for both PpIX precursors. The fluorescence measurements suggest that PpIX builds up to a higher degree and more selectively in the tumour following ALA-ME as compared to ALA. The LDPI measurements indicate a local transient restriction in blood perfusion immediately post-PDT. The measurement with the IR-camera revealed a temperature rise of about 1–2 °C during the treatment.

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