In vivo effects of the anesthetic, benzocaine, on liver microsomal cytochrome P450 and mixed-function oxidase activities of gilthead seabream (Sparus aurata)

1994 ◽  
Vol 107 (3) ◽  
pp. 399-404 ◽  
Author(s):  
E. Arinç ◽  
A. Şen
Keyword(s):  
Cytochrome P450 ◽  
Sparus Aurata ◽  
Gilthead Seabream ◽  
Mixed Function Oxidase ◽  
Microsomal Cytochrome ◽  
Microsomal Cytochrome P450 ◽  
In Vivo Effects

scholarly journals In Vivo Effects of Lipopolysaccharide on Peroxisome Proliferator-Activated Receptor Expression in Juvenile Gilthead Seabream (Sparus Aurata)

Biology ◽  
2017 ◽  
Vol 6 (4) ◽  
pp. 36 ◽  
Author(s):  
Efthimia Antonopoulou ◽  
Elisavet Kaitetzidou ◽  
Barbara Castellana ◽  
Nikolas Panteli ◽  
Dimitrios Kyriakis ◽  
...  
Keyword(s):  
Sparus Aurata ◽  
Receptor Expression ◽  
Gilthead Seabream ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
In Vivo Effects

scholarly journals In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2- (phosphonomethoxy) propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450

2008 ◽  
pp. 761-768
Author(s):  
E Anzenbacherová ◽  
P Anzenbacher ◽  
Z Zídek ◽  
E Buchar ◽  
E Kmoníčková ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Rat Liver ◽  
Relative Proportion ◽  
Antiviral Agent ◽  
Total Content ◽  
Repeated Administration ◽  
Microsomal Protein ◽  
Microsomal Cytochrome ◽  
Microsomal Cytochrome P450

The total content of rat liver microsomal cytochrome P450 (CYP) significantly decreased after repeated i.p. administration of the antiviral agent tenofovir ((R)-9-[2-(phosphonomethoxy)propyl] adenine) and tenofovir disoproxil at a daily dose 25 mg/kg, although the content of liver microsomal protein did not change. The decrease of the CYP content was accompanied by concomitant increase of the amount of inactive CYP form, cytochrome P420. This effect was confirmed by a parallel study of the activities of selected CYP forms, CYP2E1 (p-nitrophenol hydroxylation) and CYP1A2 (7-ethoxyresorufin deethylation). The activity (expressed relatively to the protein content) of both CYP forms decreased significantly following the decrease of the total CYP. On the other hand, the CYP2E1 activity expressed relatively to the decreasing total CYP content remained unchanged. However, CYP1A2 activity also decreased when calculated relatively to the total native CYP content indicating lower stability of this form. Semiquantitative RT-PCR showed no significant changes in expression of major rat liver microsomal CYP forms after tenofovir treatment. In conclusion, repeated administration of tenofovir in higher doses led to significant decrease of the relative proportion of active liver microsomal CYPs accompanied by a conversion of these enzymes to the inactive form (CYP420) maintaining the sum of CYP proteins unchanged.

scholarly journals Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-Metabolizing Enzymes in Vivo and in Vitro.

2001 ◽  
Vol 24 (5) ◽  
pp. 505-509 ◽  
Author(s):  
Yasuna KOBAYASHI ◽  
Naomi OHSHIRO ◽  
Tadanori SASAKI ◽  
Shogo TOKUYAMA ◽  
Takashi TOBE ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes ◽  
Microsomal Cytochrome ◽  
Microsomal Cytochrome P450
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