Induction Of Tissue-Type Plasminogen Activator By Ionizing Radiation In Human Malignant Melanoma Cells

1991 ◽  
pp. 220 ◽  
Author(s):  
DAVID A. BOOTHMAN ◽  
MEIZHI WANG ◽  
SAMUEL W. LEE
Keyword(s):  
Malignant Melanoma ◽  
Ionizing Radiation ◽  
Plasminogen Activator ◽  
Melanoma Cells ◽  
Tissue Type ◽  
Human Malignant Melanoma ◽  
Tissue Type Plasminogen Activator ◽  
Type Plasminogen Activator

Induction of tissue-type plasminogen activator and 72-kDa type-IV collagenase by ionizing radiation in rat astrocytes

1994 ◽  
Vol 56 (2) ◽  
pp. 214-218 ◽  
Author(s):  
Raymond Sawaya ◽  
Philip J. Tofion ◽  
Sanjeeva Mohanam ◽  
Francis Ali-Oosman ◽  
Lance A. Liotta ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Plasminogen Activator ◽  
Tissue Type ◽  
Type Iv Collagenase ◽  
Tissue Type Plasminogen Activator ◽  
Type Iv ◽  
Type Plasminogen Activator ◽  
Rat Astrocytes

Differential regulation of gelatinase b and tissue-type plasminogen activator expression in human bowes melanoma cells

1993 ◽  
Vol 53 (3) ◽  
pp. 395-400 ◽  
Author(s):  
Michel Houde ◽  
Georges De Bruyne ◽  
Marc Bracke ◽  
Magnus Ingelman-sundberg ◽  
GÓRan Skoglund ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Melanoma Cells ◽  
Differential Regulation ◽  
Tissue Type ◽  
Gelatinase B ◽  
Tissue Type Plasminogen Activator ◽  
Type Plasminogen Activator

scholarly journals Intracellular distribution of tissue-type plasminogen activator in human melanoma cells.

1988 ◽  
Vol 19 (1) ◽  
pp. 107-110
Author(s):  
Tetsuhiro SAKAI ◽  
Kiyotaka OKADA ◽  
Hiroshi BANDO ◽  
Hideharu FUKAO ◽  
Shigeru UESHIMA ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Intracellular Distribution ◽  
Tissue Type ◽  
Tissue Type Plasminogen Activator ◽  
Human Melanoma Cells ◽  
Type Plasminogen Activator

On the Composition and Function of the Carbohydrate Moiety of Tissue-Type Plasminogen Activator from Human Melanoma Cells

1985 ◽  
Vol 54 (04) ◽  
pp. 788-791 ◽  
Author(s):  
D C Rijken ◽  
J J Emeis ◽  
G J Gerwig
Keyword(s):  
Plasminogen Activator ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Tissue Type ◽  
Gas Liquid Chromatography ◽  
Tissue Type Plasminogen Activator ◽  
Human Melanoma Cells ◽  
Type Plasminogen Activator ◽  
And Function

SummaryTwo variants (I and II) of tissue-type plasminogen activator (t-PA) from human melanoma cells were separated by Lysine Sepharose chromatography. The carbohydrate compositions of the forms were determined by gas-liquid chromatography. Variant I contained 12.8 g and variant II 7.1 g of carbohydrate per 100 g protein. Both variants contained N-acetylgalactosamine, suggesting O-glycosylation in addition to N-glycosylation. The possible role of N-linked oligosaccharides for the biological activity of t-PA was studied using t-PA secreted by melanoma cells in the presence of tunicamycin, an inhibitor of N-glycosylation. The latter t-PA showed the same plasminogen activating and fibrin binding properties as normally glycosylated t-PA, indicating that N-linked carbohydrate is not involved in the fibrinolytic activity of t-PA.

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