Medicinal Chemistry Case History: Structure-Based Drug Design of Oral and Inhaled p38 MAP Kinase Inhibitors as Clinical Candidates

2017 ◽  
pp. 408-430
Author(s):  
L. Xing ◽  
J. Mathias
Keyword(s):  
Drug Design ◽  
Map Kinase ◽  
Case History ◽  
Medicinal Chemistry ◽  
Kinase Inhibitors ◽  
P38 Map Kinase ◽  
Structure Based Drug Design ◽  
P38 Map Kinase Inhibitors

scholarly journals Inhibition of Wnt/β-Catenin Signaling by p38 MAP Kinase Inhibitors Is Explained by Cross-Reactivity with Casein Kinase Iδ/ɛ

2011 ◽  
Vol 18 (4) ◽  
pp. 485-494 ◽  
Author(s):  
Folkert Verkaar ◽  
Antoon A. van der Doelen ◽  
Jos F.M. Smits ◽  
W. Matthijs Blankesteijn ◽  
Guido J.R. Zaman
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Cross Reactivity ◽  
P38 Map Kinase ◽  
Casein Kinase ◽  
P38 Map Kinase Inhibitors

p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones

2006 ◽  
Vol 16 (16) ◽  
pp. 4400-4404 ◽  
Author(s):  
Swaminathan R. Natarajan ◽  
David D. Wisnoski ◽  
James E. Thompson ◽  
Edward A. O’Neill ◽  
Stephen J. O’Keefe
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
P38 Map Kinase ◽  
P38 Map Kinase Inhibitors

Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood

2013 ◽  
Vol 56 (21) ◽  
pp. 8561-8578 ◽  
Author(s):  
Benjamin Baur ◽  
Kirsten Storch ◽  
Kathrin E. Martz ◽  
Marcia I. Goettert ◽  
André Richters ◽  
...  
Keyword(s):  
Map Kinase ◽  
Whole Blood ◽  
Kinase Inhibitors ◽  
P38 Map Kinase ◽  
Human Whole Blood ◽  
P38 Map Kinase Inhibitors

scholarly journals Design, Synthesis, and Biological Evaluation of Chromone-Based p38 MAP Kinase Inhibitors

2011 ◽  
Vol 54 (20) ◽  
pp. 7427-7431 ◽  
Author(s):  
Christine Dyrager ◽  
Linda Nilsson Möllers ◽  
Linda Karlsson Kjäll ◽  
John Patrick Alao ◽  
Peter Dinér ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
P38 Map Kinase ◽  
Design Synthesis ◽  
P38 Map Kinase Inhibitors ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Activities of 4-Phenyl-5-pyridyl-1,3-thiazole Derivatives as p38 MAP Kinase Inhibitors.

ChemInform ◽  
2005 ◽  
Vol 36 (39) ◽  
Author(s):  
Seiji Miwatashi ◽  
Yasuyoshi Arikawa ◽  
Ken-ichi Naruo ◽  
Keiko Igaki ◽  
Yasumasa Watanabe ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Biological Activities ◽  
P38 Map Kinase ◽  
Thiazole Derivatives ◽  
P38 Map Kinase Inhibitors

Process Research and Development for Heterocyclic p38 MAP Kinase Inhibitors

Synlett ◽  
2012 ◽  
Vol 23 (11) ◽  
pp. 1564-1574 ◽  
Author(s):  
Oliver Thiel ◽  
Michal Achmatowicz ◽  
Robert Milburn
Keyword(s):  
Research And Development ◽  
Map Kinase ◽  
Kinase Inhibitors ◽  
P38 Map Kinase ◽  
Process Research ◽  
P38 Map Kinase Inhibitors
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