Improved Approaches to Dose–Response Modeling of Toxicological and Adaptive Endpoints for Risk Assessment: Hormetic Dose Response

2018 ◽  
pp. 59-85
Author(s):  
Edward J. Calabrese
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Response Modeling

Sources of Uncertainty in Dose-Response Modeling of Epidemiological Data for Cancer Risk Assessment

1999 ◽  
Vol 895 (1 UNCERTAINTY I) ◽  
pp. 212-222 ◽  
Author(s):  
LESLIE STAYNER ◽  
A. JOHN BAILER ◽  
RANDALL SMITH ◽  
STEPHEN GILBERT ◽  
FAYE RICE ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Dose Response ◽  
Epidemiological Data ◽  
Cancer Risk Assessment ◽  
Sources Of Uncertainty ◽  
Response Modeling

Cancer risk assessment for 1,3-butadiene: Dose–response modeling from an epidemiological perspective

2007 ◽  
Vol 166 (1-3) ◽  
pp. 140-149 ◽  
Author(s):  
Robert L. Sielken ◽  
Ciriaco Valdez-Flores ◽  
Michael L. Gargas ◽  
Christopher R. Kirman ◽  
M. Jane Teta ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Dose Response ◽  
Cancer Risk Assessment ◽  
Response Modeling

scholarly journals The Maturing of Hormesis as a Credible Dose-Response Model

2003 ◽  
Vol 1 (3) ◽  
pp. 154014203902499 ◽  
Author(s):  
Edward J. Calabrese
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Comparative Evaluation ◽  
Threshold Model ◽  
Historical Evolution ◽  
Response Model ◽  
Critical Error ◽  
Toxicological Risk ◽  
Response Modeling ◽  
Toxicological Risk Assessment

Hormesis is a dose-response phenomenon that has received little recognition, credibility and acceptance as evidenced by its absence from major toxicological/risk assessment texts, governmental regulatory dose-response modeling for risk assessment, and non-visibility in major professional toxicological society national meetings. This paper traces the historical evolution of the hormetic dose-response hypothesis, why this model is not only credible but also more common than the widely accepted threshold model in direct comparative evaluation, and how the toxicological community made a critical error in rejecting hormesis, a rejection sustained over 70 years.

Dose–response modeling of in vivo genotoxicity data for use in risk assessment: some approaches illustrated by an analysis of acrylamide

2005 ◽  
Vol 41 (1) ◽  
pp. 6-27 ◽  
Author(s):  
Bruce Allen ◽  
Errol Zeiger ◽  
Greg Lawrence ◽  
Marvin Friedman ◽  
Annette Shipp
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Response Modeling
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