Bioactivity of Inhaled Methane and Interactions With Other Biological Gases

A number of studies have demonstrated explicit bioactivity for exogenous methane (CH4), even though it is conventionally considered as physiologically inert. Other reports cited in this review have demonstrated that inhaled, normoxic air-CH4 mixtures can modulate the in vivo pathways involved in oxidative and nitrosative stress responses and key events of mitochondrial respiration and apoptosis. The overview is divided into two parts, the first being devoted to a brief review of the effects of biologically important gases in the context of hypoxia, while the second part deals with CH4 bioactivity. Finally, the consequence of exogenous, normoxic CH4 administration is discussed under experimental hypoxia- or ischaemia-linked conditions and in interactions between CH4 and other biological gases, with a special emphasis on its versatile effects demonstrated in pulmonary pathologies.

PLEKHA5 regulates mitotic progression by promoting APC/C localization to microtubules

The anaphase-promoting complex/cyclosome (APC/C) coordinates advancement through mitosis via temporally controlled polyubiquitination of effector proteins. Despite the long-appreciated spatial organization of key events in mitosis mediated largely by cytoskeletal networks, the spatial regulation of APC/C, the major mitotic E3 ligase, is poorly understood. Here, we describe a microtubule-resident protein, PLEKHA5, as an interactor of APC/C and spatial regulator of its activity in mitosis. PLEKHA5 knockdown delayed mitotic progression, causing accumulation of APC/C substrates dependent upon the PLEKHA5-APC/C interaction. A microtubule-localized proximity biotinylation tool revealed that depletion of PLEKHA5 decreased the extent of APC/C association with microtubules. This decreased APC/C microtubule-localization in turn prevented efficient loading of APC/C with its co-activator CDC20, leading to defects in E3 ligase catalytic activity. We propose that PLEKHA5 functions as an adaptor of APC/C that promotes its subcellular localization to microtubules and facilitates its activation by CDC20, thus ensuring the timely turnover of key mitotic APC/C substrates and proper progression through mitosis.

Taxonomic and nomenclatural inventory of the Umbelliferae in Central Asia, described on the basis of collections of the National Herbarium of Uzbekistan

The National Herbarium of Uzbekistan (TASH) in Tashkent is the oldest and largest botanical collection not only in Uzbekistan, but also in the entire region of Central Asia. The article presents a complete inventory of the type material of Umbelliferae taxa stored in the National Herbarium of Uzbekistan (TASH), as well as some key events of the TASH history and its main personalities. The herbarium in its current state is a result of merging of seven Uzbekistanian herbaria. TASH played a special role in the studies of Central Asian Umbelliferae (Apiaceae). TASH currently holds type specimens of 130 taxa of Umbelliferae, including 125 species and 5 intraspecific taxa (according to the ranks proposed in protologues). The TASH Umbelliferae type collection contains holotypes of 82 taxa, lectotypes of 36 taxa, isolectotypes of 22 taxa, syntypes of 15 taxa, and isotypes of 19 taxa. The names of 54 taxa have been preserved in the modern nomenclature of the Umbelliferae, whereas the names of 46 and 33 taxa are now considered as nomenclatural and taxonomic synonyms. Four lectotypes are designated here

The Elusive Balkan Spark: 28 June 1914, Again and Always

The assassination of Franz Ferdinand on 28 June 1914 in Sarajevo justifiably continues to attract the attention of historians as one of the key events in the history of the modern world. This review essay examines several recent scholarly contributions published in a collection of essays devoted to the theme. It highlights the ongoing controversies and contradictory interpretations surrounding the subject.

Ville et Evenement : Analyse de l’inscription Territoriale de la « Fete du 15 Aout » Dans la Ville de Savalou (Centre Benin)

Les villes accueillent souvent des évènements qui, de par leur nature et les manifestations qu’ils engendrent, marquent la trame urbaine et contribuent au développement local. Le but de la présente recherche est d’analyser l’inscription territoriale de la « fête du 15 août », le plus important évènement qu’accueille, chaque année, la ville de Savalou. L’approche méthodologique adoptée combine les recherches documentaires notamment sur la thématique ville et évènement, les enquêtes de terrain à travers l’observation participante des manifestations des éditions 2019 et 2021 de la fête du 15 août, les entretiens semi directifs avec les autorités communales et les questionnaires avec les promoteurs de réceptifs hôteliers, de restaurants ainsi que quelques forains et visiteurs urbains. Au total, 173 personnes ont été interrogées dans le cadre de cette recherche. Ces personnes ont été retenues par la méthode de choix raisonné. Les méthodes d’analyse de contenu et de statistiques descriptives ont permis de traiter les données et informations recueillies et le modèle SWOT ou FFOM (Forces, Faiblesses, Opportunités et Menaces) a été utilisé pour analyser les résultats obtenus. Il ressort des analyses que cinq (05) manifestations clés sont organisées dans le cadre de la « fête du 15 août » : il s’agit du rituel d’autorisation de la consommation des nouvelles ignames, la Grande Foire Artisanale de Savalou (GFAS), l’élection de Miss Savalou (la plus belle fille de la Commune de Savalou), la finale de la coupe de football de la commune et les concerts. Au plan spatial, l’évènement se déroule en plusieurs lieux à savoir le palais royal, la paroisse de l’église catholique, la maison des jeunes, le stade omnisport de la ville, la place Soha et le site de la foire. Il n’existe pas une structure officielle qui assure le portage de l’évènement ; chaque manifestation est organisée par un acteur donné sans qu’aucune coordination ne soit mise en place. Par ailleurs, très peu de recettes sont collectées par la mairie à l’occasion de cet évènement. On en déduit que l’évènement profite financièrement plus aux acteurs privés qu’à la municipalité. Cities often host events which, by their nature and the events they generate, mark the urban fabric and contribute to local development. The aim of this research is to analyze the territorial inscription of the "feast of August 15", the most important event hosted each year by the city of Savalou. The methodological approach adopted combines documentary research, in particular on the city and event theme, field surveys through the participant observation of the events of the 2019 and 2021 editions of the August 15 festival, semi-structured interviews with the municipal authorities and questionnaires with the promoters of hotel receptives, restaurants as well as a few fairgrounds and urban visitors. A total of 173 people were interviewed for this research. These people were selected by the reasoned choice method. The methods of content analysis and descriptive statistics were used to process the data and information collected and the SWOT or SWOT model (Strengths, Weaknesses, Opportunities and Threats) was used to analyze the results obtained. It emerges from the analyzes that five (05) key events are organized within the framework of the “feast of August 15”: it is about the ritual of authorization of the consumption of new yams, the Great Artisanal Fair of Savalou (GFAS) , the election of Miss Savalou (the most beautiful girl in the Municipality of Savalou), the final of the municipal football cup and the concerts. Spatially, the event takes place in several locations, namely the Royal Palace, the parish of the Catholic Church, the youth center, the city's sports stadium, Soha Square and the site of the fair. There is no official structure that ensures the portering of the event; each event is organized by a given actor without any coordination being put in place. In addition, very little revenue is collected by the town hall during this event. We deduce that the event financially benefits private actors more than the municipality.

Role of Football in International Business and Economy

Football events are one of the most significant sports events globally while football is one of the most popular sports. Thus, the football industry and football-related businesses plays an important role in trade and economy. In the current study key events and top associations and organizations of the football industry are identified, and their role beyond playing grounds is observed. Also, the role the football industry plays in the economic and financial developments of nations, brands and organizations and individuals is highlighted. A comprehensive chart has been drawn that presents a comprehensive structure of the global football industry and also identifies key sources of revenue and expenditures. The study is important for scholars interested in sports economics and sustainable economic development through sports.

Obchody rocznicy Chopina w roku 1910 a integracja narodowa. Chopin a kultura pamięci

The article presents the events of the celebration of Chopin’s 100th birthday in 1910. The article is based on the accounts published in the daily press of the time. The growth of Chopin’s cult in Polish lands culturally connected the nation divided both politically and administratively between three countries (Austria, Prussia and Russia). Despite disruptions by the police that inhibited the organisation of the celebrations in Poznan and Warsaw, the Polish people treated them as a nation-wide occasion and used that time to integrate. The key events were the 50th anniversary of Chopin’s death (1899) and the 100th anniversary of his birthday (1910). The year 1910 was also the 500th anniversary of the Battle of Grunwald which saw the Poles defeat the Germans. Chopin’s year had immense patriotic meaning and integrated the nation living under foreign rule.

Feline hypertrophic cardiomyopathy: reduced microvascular density and involvement of CD34+ interstitial cells

The sequence of pathological events in feline hypertrophic cardiomyopathy (fHCM) is still largely unknown, although we know that fHCM is characterized by interstitial remodeling in a macrophage-driven pro-inflammatory environment and that myocardial ischemia might contribute to its progression. This study aimed to gain further insights into the structural changes associated with interstitial remodeling in fHCM with special focus on the myocardial microvasculature and the phenotype of the interstitial cells. Twenty-eight hearts (16 hearts with fHCM and 12 without cardiac disease) were evaluated in the current study, with immunohistochemistry, RNA-in situ hybridization, and transmission electron microscopy. Morphometrical evaluations revealed a statistically significant lower microvascular density in fHCM. This was associated with structural alterations in capillaries that go along with a widening of the interstitium due to the accumulation of edema fluid, collagen fibers, and mononuclear cells that also proliferated locally. The interstitial cells were mainly of fibroblastic or vascular phenotype, with a substantial contribution of predominantly resident macrophages. A large proportion expressed CD34 mRNA, which suggests a progenitor cell potential. Our results indicate that microvascular alterations are key events in the pathogenesis of fHCM and that myocardial interstitial cell populations with CD34+ phenotype play a role in the pathogenesis of the disease.