LncRNAs (long non-coding RNAs) are endogenous molecules, involved in complicated biological
processes. Increasing evidence has shown that lncRNAs play a vital role in the post-stroke pathophysiology.
Furthermore, several lncRNAs were reported to mediate ischemia cascade processes include apoptosis, bloodbrain
barier breakdown, angiogenesis, microglial activation induced neuroinflammation which can cause neuron
injury and influence neuron recovery after ischemic stroke. In our study, we first summarize current development
about lncRNAs and post-stroke, focus on the regulatory roles of lncRNAs on pathophysiology after stroke. We
also reviewed genetic variation in lncRNA associated with functional outcome after ischemic stroke. Additionally,
lncRNA-based therapeutics offer promising strategies to decrease brain damage and promote neurological
recovery following ischemic stroke. We believe that lncRNAs will become promising for the frontier strategies
for IS and can open up a new path for the treatment of IS in the future.
Stroke Recovery with Cellular Therapies. 2008. Edited by Sean I. Savitz, Daniel M. Rosenbaum. Published by Humana Press. 166 pages. Price C$100.
