Diabetic Emergencies: Ketoacidosis, Hyperglycemic Hyperosmolar State, and Hypoglycemia

2022 ◽  
pp. 167-182
Author(s):  
Heidi Guzman ◽  
David Wing-Hang Lam
Keyword(s):  
Hyperglycemic Hyperosmolar State

Alpelisib-induced coexisting of Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State in Metastatic Breast Cancer

2021 ◽  
Author(s):  
Li-Ching Li ◽  
Yi-Sun YANG ◽  
Edy Kornelius ◽  
Shih-Chang Lo ◽  
Chien-Ning Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Diabetic Ketoacidosis ◽  
Metastatic Breast ◽  
Hyperglycemic Hyperosmolar State

scholarly journals Hyperglycemic Hyperosmolar State (HHS) with New-onset Diabetes Mellitus in a Patient with SARS CoV-2 Infection.

2020 ◽  
Author(s):  
Awaji Q. Al-Naami ◽  
Liaqat Ali Khan ◽  
Faisal I. Zaidan ◽  
Ibrahim A. Al-Neami ◽  
Akram S. Awad ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Complications ◽  
Onset Diabetes ◽  
Hyperglycemic Hyperosmolar State ◽  
New Onset Diabetes Mellitus ◽  
New Onset

New-onset DM or unmasking existing one, with or without metabolic complications, has been reported in SARS CoV-2 infection. New-onset DM in association with HHS alone or combination with DKA is uncommon but a possible manifestation of SARS CoV-2 infection that poses management challenges where the outcome may be worst.

scholarly journals Clinical profiles, outcomes and risk factors among type 2 diabetic inpatients with diabetic ketoacidosis and hyperglycemic hyperosmolar state: a hospital-based analysis over a 6-year period

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiao-yan Wu ◽  
Dun-min She ◽  
Fang Wang ◽  
Gang Guo ◽  
Ran Li ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Diabetic Ketoacidosis ◽  
Protective Factor ◽  
Diabetic Patients ◽  
Spearman Correlation ◽  
C Peptide ◽  
Arterial Blood ◽  
Hyperglycemic Hyperosmolar State ◽  
Type 2 Diabetic

Abstract Objective Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are the two most common hyperglycemic emergencies (HEs) associated with diabetes mellitus. Individuals with HEs can present with combined features of DKA and HHS. The objective of this study is to assess the clinical characteristics, therapeutic outcomes, and associated predisposing factors of type 2 diabetic patients with isolated or combined HEs in China. Methods We performed a retrospective analysis of 158 patients with type 2 diabetes (T2DM), complicated with DKA, HHS, or DKA combined with HHS (DKA-HHS) in Shanghai Tongji Hospital, China from 2010 to 2015. Admission clinical features, therapeutic approaches and treatment outcomes of those patients were extracted and analyzed. Results Of the 158 patients with T2DM, 65 (41.1%) patients were DKA, 74 (46.8%) were HHS, and 19 (12.0%) were DKA-HHS. The most common precipitants were infections (111, 70.3%), newly diagnosed diabetes (28,17.7%) and non-compliance to medications (9, 5.7%). DKA patients were divided into mild, moderate and severe group, based on arterial blood gas. Spearman correlation analysis revealed that C-reaction protein (CRP) was positively correlated with severity of DKA, whereas age and fasting C peptide were inversely correlated with severity of DKA (P < 0.05). The mortality was 10.8% (17/158) in total and 21.6% (16/74) in the HHS group, 5.9% (1/17) in DKA-HHS. Spearman correlation analysis indicated that death in patients with HHS was positively correlated to effective plasma osmolality (EPO), renal function indicators and hepatic enzymes, while inversely associated with the continuous subcutaneous insulin infusion (CSII) therapy. Logistic regression analysis suggested that elevated blood urea nitrogen (BUN) on admission was an independent predisposing factor of mortality in HHS, while CSII might be a protective factor for patients with HHS. Furthermore, the receiver-operating characteristic (ROC) curve analysis indicated that BUN had the largest area under the ROC curves for predicting death in patients with HHS. Conclusions Our findings showed elevated CRP and decreased fasting C-peptide might serve as indicator for severe DKA. Elevated BUN might be an independent predictor of mortality in patients with HHS, whereas CSII might be a protective factor against death in HHS.

scholarly journals A Case of Hyperglycemic Hyperosmolar State Associated with Graves' Hyperthyroidism: A Case Report

2006 ◽  
Vol 21 (4) ◽  
pp. 765 ◽  
Author(s):  
Sung Won Moon ◽  
Jong Ryeal Hahm ◽  
Gyeong-Won Lee ◽  
Mi Yeon Kang ◽  
Jung Hwa Jung ◽  
...  
Keyword(s):  
Case Report ◽  
Hyperglycemic Hyperosmolar State

Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State

2013 ◽  
Vol 42 (4) ◽  
pp. 677-695 ◽  
Author(s):  
Jelena Maletkovic ◽  
Andrew Drexler
Keyword(s):  
Diabetic Ketoacidosis ◽  
Hyperglycemic Hyperosmolar State

Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State

2003 ◽  
Author(s):  
Abbas E. Kitabchi ◽  
Guillermo E. Umpierrez ◽  
Mary Beth Murphy
Keyword(s):  
Diabetic Ketoacidosis ◽  
Hyperglycemic Hyperosmolar State

Black Esophagus: Acute Esophageal Necrosis in Hyperglycemic Hyperosmolar State

2016 ◽  
Vol 111 ◽  
pp. S788-S789
Author(s):  
Yong Yan ◽  
Lorenzo F. Ottaviano ◽  
Eduardo Quintero ◽  
Demetrios Tzimas ◽  
Jonathan M. Buscaglia
Keyword(s):  
Acute Esophageal Necrosis ◽  
Esophageal Necrosis ◽  
Black Esophagus ◽  
Hyperglycemic Hyperosmolar State
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