Asymmetric Phase-Transfer Catalysis as a Powerful Tool in the Synthesis of Biologically Active Chiral Complex Natural Products

2014 ◽  
pp. 409-435 ◽  
Author(s):  
Guddeangadi N. Gururaja ◽  
Mario Waser
Keyword(s):  
Natural Products ◽  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Biologically Active ◽  
Chiral Complex

ChemInform Abstract: Bifunctional Phase-Transfer Catalysis in the Asymmetric Synthesis of Biologically Active Isoindolinones.

ChemInform ◽  
2016 ◽  
Vol 47 (10) ◽  
pp. no-no
Author(s):  
Antonia Di Mola ◽  
Maximilian Tiffner ◽  
Francesco Scorzelli ◽  
Laura Palombi ◽  
Rosanna Filosa ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Biologically Active

scholarly journals ENVIRONMENTALLY FRIENDLY NAPHTOINDOLE CONTAINING AZO DYES

2013 ◽  
Vol 12 (24) ◽  
pp. 47-53
Author(s):  
Elizbar ELIZBARASHVILI ◽  
Ketevan KUPATADZE
Keyword(s):  
Azo Dyes ◽  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Biologically Active ◽  
Disperse Dyes ◽  
The Novel ◽  
Light Yellow ◽  
Red Color ◽  
Polyester Fibers ◽  
Semi Empirical

In the present article there are discussed the ways of synthesis of some azo-dyes from less active aromatic compounds, including biologically active ones. The novel naphtho[1,2-g]indole and naphtho[2,1-g]indole containing azo dyes have been synthesized in the non-polar organic media under phase transfer catalysis. Obtained disperse dyes are suitable for dyeing nylon and polyester fibers from light yellow to red color with good-excellence dyeing levelness, light, washing and sublimation fastness. The resulting azo dyes may be characterized as the less toxic compounds due to non-toxic metabolism reagents. Additionally, the quantumchemical calculations have been performed using quantum mechanical (MM2) and semi-empirical (AM1) methods, which allow to predict the activity of dyes against AhR ligand.

scholarly journals Bifunctional phase-transfer catalysis in the asymmetric synthesis of biologically active isoindolinones

2015 ◽  
Vol 11 ◽  
pp. 2591-2599 ◽  
Author(s):  
Antonia Di Mola ◽  
Maximilian Tiffner ◽  
Francesco Scorzelli ◽  
Laura Palombi ◽  
Rosanna Filosa ◽  
...  
Keyword(s):  
Large Scale ◽  
Phase Transfer Catalysis ◽  
Phase Transfer ◽  
Total Yield ◽  
Biologically Active ◽  
Chiral Compound ◽  
Biologically Relevant ◽  
Sedative Activity ◽  
Synthetic Routes ◽  
Derivatives Of

New bifunctional chiral ammonium salts were investigated in an asymmetric cascade synthesis of a key building block for a variety of biologically relevant isoindolinones. With this chiral compound in hand, the development of further transformations allowed for the synthesis of diverse derivatives of high pharmaceutical value, such as the Belliotti (S)-PD172938 and arylated analogues with hypnotic sedative activity, obtained in good overall total yield (50%) and high enantiomeric purity (95% ee). The synthetic routes developed herein are particularly convenient in comparison with the current methods available in literature and are particularly promising for large scale applications.

Biologically active natural products from Cassine viburnifolia

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
T Grkovic ◽  
R Akee ◽  
J Evans ◽  
JM Collins ◽  
B O'Keefe
Keyword(s):  
Natural Products ◽  
Biologically Active ◽  
Active Natural
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