Pharmacokinetic methods for TDM data analysis and optimal individualization of drug dosage regimens

2020 ◽  
pp. 135-168
Author(s):  
Roger Jelliffe ◽  
Michael Neely ◽  
David Bayard
Keyword(s):  
Data Analysis ◽  
Drug Dosage ◽  
Dosage Regimens

Dosage Regimen Adjustments in Renal Impairment

1973 ◽  
Vol 7 (9) ◽  
pp. 382-387 ◽  
Author(s):  
Donald L. Giusti ◽  
William L. Hayton
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Renal Impairment ◽  
Creatinine Clearance ◽  
Dosage Regimen ◽  
Drug Dosage ◽  
Loading Dose ◽  
Dosage Regimens ◽  
Drug Dosage Regimen ◽  
Pharmacokinetic Approach

A pharmacokinetic approach based on creatinine clearance has been outlined which permits drug dosage regimen adjustments in patients with renal impairment. The parameters needed for calculating a loading dose and a maintenance regimen are the fraction of a dose excreted unchanged in the urine, the creatinine clearance of the patient, and the half-life of the drug in patients with normal renal function. In varying degrees of renal failure, predicted dosage regimens agree closely with dosage regimens predicted by other methods for a number of drugs.

Estimation of drug dosage regimens with a pharmacokinetic slide rule

1977 ◽  
Vol 34 (2) ◽  
pp. 197-200
Author(s):  
Arthur B. Straughn ◽  
Charles A. Cruze ◽  
Marvin C. Meyer
Keyword(s):  
Drug Dosage ◽  
Slide Rule ◽  
Dosage Regimens

Optimal drug dosage regimens in cancer chemotherapy with neural networks

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 2134-2134
Author(s):  
A. G. Floares ◽  
C. Floares ◽  
M. Cucu ◽  
M. Marian ◽  
L. Lazar
Keyword(s):  
Neural Networks ◽  
Cancer Chemotherapy ◽  
Drug Dosage ◽  
Dosage Regimens ◽  
Optimal Drug

scholarly journals The significance of a new parameter – plasma protein binding – in therapeutic drug monitoring and its application to carbamazepine in epileptic patients

RSC Advances ◽  
2017 ◽  
Vol 7 (45) ◽  
pp. 28048-28055 ◽  
Author(s):  
Jing-lin Gao ◽  
Xin-yu Wang ◽  
Jing An ◽  
Chao-hui Du ◽  
Meng-jiao Li ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Drug Monitoring ◽  
Drug Dosage ◽  
Therapeutic Drug ◽  
Dosage Regimens ◽  
Epileptic Patients

The primary cause of the variability of Cf in pharmacology is the change in plasma protein binding (PPB), thus PPB monitoring should be applied to a better individualization of drug dosage regimens in clinical patients.

Optimal drug dosage regimens in cancer chemotherapy with neural networks

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 2134-2134 ◽  
Author(s):  
A. G. Floares ◽  
C. Floares ◽  
M. Cucu ◽  
M. Marian ◽  
L. Lazar
Keyword(s):  
Neural Networks ◽  
Cancer Chemotherapy ◽  
Drug Dosage ◽  
Dosage Regimens ◽  
Optimal Drug
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