Eptifibatide provides additional platelet inhibition in non–ST-elevation myocardial infarction patients already treated with aspirin and clopidogrel: results of the platelet activity extinction in non–Q-wave myocardial infarction with aspirin, clopidogrel, and eptifibatide (PEACE) study

2004 ◽  
Vol 13 (4) ◽  
pp. 42 ◽  
Author(s):  
M. Dalby ◽  
G. Montalescot ◽  
C.B. Sollier
Keyword(s):  
Myocardial Infarction ◽  
Platelet Inhibition ◽  
St Elevation Myocardial Infarction ◽  
Platelet Activity ◽  
St Elevation ◽  
Peace Study ◽  
Q Wave

Impact of vomiting on P2Y12 platelet inhibition in patients with ST-elevation myocardial infarction: A prespecified subanalysis of the ON-TIME 3 trial

2022 ◽  
Vol 243 ◽  
pp. 39-42
Author(s):  
Anne  H. Tavenier ◽  
Renicus  S. Hermanides ◽  
Jan  Paul. Ottervanger ◽  
Svetlana  V. Belitser ◽  
Olaf.  H. Klungel ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Platelet Inhibition ◽  
St Elevation Myocardial Infarction ◽  
St Elevation

scholarly journals In the transition from fibrinolysis to primary PCI, the HERO trials help refine STEMI ECG interpretation and Q wave analysis potentially alters future management

2018 ◽  
Vol 9 (1_suppl) ◽  
pp. 26-33
Author(s):  
Cheuk-Kit Wong ◽  
Harvey D White
Keyword(s):  
Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Symptom Onset ◽  
Coronary Intervention ◽  
St Elevation Myocardial Infarction ◽  
Time Duration ◽  
Duration Of Symptoms ◽  
Percutaneous Coronary ◽  
St Elevation ◽  
Q Wave

Electrocardiogram sub-studies from the Hirulog Early Reperfusion/Occlusion 1 and 2 trials, which tested bivalirudin as an adjunctive anticoagulant to fibrinolysis in ST-elevation myocardial infarction, have contributed to the literature. The concept of using the presence of infarct lead Q waves to determine reperfusion benefit has subsequently been explored in multiple primary percutaneous coronary intervention studies. The angiographic findings before percutaneous coronary intervention combine with the baseline electrocardiogram to accurately diagnose ST-elevation myocardial infarction and evaluate its potential territory. This review discusses the relative merits of the presence of infarct lead Q waves versus time duration from symptom onset using observational data from cohorts of patients from multiple clinical trials. The presence of infarct lead Q waves at presentation has been repeatedly shown to be superior to time duration from symptom onset in determining prognosis, despite that continuous variable (time duration) statistically should be more powerful than dichotomous variable (Q wave). If quantitative or semi-quantitative measurement of Q waves correlates well with irreversible myocardial injury in vivo (a research goal of many cardiac magnetic resonance imaging studies), Q waves measurements by mirroring ST-elevation myocardial infarction evolution better than the current metric of time duration of symptoms will impact future ST-elevation myocardial infarction reperfusion management. Newer methodology will more quickly capture and transmit electrocardiogram information including infarct lead Q waves potentially before first medical contact, and help differentiate new evolving Q waves of the ongoing ST-elevation myocardial infarction from old changes. Q waves as the new metric in ST-elevation myocardial infarction reperfusion should be tested in upcoming trials.

scholarly journals The Quantitative Measurement of ST-Segment Deviation and Pathological Q Wave for Predicting Hospitalization Mortality in Patient with ST-Elevation Myocardial Infarction

2019 ◽  
Vol 40 (3) ◽  
Author(s):  
Muhammad Surya Tiyantara ◽  
Yustye Yustye ◽  
Djoen Herdianto ◽  
Swandari Paramita
Keyword(s):  
Myocardial Infarction ◽  
Hospital Mortality ◽  
Quantitative Measurement ◽  
St Elevation Myocardial Infarction ◽  
Operating Characteristics ◽  
St Segment ◽  
St Elevation ◽  
The Waves ◽  
Grace Score ◽  
Q Wave

Background: The appearance of ST-segment elevation (STE) and pathological Q wave were signs of worse myocardial damage and function, the quantitative measurement of the waves have a potential prognosis role. This study assesses the performance of the quantitative measurement of the waves in predicting in-hospital mortality and compares it with the Global Registry of Acute Coronary Events (GRACE) score as the standard recommended risk score. Methods: This was a cross-sectional study included patients with ST-elevation myocardial infarction (STEMI) that hospitalized in Abdul Wahab Sjahranie General Hospital Samarinda during January to December 2016. Standard 12-lead electrocardiograms (ECG) were assessed at patient admission as well as other data for GRACE score. The subjects were grouped into non-survivor and survivor group based on hospitalization survival state, and six quantitative ECG characteristics performance will be assessed. The performances were assessed using receiver operating characteristics (ROC) curve and area under the curve (AUC). Results: There were 57 subjects consisting of 9 non-survivor subjects. The AUC of the four ECG characteristics highest STE amplitude, deepest Q amplitude, total Q amplitude, and total STE amplitude did not significantly different with GRACE score (p>0.05). Highest STE amplitude has the best performance than the other ECG characteristics (AUC=0.81, 95% CI:0.65 to 0.97), and cut off point 4.5mm provides 56% sensitivity and 94% specificity. Conclusion: The quantitative measurement of ST-segment deviation and pathological Q wave have the prognosis role for predicting in-hospital mortality.

Sign in / Sign up

Export Citation Format

Share Document