Cerebral oximetry with blood volume index and capnography in intubated and hyperventilated patients

2016 ◽  
Vol 34 (6) ◽  
pp. 1102-1107 ◽  
Author(s):  
Taylor A. Bagwell ◽  
Thomas J. Abramo ◽  
Gregory W. Albert ◽  
Jonathan W. Orsborn ◽  
Elizabeth A. Storm ◽  
...  
Keyword(s):  
Blood Volume ◽  
Cerebral Oximetry ◽  
Volume Index

Abstract T P371: Utility of Cerebral Oximetry with Cerebral Blood Volume Index (CBVI) in Detecting Pediatric Strokes

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Thomas J Abramo ◽  
Lori Jordan ◽  
Zeah Harris ◽  
Mark Meredith ◽  
Mark Meredith ◽  
...  
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Screening Tool ◽  
Altered Mental Status ◽  
Contralateral Side ◽  
Cerebral Oximetry ◽  
Volume Index ◽  
Pediatric Stroke ◽  
Cerebral Pathology ◽  
Stroke Knowledge

Pediatric Strokes are increasing with recognition and imaging delays. Limited pediatric stroke knowledge, vague signs & symptoms and no reliable stroke detection tools is the cause. Improving recognition improves outcomes. Objective: To assess utility of Left & Right Cerebral rcSO2 and cerebral blood volume index (CBVI) in Pediatric Stroke Alert and Altered Mental Status (AMS) patients. Methods: Observational study of Stroke Alert & AMS patient’s Cerebral rcSO2 and CBVI. Stroke rcSO2 and CBVI values in stroke patients were compared to controls & AMS (no cerebral pathology) patients. Results: Controls (N=133), Stroke alert (N=25) & AMS stroke (N=52)'s rcSO2, CBVI means were consistent 0-60 minutes. Lower rcSO2 with or without CBVI readings correlated with stroke (Left rcSO2, CBVI (P<0.0001), Right rcSO2 (P=0.0038), CBVI (p=0.0006)). A 19.1% rcSO2 side difference had 100% PPV for stroke. Across 0-60 minutes, rcSO2, CBVI were consistent for stroke & type (Hemorrhagic or Ischemic) (P<0.0001). Left Stroke’s rcSO2, CBVI were lower than Right Strokes (P<0.0001). Hemorrhagic ipsilateral stroke and contralateral side had lower rcSO2, CBVI (P<0.001) then Ischemic. Conclusion: The rcSO2, CBVI difference between sidess objectively and consistently detected stroke, location, and stroke types (Hemorrhagic or Ischemic). A 19.1% rcSO2 differencehad had 100% PPV for detecting strokes demonstrating cerebral oximetry’s utility. Cerebral Oximetry with CBVI has shown its’ potential as an objective screening tool for identify pediatric strokes and types. Cerebral Oximetry with CBVI has potential for expediting stroke recognition and decreasing imaging time.

Cerebral oximetry with blood volume index in asystolic pediatric cerebrospinal fluid malfunctioning shunt patients

2014 ◽  
Vol 32 (11) ◽  
pp. 1439.e1-1439.e7 ◽  
Author(s):  
Thomas J. Abramo ◽  
Mark Meredith ◽  
Mathew Jaeger ◽  
Bradford Schneider ◽  
Holli Bagwell ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Blood Volume ◽  
Cerebral Oximetry ◽  
Volume Index

Cerebral oximetry with cerebral blood volume index in detecting pediatric stroke in a pediatric ED

2015 ◽  
Vol 33 (11) ◽  
pp. 1622-1629 ◽  
Author(s):  
Thomas J. Abramo ◽  
Z. Leah Harris ◽  
Mark Meredith ◽  
Kristen Crossman ◽  
Rawle Seupaul ◽  
...  
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Cerebral Oximetry ◽  
Volume Index ◽  
Pediatric Stroke

Cerebral blood volume index as a predictor of functional independence after basilar artery thrombectomy

2021 ◽  
Author(s):  
Rahul R. Karamchandani ◽  
Dale Strong ◽  
Jeremy B. Rhoten ◽  
Tanushree Prasad ◽  
Jacob Selig ◽  
...  
Keyword(s):  
Blood Volume ◽  
Basilar Artery ◽  
Cerebral Blood Volume ◽  
Functional Independence ◽  
Volume Index

Intrathoracic blood volume index measured by thermodilution for preload monitoring after cardiac surgery

2002 ◽  
Vol 16 (2) ◽  
pp. 191-195 ◽  
Author(s):  
Daniel A. Reuter ◽  
Thomas W. Felbinger ◽  
Karl Moerstedt ◽  
Florian Weis ◽  
Christian Schmidt ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Volume ◽  
Intrathoracic Blood Volume ◽  
Volume Index ◽  
Intrathoracic Blood Volume Index

scholarly journals Intracranial pressure dynamics in patients with acute brain damage

1997 ◽  
Vol 82 (4) ◽  
pp. 1270-1282 ◽  
Author(s):  
M. Ursino ◽  
C. A. Lodi ◽  
S. Rossi ◽  
N. Stocchetti
Keyword(s):  
Intracranial Pressure ◽  
Brain Damage ◽  
Blood Volume ◽  
Time Constant ◽  
Cerebral Blood Volume ◽  
Volume Index ◽  
Parameter Estimates ◽  
Time Pattern ◽  
Pressure Dynamics ◽  
Parameter Values

Ursino, M., C. A. Lodi, S. Rossi, and N. Stocchetti.Intracranial pressure dynamics in patients with acute brain damage. J. Appl. Physiol. 82(4): 1270–1282, 1997.—The time pattern of intracranial pressure (ICP) during pressure-volume index (PVI) tests was analyzed in 20 patients with severe acute brain damage by means of a simple mathematical model. In most cases, a satisfactory fitting between model response and patient data was achieved by adjusting only four parameters: the cerebrospinal fluid (CSF) outflow resistance, the intracranial elastance coefficient, and the gain and time constant of cerebral autoregulation. The correlation between the parameter estimates was also analyzed to elucidate the main mechanisms responsible for ICP changes in each patient. Starting from information on the estimated parameter values and their correlation, the patients were classified into two main classes: those with weak autoregulation (8 of 20 patients) and those with strong autoregulation (12 of 20 patients). In the first group of patients, ICP mainly reflects CSF circulation and passive cerebral blood volume changes. In the second group, ICP exhibits paradoxical responses attributable to active changes in cerebral blood volume. Moreover, in two patients of the second group, the time constant of autoregulation is significantly increased (>40 s). The correlation between the parameter estimates was significantly different in the two groups of patients, suggesting the existence of different mechanisms responsible for ICP changes. Moreover, analysis of the correlation between the parameter estimates might give information on the directions of parameter changes that have a greater impact on ICP.

Rattlesnake venom shock in the rat: development of a method

1975 ◽  
Vol 229 (6) ◽  
pp. 1668-1674 ◽  
Author(s):  
RW Carlson ◽  
Schaeffer RC ◽  
H Whigham ◽  
S Michaels ◽  
FE Russell ◽  
...  
Keyword(s):  
Blood Volume ◽  
Cell Mass ◽  
Volume Index ◽  
Control Group ◽  
Physiological Salt Solution ◽  
Total Blood ◽  
Crotalus Viridis ◽  
Perfusion Failure ◽  
Red Cell Mass ◽  
Disappearance Curve

A model in Wistar rats (n = 30, 279-345 g) was developed to study circulatory, respiratory, metabolic, and lethal effects of an intravenous infusion (30 min; 1.25, 1.5, 1.75, and 2.0 mg/kg) of rattlesnake (Crotalus viridis helleri) venom. Venom produced perfusion failure with lactacidemia, hemoconcentration, hypoproteinemia, and death. The severity of poisoning was proportional to the quantity of venom given and to the elevation in lactic acid and hematocrit. Hemorrhages in the diaphragm, intercostal muscles, and intestine were observed at necropsy. In a separate test, rats (n = 12, 311-355 g) received an infusion of 1.5 mg/kg of venom or physiological salt solution. Blood volume was measured 30 min after the end of infusion in both groups with radioiodinated (125I) human serum albumin (RIHSA) and 51Cr-labeled rat red cells. Venom produced a significant reduction in total blood volume index (35%, P less than 0.001), plasma volume index (46%, P less than 0.001), and red cell mass indec (22% P less than 0.005). The slope of the RIHSA-disappearance curve of animals that received venom was more than twice that of the control group. We conclude that perfusion failure following rattlesnake envenomation is associated with hypovolemia due to increases in vascular permeabiltiy and hemorrhage.

Abstract P557: Hypoperfusion Intensity Ratio and Cerebral Blood Volume Index as Predictors of Outcome for Recanalized Middle Cerebral Artery Occlusions

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Jonathan M Parish ◽  
Dale Strong ◽  
Tanushree Prasad ◽  
Jeremy B Rhoten ◽  
Jonathan D Clemente ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Computerized Tomography ◽  
Blood Volume ◽  
Cerebral Artery ◽  
Intensity Ratio ◽  
Cerebral Blood Volume ◽  
Favorable Outcome ◽  
Volume Index ◽  
Collateral Flow ◽  
Mca Occlusion

Introduction: Preliminary data suggest the Hypoperfusion Intensity Ratio (HIR) and the Cerebral Blood Volume Index (CBVI) derived from Computerized Tomography Perfusion (CTP) imaging predict the rate of collateral flow, speed of infarct growth, and clinical outcome. We hypothesized that functional outcomes at hospital discharge would be significantly better for middle cerebral artery (MCA) occlusion patients achieving Thrombolysis in Cerebral Infarction (TICI) 2b or greater recanalization with presenting hospital CTPs consistent with “good” (HIR <0.5 and CBVI >0.7) versus “poor” (HIR ≥0.5 and CBVI ≤0.7) indices. Methods: We conducted a retrospective cohort study. A neuroradiologist confirmed the MCA occlusion based on the initial Computerized Tomography Angiogram (CTA). All TICI scores were confirmed by neurointerventionalists blinded to patient outcomes. We defined independent outcome as mRS ≤2, and favorable outcome as an mRS ≤3. We additionally stratified patients as initially presenting to thrombectomy versus non-thrombectomy centers. Results: We identified a total of 162 patients over a 3 ½ year period with an MCA occlusion achieving TICI 2b recanalization or greater, of whom 67 had good indices and 48 had poor indices. For patients with good compared to poor indices, there was a trend for achieving independent outcome (55% vs 37%, p=0.061) that reached significance for favorable outcome (69% vs 50%, p=0.043). Limiting the analysis to only patients presenting to non-thrombectomy centers (n=67), these findings were consistent, with a trend for achieving independent outcome for good versus poor collaterals (48% vs 30% p=0.173), which was again significant for a favorable outcome (66% vs 39%, p=0.036). Across all patients, HIR <0.5 (n=86) or CBVI >0.7 (n=95) were not independently associated with independent outcomes, but for patients presenting to non-thrombectomy centers, an HIR <0.5 alone (n=51) was significantly associated with favorable outcome. Conclusion: For MCA occlusion patients achieving TICI 2b recanalization, the combination of good HIR and CBVI is significantly associated with a favorable functional outcome. For patients presenting to non-thrombectomy centers, HIR alone may be sufficient to predict favorable outcome.

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