Prospective Comparison of Cirrus and Stratus Optical Coherence Tomography for Quantifying Retinal Thickness

Background: We performed exploratory analyses of retinal thickness data from a clinical trial of the AβPP cleaving enzyme (BACE) inhibitor verubecestat in patients with Alzheimer’s disease (AD). Objective: To evaluate: 1) possible retinal thickness changes following BACE inhibition; and 2) possible association between retinal thickness and brain atrophy. Methods: Retinal thickness was measured using spectral-domain optical coherence tomography in a 78-week randomized placebo-controlled trial of verubecestat in 1,785 patients with mild-to-moderate AD. Changes from baseline in retinal pigment epithelium, macular grid retinal nerve fiber layer, central subfield retinal thickness, and macular grid volume were evaluated for verubecestat versus placebo. Correlation analyses were performed to investigate the potential association between macular grid retinal nerve fiber layer and central subfield retinal thickness with brain volumetric magnetic resonance imaging (vMRI) data at baseline, as well as correlations for changes from baseline at Week 78 in patients receiving placebo. Results: Verubecestat did not significantly alter retinal thickness during the trial compared with placebo. At baseline, mean macular grid retinal nerve fiber layer and central subfield retinal thickness were weakly but significantly correlated (Pearson’s r values≤0.23, p-values < 0.01) with vMRI of several brain regions including whole brain, hippocampus, and thalamus. At Week 78, correlations between retinal thickness and brain vMRI changes from baseline in the placebo group were small and mostly not statistically significant. Conclusion: BACE inhibition by verubecestat was not associated with adverse effects on retinal thickness in patients with mild-to-moderate AD. Correlations between retinal thickness and brain volume were observed at baseline. Trial registration: Clinicaltrials.gov NCT01739348 (registered December 3, 2012; https://clinicaltrials.gov/ct2/show/NCT01739348).

Download Full-text

24-Hour variation of optical coherence tomography–measured retinal thickness in diabetic macular edema

European Journal of Ophthalmology ◽

10.5301/ejo.5000119 ◽

2012 ◽

Vol 22 (5) ◽

pp. 785-791 ◽

Cited By ~ 7

Author(s):

Sokratis T. Kotsidis ◽

Simeon S. Lake ◽

Alexandros D. Alexandridis ◽

Nikolaos G. Ziakas ◽

Panagiotis K. Ekonomidis

Keyword(s):

Optical Coherence Tomography ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Retinal Thickness ◽

Optical Coherence

Download Full-text

Quality and Reproducibility of Retinal Thickness Measurements in Two Spectral-Domain Optical Coherence Tomography Machines

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.10-6612 ◽

2011 ◽

Vol 52 (9) ◽

pp. 6925 ◽

Cited By ~ 26

Author(s):

Ilse Krebs ◽

Eva Smretschnig ◽

Sarah Moussa ◽

Werner Brannath ◽

Irene Womastek ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinal Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Thickness Measurements

Download Full-text

Optical Coherence Tomography: An Adjunctive Tool for Differentiating between Choroidal Melanoma and Metastasis

Journal of Ophthalmology ◽

10.1155/2016/9803547 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Vicktoria Vishnevskia-Dai ◽

Dinah Zur ◽

Shiran Yaacobi ◽

Iris Moroz ◽

Hadas Newman ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinal Thickness ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Choroidal Melanoma ◽

Case Series ◽

Subretinal Fluid ◽

Optical Coherence ◽

Choroidal Melanomas ◽

Anterior Choroidal

Purpose.To investigate the value of optical coherence tomography (OCT) for differentiation between choroidal melanoma and metastasis based on characteristics of the anterior choroidal surface and the chorioretinal interface.Methods.This retrospective observational case series included 29 patients with untreated choroidal melanomas and 21 patients with untreated choroidal metastases. Regularity and lobularity characteristics of the anterior choroidal surface were evaluated in a masked manner. Retinal and retinal pigment epithelium (RPE) findings were documented as well.Results.OCT demonstrated a regular and smooth anterior choroidal surface in 89.7% of the eyes with melanoma and in 47.6% of the eyes with metastasis (p=0.002; sensitivity = 89.7%; specificity = 52.4%). The anterior choroidal contour was lobulated in 81.0% of the eyes with metastasis versus 17.2% of the eyes with melanoma (p<0.001; sensitivity = 82.8%; specificity = 81.0%). RPE thickness and neuroretinal characteristics (e.g., retinal thickness, the presence of cysts, and the presence of subretinal fluid) were similar in both choroidal tumors.Conclusion. OCT may serve as a noninvasive adjunctive tool for the differential diagnosis of choroidal tumors. Choroidal melanomas usually demonstrate regular surfaces on OCT, while choroidal metastases usually have an irregular and lobulated surface.

Download Full-text

REPEATABILITY AND REPRODUCIBILITY OF RETINAL THICKNESS MEASUREMENTS WITH SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY USING DIFFERENT SCAN PARAMETERS

Retina ◽

10.1097/iae.0b013e31822f5660 ◽

2012 ◽

Vol 32 (5) ◽

pp. 1007-1012 ◽

Cited By ~ 5

Author(s):

Andrea Giani ◽

Antonio Peroglio Deiro ◽

Giovanni Staurenghi

Keyword(s):

Optical Coherence Tomography ◽

Retinal Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Repeatability And Reproducibility ◽

Thickness Measurements

Download Full-text

Optical Coherence Tomography and Retinal Thickness Assessment for Diagnosis and Management

Retina ◽

10.1016/b978-0-323-02598-0.50093-8 ◽

2006 ◽

pp. 1533-1556 ◽

Cited By ~ 1

Author(s):

Andrew A. Moshfeghi ◽

Elias C. Mavrofrides ◽

Carmen A. Puliafito

Keyword(s):

Optical Coherence Tomography ◽

Retinal Thickness ◽

Optical Coherence ◽

Diagnosis And Management

Download Full-text

Optical Coherence Tomography Characteristics of the Choroid Underlying Congenital Hypertrophy of the Retinal Pigment Epithelium

Ocular Oncology and Pathology ◽

10.1159/000504712 ◽

2020 ◽

Vol 6 (4) ◽

pp. 238-243

Author(s):

Jasmine H. Francis ◽

Ethan K. Sobol ◽

Molly Greenberg ◽

Robert Folberg ◽

David H. Abramson

Keyword(s):

Optical Coherence Tomography ◽

Retinal Pigment Epithelium ◽

Choroidal Thickness ◽

Retinal Thickness ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Enhanced Depth Imaging ◽

Optical Coherence ◽

Depth Imaging ◽

Congenital Hypertrophy

Purpose: This study evaluates and characterizes the choroid underlying congenital hypertrophy of the retinal pigment epithelium (CHRPE). Methods: Retrospective observational study of CHRPE at least 2 mm in diameter. Choroidal vascular architecture was qualitatively examined. Choroidal thickness was measured by 2 independent observers using enhanced depth imaging spectral domain optical coherence tomography. Results: Forty-six eyes of 46 patients with CHRPE were included. Thirty-two lesions had imaging sufficient for analysis. Haller’s layer was healthy in 18 (56%), thin in 13 (41%), and absent in 1 (2%). Sattler’s layer was atrophic in 30 (94%), and choriocapillaris was atrophic in 31 (97%). CHRPE with thinned Haller’s layer had significantly larger diameter. The mean sub-CHRPE choroidal thickness was 82.4 ± 7.9 µm, compared to a thickness of 148.4 ± 9.6 µm in the normal adjacent choroid (p < 0.0001). Mean retinal thickness overlying the CHRPE was 77.3 ± 4.3 µm, compared to a retinal thickness of 137.8 ± 2.9 µm overlying the normal adjacent choroid (p < 0.0001). Sub-CHRPE choroidal thickness was a mean of 56.2 ± 3.1% of the adjacent normal choroidal thickness. Conclusion: The underlying choroid CHRPE is thinner than the adjacent normal choroid. All layers of the choroid can be thin with a preference of the inner Sattler’s and choriocapillaris layers.

Download Full-text