scholarly journals An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis

2018 ◽  
Vol 67 (2) ◽  
pp. 201-208 ◽  
Author(s):  
Syuji Yonekura ◽  
Yoshitaka Okamoto ◽  
Daiju Sakurai ◽  
Kimihiro Okubo ◽  
Minoru Gotoh ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Sublingual Immunotherapy ◽  
Japanese Cedar ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen

In vitro and in vivo inhibitory effects of TLR4 agonist, glucopyranosyl lipid A (GLA), on allergic rhinitis caused by Japanese cedar pollen

Allergy ◽  
2019 ◽  
Vol 75 (2) ◽  
pp. 446-449 ◽  
Author(s):  
Koji Matsumoto ◽  
Hideaki Kouzaki ◽  
Sayuri Yamamoto ◽  
Hirotaka Kikuoka ◽  
Ichiro Tojima ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Lipid A ◽  
Japanese Cedar ◽  
Inhibitory Effects ◽  
Tlr4 Agonist ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen

scholarly journals Safety profile and immunological response of dual sublingual immunotherapy with house dust mite tablet and Japanese cedar pollen tablet

2020 ◽  
Vol 69 (1) ◽  
pp. 104-110 ◽  
Author(s):  
Minoru Gotoh ◽  
Kimihiro Okubo ◽  
Atsushi Yuta ◽  
Yukiko Ogawa ◽  
Hitoshi Nagakura ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Safety Profile ◽  
Sublingual Immunotherapy ◽  
Immunological Response ◽  
Japanese Cedar ◽  
Dust Mite ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen

scholarly journals Absence of Nasal Blockage in a Japanese Cedar Pollen-Induced Allergic Rhinitis Model Mouse

2009 ◽  
Vol 58 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Hiromi Ogita-Nakanishi ◽  
Takeshi Nabe ◽  
Nobuaki Mizutani ◽  
Masanori Fujii ◽  
Shigekatsu Kohno
Keyword(s):  
Allergic Rhinitis ◽  
Japanese Cedar ◽  
Nasal Blockage ◽  
Model Mouse ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen

scholarly journals Immunological parameters in prophylactic sublingual immunotherapy in asymptomatic subjects sensitized to Japanese cedar pollen

2015 ◽  
Vol 64 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Kei-ichi Yamanaka ◽  
Said Ahmad Shah ◽  
Hiroshi Sakaida ◽  
Akisa Yamagiwa ◽  
Sawako Masuda ◽  
...  
Keyword(s):  
Sublingual Immunotherapy ◽  
Japanese Cedar ◽  
Immunological Parameters ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen ◽  
Asymptomatic Subjects

scholarly journals Changes of Micro-RNAs in Asymptomatic Subjects Sensitized to Japanese Cedar Pollen after Prophylactic Sublingual Immunotherapy

2015 ◽  
Vol 6 (1) ◽  
pp. ar.2015.6.0107 ◽  
Author(s):  
Bo Hou ◽  
Mariko Murata ◽  
Ahmad Shah Said ◽  
Hiroshi Sakaida ◽  
Sawako Masuda ◽  
...  
Keyword(s):  
Placebo Group ◽  
Pollen Season ◽  
Sublingual Immunotherapy ◽  
Quantitative Polymerase Chain Reaction ◽  
Japanese Cedar ◽  
Pollen Extract ◽  
Micro Rnas ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen ◽  
Asymptomatic Subjects

Japanese cedar pollinosis is the predominant seasonal allergic rhinitis in Japan, and it has increased in prevalence during the past 10 years. Sublingual immunotherapy (SLIT) is considered a safe and effective treatment for pollinosis. Micro-RNAs (miRNAs) are a class of short single-stranded RNA molecules that posttranscriptionally silence gene expression and may mediate allergic immune responses. The aim of this study was to investigate the miRNA alteration in asymptomatic subjects sensitized to Japanese cedar pollen under prophylactic SLIT under part of a randomized, double-blind, placebo-controlled, multiple-center trial. Analysis was undertaken in 15 asymptomatic subjects sensitized to Japanese cedar pollen–specific IgE (ImmunoCAP class ≥2) who participated in 2013. The SLIT group (n = 6) received standardized Japanese cedar pollen extract and the placebo group (n = 9) received an inactive placebo for 5 months covering the cedar pollen season. Changes in serum miRNAs were measured by real-time quantitative polymerase chain reaction to determine whether SLIT had effects on profiles of circulating miRNA. Seven subjects in the placebo group developed pollinosis symptoms, whereas no subjects in the SLIT group did (p = 0.007). Serum hsa-miR-223 was significantly up-regulated in postseason compared with preseason samples. The hsa-let-7b was significantly more down-regulated in postseason than in preseason samples from the placebo group; however, no significant differences were observed in those from the SLIT group. A significant decrease in circulating let-7b was also observed in the subjects who developed symptoms. Prophylactic SLIT was effective in preventing the development of pollinosis. Alterations in miRNA expression occurred in asymptomatic, sensitized subjects during cedar pollen season.

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