Immunogenicity of Hepatitis B Vaccine in Preterm or Low Birth Weight Infants: A Meta-Analysis

Objective The U.S. Advisory Committee on Immunization Practices (ACIP) recommends that infants born weighing less than 2,000 g receive the hepatitis B (HepB) vaccine at hospital discharge or 30 days of age. This study aimed to assess timely HepB vaccination among low birth weight infants. We hypothesized that many of these vulnerable infants would fail to receive their HepB birth dose on time. Study Design This retrospective cohort study included Washington State infants born weighing less than 2,000 g at an academic medical center between 2008 and 2013. Data were abstracted from electronic health records and linked to vaccine data from the Washington State Immunization Information System. Multivariable logistic regression was used to examine the associations between sociodemographic, clinical, and visit characteristics and HepB vaccination by birth hospitalization discharge or 30 days of age. Results Among 976 study infants, 58.4% received their HepB vaccine by birth hospitalization discharge or 30 days of age. Infants had higher odds of timely HepB vaccination if they were Hispanic (adjusted odds ratio [AOR] = 1.80, 95% confidence interval [CI]: 1.10–2.95) or non-Hispanic black (AOR = 2.28, 95% CI: 1.36–3.80) versus non-Hispanic white or if they were hospitalized 14 days or longer versus less than 14 days (AOR = 2.43, 95% CI: 1.66–3.54). Infants had lower odds of timely HepB vaccination if they were born before 34 weeks versus on or after 34 weeks of gestational age (AOR = 0.41, 95% CI: 0.27–0.63) or if they had an estimated household income less than $50,845 versus 50,845 or greater (AOR = 0.64, 95% CI: 0.48–0.86). Conclusion Many infants born weighing less than 2,000 g did not receive their first HepB birth dose according to ACIP recommendations. Strategies are needed to improve timely HepB vaccination in this high-risk population. Key Points

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Very Low Birth Weight Outcomes

PEDIATRICS ◽

10.1542/peds.89.2.357a ◽

1992 ◽

Vol 89 (2) ◽

pp. 357-357

Author(s):

HELEN HARRISON

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Neonatal Intensive Care ◽

Very Low Birth Weight ◽

Meta Analysis ◽

Low Birth Weight Infants ◽

Randomized Controlled Clinical Trials ◽

Weight Outcomes ◽

Term Evaluation

To the Editor.— The authors of the National Institute of Child Health and Human Development report on neonatal care1 found "important" variations among neonatal intensive care units in philosophies of treatment, methods of treatment, and short-term outcomes. In a recent meta-analysis of follow-up studies,2 researchers document a similarly haphazard approach to the long-term evaluation of very low birth weight survivors. Until randomized controlled clinical trials validate the safety and efficacy of neonatal therapies, and until long-term outcomes are assessed accurately, the treatment of very low birth weight infants should be declared experimental.

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Probiotics Reduce Mortality and Morbidity in Preterm, Low-Birth-Weight Infants: A Systematic Review and Network Meta-analysis of Randomized Trials

Gastroenterology ◽

10.1053/j.gastro.2020.05.096 ◽

2020 ◽

Vol 159 (2) ◽

pp. 467-480 ◽

Cited By ~ 7

Author(s):

Rebecca L. Morgan ◽

Geoffrey A. Preidis ◽

Purna C. Kashyap ◽

Adam V. Weizman ◽

Behnam Sadeghirad ◽

...

Keyword(s):

Systematic Review ◽

Birth Weight ◽

Low Birth Weight ◽

Randomized Trials ◽

Meta Analysis ◽

Low Birth Weight Infants ◽

Mortality And Morbidity

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Is Donated Breast Milk Better Than Formula for Feeding Very Low Birth Weight Infants? A Systematic Review and Meta‐Analysis

Worldviews on Evidence-Based Nursing ◽

10.1111/wvn.12410 ◽

2019 ◽

Vol 16 (6) ◽

pp. 485-494 ◽

Cited By ~ 1

Author(s):

Fei Yu ◽

Bo Cao ◽

Zunjia Wen ◽

Meng Li ◽

Hongbin Chen ◽

...

Keyword(s):

Systematic Review ◽

Birth Weight ◽

Breast Milk ◽

Low Birth Weight ◽

Very Low Birth Weight ◽

Meta Analysis ◽

Low Birth Weight Infants ◽

Better Than

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Insights Image for “Effect of prebiotic and probiotic supplementation on neurodevelopment in preterm very low birth weight infants: findings from a meta-analysis”

Pediatric Research ◽

10.1038/s41390-019-0616-0 ◽

2019 ◽

Vol 87 (5) ◽

pp. 969-969

Author(s):

Ravi Prakash Upadhyay ◽

Sunita Taneja ◽

Ranadip Chowdhury ◽

Tor A. Strand ◽

Nita Bhandari

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Very Low Birth Weight ◽

Meta Analysis ◽

Low Birth Weight Infants ◽

Probiotic Supplementation

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A Systematic Review and Meta-analysis on the Prevalence of Low Birth Weight Infants in Iran

Journal of Pregnancy ◽

10.1155/2020/3686471 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7

Author(s):

Maryam Sabbaghchi ◽

Rostam Jalali ◽

Masoud Mohammadi

Keyword(s):

Systematic Review ◽

Birth Weight ◽

Low Birth Weight ◽

Meta Analysis ◽

Knowledge Network ◽

Low Birth Weight Infants ◽

Policy Makers ◽

Total Prevalence ◽

High Prevalence ◽

The Difference

Background. Low birth weight is a significant index for survival, intrauterine growth, and mortality in infants. Thus, this study is aimed at determining the prevalence of low birth weight in Iranian infants through a systematic review and meta-analysis. Methods. This study was performed by meta-analysis from January 2000 to December 2019. The studies relevant to the topic have been obtained through search in databases of Scopus, ScienceDirect, SID, Magiran, Barakat Knowledge Network System, Medline (PubMed), and Google Scholar. Heterogeneity of the studies has been assessed by the I 2 index, and data analysis was done using Comprehensive Meta-Analysis software. Results. By investigating 14 articles and 93924 infants, the total prevalence of low birth weight in infants in Iran was achieved at 8.5% (95% CI: 7.3-9.9%) according to the meta-analysis; the most prevalence of low birth weight was in infants in Hamedan at 19.1% (95% CI: 21.2-17.2%) in 2007, and the lowest prevalence of low birth weight was in infants in Tonekabon at 4.2% (95% CI: 3.4-5.2%) in 2005, and also, by increasing the sample size, the prevalence of low birth weight increases, by which the difference is statistically significant ( P < 0.05 ). Conclusion. Due to the high prevalence of low birth weight in infants in Iran, health policy-makers must take effective attempts in order to reduce it in infants.

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