Surface-enhanced laser desorption ionization/time-of-flight (SELDI-TOF) mass spectrometry (MS) as a phenotypic method for rapid identification of antibiotic resistance

Anaerobe ◽  
2011 ◽  
Vol 17 (6) ◽  
pp. 444-447 ◽  
Author(s):  
Lenka Dubska ◽  
Katerina Pilatova ◽  
Monika Dolejska ◽  
Zbynek Bortlicek ◽  
Tereza Frostova ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Antibiotic Resistance ◽  
Time Of Flight ◽  
Laser Desorption ◽  
Rapid Identification ◽  
Laser Desorption Ionization ◽  
Ionization Time ◽  
Desorption Ionization ◽  
Surface Enhanced ◽  
Phenotypic Method

scholarly journals Applications of Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) Mass Spectrometry in Defining Salivary Proteomic Profiles

2009 ◽  
Vol 3 (1) ◽  
pp. 74-79 ◽  
Author(s):  
Sandra K Al-Tarawneh ◽  
Sompop Bencharit
Keyword(s):  
Mass Spectrometry ◽  
Proteomic Analysis ◽  
Time Of Flight ◽  
Laser Desorption ◽  
Human Saliva ◽  
Laser Desorption Ionization ◽  
Ionization Time ◽  
Desorption Ionization ◽  
Protein Chips ◽  
Surface Enhanced

Recent advancement in mass spectrometry leads us to a new era of proteomic analysis. Human saliva can be easily collected; however, the complexity of the salivary proteome in the past prevented the use of saliva for proteomic analysis. Here we review the development of proteomic analyses for human saliva and focus on the use of a new mass spectrometric technology known as surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF). SELDI-TOF, a modification of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF), combines the precision of mass spectrometry and the high-through-put nature of protein arrays known as Protein Chips. This technology shows a promising future for salivary proteomic analysis in monitoring treatments and diseases, as well as novel biomarker discovery.

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